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公开(公告)号：EP1452191A3
公开(公告)日：2004-09-22
申请号：EP04076136.3
申请日：2000-06-30
申请人： ETHICON, INC.
发明人： Vyakarnam, Murty N. , Zimmerman, Mark C. , Scopelianos, Angelo George , Roller, Mark B. , Gorky, David V.
CPC分类号： A61L27/3852 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/3817 , A61L27/3843 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10T428/24132 , Y10T428/24149 , Y10T428/24165 , Y10T428/24322 , Y10T428/24793 , Y10T428/249953 , Y10T428/249955 , Y10T428/249958 , Y10T428/249986 , Y10T428/268 , Y10T428/31786 , C08L67/04
摘要： The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了具有通过一个或多个方向的组成和/或微结构梯度的三维相互连接的开孔多孔泡沫。 这些泡沫可以由可吸收和生物相容性聚合物的混合物制成，所述聚合物形成泡沫，其组成梯度从主要由一种聚合物材料转变为主要为第二种聚合物材料。 这些梯度泡沫特别适合于组织工程应用，并且可以设计成模拟组织转变或界面区域。
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公开(公告)号：EP1270018A1
公开(公告)日：2003-01-02
申请号：EP02254563.6
申请日：2002-06-28
申请人： ETHICON, INC.
IPC分类号： A61L2/14 , A61L2/18 , A61L2/20 , A61L27/28 , A61L29/08 , A61L31/08 , A61L33/00 , A61M25/00 , B05D7/24
CPC分类号： A61L27/34 , A61L2/14 , A61L29/085 , A61L31/10 , A61M25/0009 , A61M25/0045
摘要： The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.
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公开(公告)号：EP1234587A1
公开(公告)日：2002-08-28
申请号：EP01301703.3
申请日：2001-02-26
申请人： ETHICON, INC.
发明人： Vyakarnam, Murty N. , Zimmerman, Mark C. , Scopelianos, Angelo George , Melican, Mora C. , Bazilio, Clairene A. , Roller, Mark B. , Gorky, David V. , Chun, Iksoo
CPC分类号： A61L31/146 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/2817 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30064 , A61F2002/30199 , A61F2002/302 , A61F2002/30205 , A61F2002/3021 , A61F2002/30217 , A61F2002/30235 , A61F2002/30242 , A61F2002/30247 , A61F2002/3025 , A61F2002/30253 , A61F2002/30261 , A61F2002/30271 , A61F2002/30273 , A61F2002/30278 , A61F2002/3028 , A61F2002/30283 , A61F2002/30677 , A61F2002/30762 , A61F2002/30784 , A61F2002/3092 , A61F2002/30971 , A61F2002/4648 , A61F2210/0004 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0071 , A61F2230/0076 , A61F2230/0082 , A61F2230/0086 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , C08L67/04
摘要： The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了由连接到通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫的第一纤维层制成的生物相容性复合材料。 这些复合材料可以由可吸收和生物相容的聚合物的混合物制成。 这些生物相容性复合材料特别适用于组织工程应用，可以设计成模拟组织转移或界面区域。
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4.发明授权
公开(公告)号：EP0711548B1
公开(公告)日：1998-01-28
申请号：EP95307368.1
申请日：1995-10-17
申请人： ETHICON INC.
发明人： Scopelianos, Angelo G. , Arnold, Steven C. , Bezwada, Rao S. , Roller, Mark B. , Huxel, Shawn T.
CPC分类号： A61K9/0024 , A61K47/34 , A61L27/18 , C08L67/04
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公开(公告)号：EP1192957B2
公开(公告)日：2016-06-01
申请号：EP01308349.8
申请日：2001-09-28
申请人： ETHICON, INC.
CPC分类号： A61F2/91 , A61B17/00491 , A61B17/0469 , A61B17/0644 , A61B17/11 , A61B17/115 , A61B17/54 , A61B2017/06028 , A61F2/064 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/18 , Y10T428/3154 , A61K2300/00 , C08L27/16 , C08L27/12 , C08L27/14
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公开(公告)号：EP1234587B1
公开(公告)日：2005-11-23
申请号：EP01301703.3
申请日：2001-02-26
申请人： ETHICON, INC.
发明人： Vyakarnam, Murty N. , Zimmerman, Mark C. , Scopelianos, Angelo George , Melican, Mora C. , Bazilio, Clairene A. , Roller, Mark B. , Gorky, David V. , Chun, Iksoo
CPC分类号： A61L31/146 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/2817 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30064 , A61F2002/30199 , A61F2002/302 , A61F2002/30205 , A61F2002/3021 , A61F2002/30217 , A61F2002/30235 , A61F2002/30242 , A61F2002/30247 , A61F2002/3025 , A61F2002/30253 , A61F2002/30261 , A61F2002/30271 , A61F2002/30273 , A61F2002/30278 , A61F2002/3028 , A61F2002/30283 , A61F2002/30677 , A61F2002/30762 , A61F2002/30784 , A61F2002/3092 , A61F2002/30971 , A61F2002/4648 , A61F2210/0004 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0071 , A61F2230/0076 , A61F2230/0082 , A61F2230/0086 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , C08L67/04
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公开(公告)号：EP1270018B1
公开(公告)日：2005-04-13
申请号：EP02254563.6
申请日：2002-06-28
申请人： ETHICON, INC.
IPC分类号： A61L2/14 , A61L2/18 , A61L2/20 , A61L27/28 , A61L29/08 , A61L31/08 , A61L33/00 , A61M25/00 , B05D7/24
CPC分类号： A61L27/34 , A61L2/14 , A61L29/085 , A61L31/10 , A61M25/0009 , A61M25/0045
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8.发明公开Bioabsorbable coatings of surgical devices 有权Bioabsorbierbare Beschichtungenfürchirurgische Artikel
公开(公告)号：EP1321154A2
公开(公告)日：2003-06-25
申请号：EP02258785.1
申请日：2002-12-19
申请人： ETHICON, INC.
CPC分类号： A61L31/10 , A61B17/80 , A61B17/866 , A61B2017/00004 , A61F2/0811 , A61F2002/0858 , A61F2210/0004 , A61L27/34 , A61L27/38 , A61L27/48 , A61L27/52 , A61L27/56 , A61L27/58 , A61L31/14 , A61L2400/10 , C08L5/04 , C08L89/06 , C08L67/04
摘要： Bioabsorbable coatings for bioabsorbable implantable medical devices having dragging or engagement surfaces. The coatings on a surface of the devices reduce device drag.
摘要翻译： 用于具有拖曳或接合表面的生物可吸收可植入医疗装置的生物可吸收涂层。 器件表面上的涂层减少了器件阻力。
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公开(公告)号：EP2848265A2
公开(公告)日：2015-03-18
申请号：EP14197047.5
申请日：2001-09-28
申请人： Ethicon, Inc.
CPC分类号： A61F2/91 , A61B17/00491 , A61B17/0469 , A61B17/0644 , A61B17/11 , A61B17/115 , A61B17/54 , A61B2017/06028 , A61F2/064 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/18 , Y10T428/3154 , A61K2300/00 , C08L27/16 , C08L27/12 , C08L27/14
摘要： An implantable stent made of a biocompatible metal having formed on it
a biocompatible film effective to provide an inert surface to be in contact with body tissue of a mammal upon implantation of said device in said mammal, said film comprising a polyfluoro copolymer, which copolymer:
is prepared from 50 to 85 weight percent of vinylidenefluoride and from 50 to 15 weight percent of hexafluoropropylene, based on the total monomer weight used to prepare said copolymer, and
contains from 9 weight percent hexafluoropropylene, based on the total weight of the copolymer
wherein:
said hexafluoropropylene is capable of providing elastomeric properties to the polyfluoro copolymer; and
said film further comprises a therapeutic and/or pharmaceutical agent mixed with said polyfluoro copolymer.摘要翻译： 一种由生物相容性金属制成的可植入支架，其上形成有生物相容性膜，所述生物相容性膜在植入所述哺乳动物时能有效地提供惰性表面与哺乳动物的身体组织接触，所述膜包含多氟共聚物，该共聚物： 基于用于制备所述共聚物的总单体重量，由50至85重量％的偏二氟乙烯和50至15重量％的六氟丙烯制备，并且含有91至60.6重量％的偏二氟乙烯和39.4重量％至> 9重量％ 六氟丙烯，基于共聚物的总重量，其中：所述六氟丙烯能够为聚氟共聚物提供弹性体性质; 并且所述膜还包含与所述多氟共聚物混合的治疗剂和/或药剂。
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公开(公告)号：EP1764120A1
公开(公告)日：2007-03-21
申请号：EP06077258.9
申请日：2001-09-28
申请人： ETHICON, INC.
CPC分类号： A61F2/91 , A61B17/00491 , A61B17/0469 , A61B17/0644 , A61B17/11 , A61B17/115 , A61B17/54 , A61B2017/06028 , A61F2/064 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/18 , Y10T428/3154 , A61K2300/00 , C08L27/16 , C08L27/12 , C08L27/14
摘要： The present invention includes biocompatible coatings and films for use on implantable medical devices and medical devices containing such coatings and films applied to a surface thereof, which coatings/films are present on the device in an amount effective to provide an inert surface to be in contact with body tissue of a mammal upon implantation of the device in the mammal, and contain a film-forming polyfluoro copolymer prepared from an amount of a monomer selected from the group consisting of vinylidenefluoride and tetrafluoroethylene, and an amount of a second monomer other than the first monomer, wherein the amounts of the first and second monomers are effective to provide the coating and films with properties effective for use in coating implantable medical devices when the coated device is subjected to a maximum temperature of less than about 100°C.
摘要翻译： 本发明包括用于可植入医疗装置的生物相容性涂层和膜，以及包含施加到其表面上的这种涂层和膜的医疗装置，该涂层/薄膜以有效提供惰性表面接触的量存在于该装置上 与植入该哺乳动物的哺乳动物的身体组织，并且含有由一量的选自偏氟乙烯和四氟乙烯的单体制备的成膜多氟共聚物，以及除第 第一单体，其中当涂覆的装置经受小于约100℃的最高温度时，第一和第二单体的量有效地提供具有有效用于涂覆可植入医疗装置的涂层和膜。
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