公开(公告)号：EP1648878B1

公开(公告)日：2009-05-06

申请号：EP04779120.7

申请日：2004-07-23

申请人： EURO-CELTIQUE S.A.

发明人： SUN, Qun ,  WEN, Kate ,  ZHOU, Xiaoming

IPC分类号： C07D401/04 ,  C07D417/14 ,  A61K31/4545 ,  A61P29/00

CPC分类号： C07D417/14 ,  C07D401/04

摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar1, Ar2, X, R3, R4, and m are as disclosed herein.

公开(公告)号：EP2067776A1

公开(公告)日：2009-06-10

申请号：EP09156594.5

申请日：2004-07-23

申请人： EURO-CELTIQUE S.A.

发明人： SUN, Qun ,  ZHOU, Xiaoming ,  WEN, Kate

IPC分类号： C07D401/04 ,  C07D417/14 ,  A61K31/4545 ,  A61P29/00

CPC分类号： C07D417/14 ,  C07D401/04

摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In embodiment, the Piperidine Compound has the formula:

and pharmaceutically acceptable salts thereof, wherein Ar 1 , Ar 2 , X, R 3 , R 4 , and m are as disclosed herein.

摘要翻译： 哌啶化合物; 包含哌啶化合物的组合物; 以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性 脑功能，亨廷顿舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的哌啶化合物。 在实施方案中，哌啶化合物具有下式：及其药学上可接受的盐，其中Ar 1，Ar 2，X，R 3，R 4和m如本文所公开。

公开(公告)号：EP1648878A1

公开(公告)日：2006-04-26

申请号：EP04779120.7

申请日：2004-07-23

申请人： Euro-Celtique S.A.

发明人： SUN, Qun ,  WEN, Kate ,  ZHOU, Xiaoming

IPC分类号： C07D401/04 ,  C07D417/14 ,  A61K31/4545 ,  A61P29/00

CPC分类号： C07D417/14 ,  C07D401/04

摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar1, Ar2, X, R3, R4, and m are as disclosed herein.

公开(公告)号：EP1648878B9

公开(公告)日：2011-03-16

申请号：EP04779120.7

申请日：2004-07-23

申请人： EURO-CELTIQUE S.A.

发明人： SUN, Qun ,  WEN, Kate ,  ZHOU, Xiaoming

IPC分类号： C07D401/04 ,  C07D417/14 ,  A61K31/4545 ,  A61P29/00

CPC分类号： C07D417/14 ,  C07D401/04

摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar1, Ar2, X, R3, R4, and m are as disclosed herein.