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    Piperidine compounds and pharmaceutical compositions containing them
    1.
    发明公开
    Piperidine compounds and pharmaceutical compositions containing them 审中-公开
    Pi ten ten en ten ten ten ten ten ten ten ten ten ten ten ten ten ten ten ten ten

    公开(公告)号：EP2067776A1

    公开(公告)日：2009-06-10

    申请号：EP09156594.5

    申请日：2004-07-23

    申请人： EURO-CELTIQUE S.A.

    发明人： SUN, Qun ,  ZHOU, Xiaoming ,  WEN, Kate

    IPC分类号： C07D401/04 ,  C07D417/14 ,  A61K31/4545 ,  A61P29/00

    CPC分类号： C07D417/14 ,  C07D401/04

    摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In embodiment, the Piperidine Compound has the formula:

    and pharmaceutically acceptable salts thereof, wherein Ar 1 , Ar 2 , X, R 3 , R 4 , and m are as disclosed herein.

    摘要翻译： 哌啶化合物; 包含哌啶化合物的组合物; 以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性 脑功能，亨廷顿舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的哌啶化合物。 在实施方案中，哌啶化合物具有下式：及其药学上可接受的盐，其中Ar 1，Ar 2，X，R 3，R 4和m如本文所公开。

    BENZOAZOLYLPIPERAZINE DERIVATIVES HAVING VR1-ANTAGONIST ACTIVITY
    3.
    发明授权
    BENZOAZOLYLPIPERAZINE DERIVATIVES HAVING VR1-ANTAGONIST ACTIVITY 有权
    具有VR1拮抗剂活性的苯并唑基哌嗪衍生物

    公开(公告)号：EP1583763B1

    公开(公告)日：2008-03-26

    申请号：EP03814351.7

    申请日：2003-12-22

    申请人： Euro-Celtique S.A.

    发明人： SUN, Qun ,  TAFESSE, Laykea ,  VICTORY, Sam

    IPC分类号： C07D417/12 ,  C07D413/12 ,  C07D403/12 ,  C07D401/12 ,  A61K31/495 ,  A61P29/00 ,  A61P13/00

    CPC分类号： C07D417/12 ,  A61K31/495 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

    摘要： A compound of formula (I) wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson’s disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, retricted brain function, Huntington’s chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of Benzoazolylpiperazine Compound are disclosed.

    摘要翻译： 其中Ar 1，A，R 3，x和m如本文所公开且Ar 2为苯并噻唑基，苯并恶唑基或苯并咪唑基或其药学上可接受的盐（“苯并唑基哌嗪化合物”）的组合物， 苯并唑基哌嗪化合物，以及治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性病症，帕金森病，帕金森病，焦虑症，癫痫症，中风，惊厥，瘙痒症状，精神病，认知障碍，记忆 公开了在动物中施用有效量的苯并唑基哌嗪化合物，包括向有需要的动物给药，包括给予有效量的苯并唑基哌嗪化合物，其中所述化合物包含有效量的苯并咪唑基哌嗪化合物或其药学可接受的盐。

    AMINOALKYL-SUBSTITUTED ARYL COMPOUNDS AND THEIR USE AS SODIUM CHANNEL BLOCKERS
    6.
    发明公开
    AMINOALKYL-SUBSTITUTED ARYL COMPOUNDS AND THEIR USE AS SODIUM CHANNEL BLOCKERS 审中-公开
    氨基烷基取代的芳基化合物及它们作为钠通道调节使用

    公开(公告)号：EP1525194A1

    公开(公告)日：2005-04-27

    申请号：EP03748990.3

    申请日：2003-08-01

    申请人： Euro-Celtique S.A.

    发明人： SUN, Qun ,  KYLE, Donald, J.

    IPC分类号： C07D295/13 ,  A61K31/4453 ,  A61K31/5375

    CPC分类号： C07D295/13

    摘要： This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aminoalkyl-substituted aryl compounds of Formula (I), or a pharmaceutically-acceptable salt or solvate thereof, wherein n, X, Rl, R2 and R3 are defined in the specification. The invention is also directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global or focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of acute or chronic pain, neuropathic pain or surgical pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

    THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN
    8.
    发明授权
    THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 有权
    治疗疼痛的治疗药物

    公开(公告)号：EP1664016B9

    公开(公告)日：2009-07-08

    申请号：EP04784627.4

    申请日：2004-09-21

    申请人： EURO-CELTIQUE S.A.

    发明人： SUN, Qun

    IPC分类号： C07D401/04 ,  C07D417/14 ,  C07D413/14 ,  A61K31/44 ,  A61K31/41 ,  A61K31/495

    CPC分类号： C07D213/80 ,  C07D213/81

    摘要： The present invention discloses a compound of formula: where Ar1, Ar2, X, Z1, Z2, R3, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Pyridylene Compound”); compositions comprising an effective amount of a Pyridylene Compound; and methods for treating or preventing pain or other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Pyridylene Compound.

    摘要翻译： 本发明公开了下式的化合物：其中Ar1，Ar2，X，Z1，Z2，R3和m如本文所公开的，或其药学上可接受的盐（“亚磷酰基化合物”）; 包含有效量的吡啶基化合物的组合物; 以及用于治疗或预防动物疼痛或其他病症的方法，其包括向有需要的动物施用有效量的吡啶基化合物。

    PHENYL-CARBOXAMIDE COMPOUNDS USEFUL FOR TREATING PAIN
    9.
    发明授权
    PHENYL-CARBOXAMIDE COMPOUNDS USEFUL FOR TREATING PAIN 有权
    疼痛SUITABLEPHENYLCARBONSÄUREAMIDVERBINDUNGEN的治疗

    公开(公告)号：EP1664041B1

    公开(公告)日：2008-07-02

    申请号：EP04784626.6

    申请日：2004-09-21

    申请人： EURO-CELTIQUE S.A.

    发明人： SUN, Qun

    IPC分类号： C07D417/04 ,  C07D213/06

    CPC分类号： C07D417/12 ,  C07D213/56

    摘要： The present invention discloses compounds of formula: (I) (II) where Ar1, Ar2, X, R1, R2, R3, m, and n are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Phenylene Compound”); compositions comprising an effective amount of a Phenylene Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Phenylene Compound.