公开(公告)号：EP1556354B1

公开(公告)日：2008-01-23

申请号：EP03762220.6

申请日：2003-06-27

申请人： EURO-CELTIQUE S.A.

发明人： KYLE, Donald, J. ,  SUN, Qun ,  TAFESSE, Laykea ,  ZHANG, Chongwu ,  ZHOU, Xiaoming

IPC分类号： C07D213/74 ,  C07D213/85 ,  C07D239/42 ,  C07D237/20 ,  C07D241/20 ,  C07D285/06 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/501 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D213/74 ,  C07D213/85 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D285/06 ,  C07D333/16

摘要： A compound of formula (I): wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a 'Cyanoiminopiperazine Compound'), cornposition, comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndi-oine, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke. a sc z,are, a prurifc condition, psychosis, a cognitive disorder;`a memory deficit, restricted brain function. R rnfington's chorea., arsiyotrophic lateral sclerosis, dementia, retinopathy, a muscie ,spasm„ a migraine, vomiting, dyskinesia or depression in an animal comprising administek-irgT.b ati animal in need thereof an effective amount of a Cyanoi:irinopiperazine Compound are disclosed.