专利检索 ap:("Ecole Normale Superieure Sciences De Lyon" OR "Centre National de la Recherche Scientifique") AND inv:"RUDKIN, Brian B." 第 1 页

1.

发明公开
POLYPEPTIDES HAVING MODULATORY EFFECTS ON CELLS 审中-公开
标题翻译：具有调节作用的多肽细胞

公开(公告)号：EP2120982A1

公开(公告)日：2009-11-25

申请号：EP07856324.4

申请日：2007-11-30

申请人： Ecole Normale Superieure Sciences De Lyon , Centre National de la Recherche Scientifique

发明人： COLAS, Pierre , DE CHASSEY, Benoît , MIKAELIAN, Ivan Jacques , RUDKIN, Brian B.

IPC分类号： A61K38/00 , C07K7/00

CPC分类号： C12N9/0036 , A61K38/00 , C07K7/08 , C07K2319/00 , C12N9/16

摘要： The present invention relates to peptides and polypeptides having the sequence SAVTFAVCAL or variants thereof, capable of binding to Calcineurin and/or to NS5A-TP2 and to their use in therapy, as well as to nucleic acid sequences and vectors encoding these peptides and polypeptides, and to cells comprising said polypeptides, nucleic acid sequences or vectors. The invention further relates to the use of the peptides, polypeptides or their derivatives to bring about phenotypic changes in mammalian cells, particularly to up-regulate calcineurin activity. The invention finally relates to a method for intracellular identification of substances which bind to calcineurin and which modulate the physiological effects of calcineurin.