公开(公告)号：EP2120982A1

公开(公告)日：2009-11-25

申请号：EP07856324.4

申请日：2007-11-30

申请人： Ecole Normale Superieure Sciences De Lyon ,  Centre National de la Recherche Scientifique

发明人： COLAS, Pierre ,  DE CHASSEY, Benoît ,  MIKAELIAN, Ivan Jacques ,  RUDKIN, Brian B.

IPC分类号： A61K38/00 ,  C07K7/00

CPC分类号： C12N9/0036 ,  A61K38/00 ,  C07K7/08 ,  C07K2319/00 ,  C12N9/16

摘要： The present invention relates to peptides and polypeptides having the sequence SAVTFAVCAL or variants thereof, capable of binding to Calcineurin and/or to NS5A-TP2 and to their use in therapy, as well as to nucleic acid sequences and vectors encoding these peptides and polypeptides, and to cells comprising said polypeptides, nucleic acid sequences or vectors. The invention further relates to the use of the peptides, polypeptides or their derivatives to bring about phenotypic changes in mammalian cells, particularly to up-regulate calcineurin activity. The invention finally relates to a method for intracellular identification of substances which bind to calcineurin and which modulate the physiological effects of calcineurin.

公开(公告)号：EP1729818A2

公开(公告)日：2006-12-13

申请号：EP05746947.0

申请日：2005-03-31

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Ecole Normale Superieure Sciences De Lyon

发明人： HASSERODT, Jens

IPC分类号： A61K49/00

CPC分类号： A61K49/106 ,  A61K49/085 ,  A61K49/10 ,  C07D401/14

摘要： The invention relates to contrast agents for magnetic resonance imaging, comprising a chelating ligand and a transition metal ion, said ligand bearing a substituent that can react chemically or biochemically with a target substance, thereby causing a spin state change.

公开(公告)号：EP1729818B1

公开(公告)日：2009-09-23

申请号：EP05746947.0

申请日：2005-03-31

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Ecole Normale Superieure Sciences De Lyon

发明人： HASSERODT, Jens

IPC分类号： A61K49/00 ,  A61K49/06 ,  A61K49/12

CPC分类号： A61K49/106 ,  A61K49/085 ,  A61K49/10 ,  C07D401/14

摘要： The invention relates to contrast agents for magnetic resonance imaging, comprising a chelating ligand and a transition metal ion, said ligand bearing a substituent that can react chemically or biochemically with a target substance, thereby causing a spin state change.

公开(公告)号：EP1779200A1

公开(公告)日：2007-05-02

申请号：EP05783993.8

申请日：2005-07-01

申请人： Ecole Normale Superieure Sciences De Lyon ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： BOURAYA, Djamel ,  PLACE, Christophe

IPC分类号： G03F7/20 ,  H01L21/00

CPC分类号： G03F7/162 ,  G03F7/3021 ,  G03F7/70991 ,  H01L21/67155

摘要： The invention concerns a device for microstructuring the surface of at least one substrate characterized in that it comprises a support frame (2) including at least means (6) for conveying the substrate (S) comprising preferably means (15) for supporting the substrate adapted to maintain the substrate in or relative to each of the modules so as to avoid any change of support when the substrate is shifted from one module to the other, a module for applying a photosensitive resin layer on the substrate, a module (20) for automatic exposure using a laser beam of the resin layer on the substrate based on a programmed scheme, a so-called developing module for removing the part of the resin layer which has been exposed of the part or the resin layer which has not been exposed, a module for chemically etching the substrate, a module for cleaning the substrate, and a control unit (7).

摘要翻译： 本发明涉及一种用于对至少一个基底的表面进行微结构化的装置，其特征在于其包括至少包括用于输送基底（S）的装置（6）的支撑框架（2），优选地包括用于支撑基底的装置（15） 将衬底保持在或相对于每个模块，以便当衬底从一个模块移动到另一个模块时避免支撑的任何变化，用于在衬底上施加光敏树脂层的模块，用于模块（20）的模块 基于编程方案使用基板上的树脂层的激光束进行自动曝光，所谓的显影模块用于去除已曝光的部分树脂层或未曝光的树脂层， 用于化学蚀刻衬底的模块，用于清洁衬底的模块以及控制单元（7）。