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    NITROGENOUS TRICYCLIC COMPOUNDS AND DRUGS COMPRISING THE SAME
    1.
    发明公开
    NITROGENOUS TRICYCLIC COMPOUNDS AND DRUGS COMPRISING THE SAME 失效
    医疗器械制造商维吾尔自行车

    公开(公告)号：EP0889037A1

    公开(公告)日：1999-01-07

    申请号：EP97907297.2

    申请日：1997-03-13

    申请人： Eisai Co., Ltd.

    发明人： MIYAMOTO, Mitsuaki ,  YOSHIUCHI, Tatsuya ,  SATO, Keizo ,  KAINO, Makoto ,  TANAKA, Masayuki ,  SOEJIMA, Motoharu ,  MORIYA, Katsuhiro ,  SAKUMA, Yoshinori ,  YAMADA, Koji ,  HARADA, Kokichi ,  NISHIZAWA, Yukio ,  KOBAYASHI, Seiichi ,  OKITA, Makoto ,  KATAYAMA, Koichi

    IPC分类号： C07D219/14 ,  C07D243/38 ,  C07D279/24 ,  C07D279/34 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/54 ,  A61K31/645

    CPC分类号： C07D417/06 ,  C07D279/22 ,  C07D279/24 ,  C07D417/12 ,  C09B21/00 ,  C09B57/08

    摘要： To provide a novel phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative efficacious against diseases in which histamine, leukotrienes, etc. participate.
    A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by the following formula are efficacious in preventing or treating diseases in which chemical mediators such as histamine and leukotrienes participate, for example, asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy and food allergy.
    A nitrogen-containing tricyclic compound represented by the following formula (I), a hydrate thereof or a pharmacologically acceptable salt thereof:
       (wherein D represents alkylene, etc.)
    wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are the same or different from each other and each represents hydrogen, hydroxy, cyano, nitro, optionally substituted carbamoyl, halogeno, optionally halogenated lower alkyl, etc.; Z represents -S-, -SO-, -SO 2 -, =NO-substituent, -NC(O)- or =NN-substituent; and Q represents, for example, -NR 20 R 21 (wherein R 20 and R 21 are the same or different from each other and each represents hydrogen, optionally halogenated lower alkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl, or R 20 and R 21 may form together with the nitrogen atom to which they are bonded a 3- to 8-membered ring).

    摘要翻译： 提供对组胺，白三烯等参与的疾病有效的新型吩噻嗪，吖啶酮，吖啶酮肟，吖啶酮腙和二苯并二氮杂衍生物。 由下式表示的吩噻嗪，吖啶酮，吖啶酮肟，吖啶酮腙和二苯并二氮杂衍生物可有效预防或治疗化学介质如组胺和白三烯参与的疾病，例如哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，干草 发烧，胃肠道过敏和食物过敏。 由下式（I）表示的含氮三环化合物，其水合物或其药理学上可接受的盐：（其中D表示亚烷基等，其中R 1，R 2， R 3，R 4，R 5，R 6，R 7和R 8彼此相同或不同，各自表示氢，羟基，氰基，硝基，任选取代的氨基甲酰基， 卤代，任选卤代的低级烷基等; Z表示-S-，-SO-，-SO 2 - ，= NO-取代基，-NC（O） - 或= N - 取代基; Q表示例如-NR R 20和R 21彼此相同或不同，各自表示氢，任选卤代的低级烷基，任选取代的芳基，任选取代的芳烷基，任选取代的杂芳基或任选取代的 杂芳基烷基或R 20和R 21可以与它们所键合的氮原子一起形成3-至8-元环）。