公开(公告)号：EP0609441B1

公开(公告)日：1999-07-21

申请号：EP92920700.9

申请日：1992-09-30

申请人： Eisai Co., Ltd.

发明人： AKASAKA, Kozo ,  KAJIWARA, Akiharu ,  NAGATO, Satoshi ,  IIMURA, Youichi ,  YOSHIDA, Ichirou ,  SASAKI, Atsushi ,  MIZUNO, Masanori ,  KUBOTA, Atsuhiko ,  KAGAYA, Takaki ,  KOMATSU, Mariko

IPC分类号： C07D263/56 ,  C07D417/14 ,  A61K31/42 ,  A61K31/425 ,  C07D417/04

CPC分类号： C07D263/57 ,  C07D417/04 ,  C07D417/14

摘要： An oxazolidone derivative represented by general formula (I) and having a monoamine oxidase inhibitory activity, a pharmacologically acceptable salt thereof, and a drug containing the same as the active ingredient for preventing or treating diseases for which a monoamine oxidase inhibitory activity is efficacious. In formula (I) A and B represent each nitrogen, sulfur or oxygen provided that either A or B represents nitrogen; R1 represents a group of formula (a) wherein n and m represent each an integer of 0, 1 to 4; and R?3 and R4¿ represent each hydrogen, hydroxy, lower alkyl, etc.; a group of formula (b) wherein p and q represent each an integer of 0, 1 to 4; and X represents oxygen, sulfur, etc.; a group of formula (c) wherein R?5 and R6¿ represent each hydrogen, cyanoalkyl, etc., or alternatively R?5 and R6¿ are bonded to each other to represent a ring together with the nitrogen atom to which they are bonded; and so forth; R2 represents hydrogen or lower alkyl; and the bond --- represents either a single or a double bond.

公开(公告)号：EP0609441A1

公开(公告)日：1994-08-10

申请号：EP92920700.9

申请日：1992-09-30

申请人： Eisai Co., Ltd.

发明人： AKASAKA, Kozo ,  KAJIWARA, Akiharu ,  NAGATO, Satoshi ,  IIMURA, Youichi ,  YOSHIDA, Ichirou ,  SASAKI, Atsushi ,  MIZUNO, Masanori ,  KUBOTA, Atsuhiko ,  KAGAYA, Takaki ,  KOMATSU, Mariko

IPC分类号： C07D263/56 ,  C07D417/14 ,  A61K31/42 ,  A61K31/425 ,  C07D417/04

CPC分类号： C07D263/57 ,  C07D417/04 ,  C07D417/14

摘要： An oxazolidone derivative represented by general formula (I) and having a monoamine oxidase inhibitory activity, a pharmacologically acceptable salt thereof, and a drug containing the same as the active ingredient for preventing or treating diseases for which a monoamine oxidase inhibitory activity is efficacious. In formula (I) A and B represent each nitrogen, sulfur or oxygen provided that either A or B represents nitrogen; R¹ represents a group of formula (a) wherein n and m represent each an integer of 0, 1 to 4; and R³ and R⁴ represent each hydrogen, hydroxy, lower alkyl, etc.; a group of formula (b) wherein p and q represent each an integer of 0, 1 to 4; and X represents oxygen, sulfur, etc., a group of formula (c) wherein R⁵ and R⁶ represent each hydrogen, cyanoalkyl, etc., or alternatively R⁵ and R⁶ are bonded to each other to represent a ring together with the nitrogen atom to which they are bonded; and so forth; R² represents hydrogen or lower alkyl; and the bond ---- ¯ represents either a single or a double bond.

摘要翻译： 具有通式（I）表示的具有单胺氧化酶抑制活性的恶唑烷酮衍生物及其药理学上可接受的盐，以及含有与用于预防或治疗单胺氧化酶抑制活性有效的疾病的活性成分相同的药物。 在式（I）中，A和B各自表示氮，硫或氧，只要A或B表示氮; R 1表示式（a）的基团，其中n和m各自表示0,1或4的整数; R 3和R 4各自代表氢，羟基，低级烷基等; 式（b）的基团，其中p和q各自表示0,1或4的整数; X表示氧，硫等，其中R 5和R 6各自代表氢，氰基烷基等，或者R 5和R 6与式（c）的基团键合到 彼此表示与它们所键合的氮原子一起形成的环; 等等; R 2表示氢或低级烷基; 债券----表示单一或双重债券。