公开(公告)号：EP0329785B1

公开(公告)日：1994-11-30

申请号：EP87900286.3

申请日：1986-12-26

申请人： Eisai Co., Ltd.

发明人： MACHIDA, Yoshimasa ,  KAMIYA, Takashi ,  NEGI, Shigeto ,  NAITO, Toshihiko ,  KOMATSU, Yuuki ,  NOMOTO, Seiichiro ,  SUGIYAMA, Isao ,  YAMAUCHI, Hiroshi

IPC分类号： C07D501/24 ,  A61K31/545

CPC分类号： C07D501/24

摘要： Cephalosporin derivatives represented by general formula (I), (wherein R1 represents a lower alkyl group, A represents (II) (wherein R2 and R3 may be the same or different and each represents a lower alkyl group, and R4 represents a substituted lower alkyl group or an amino group), an optionally substituted group represented by formulae (III), (IV), (V) (wherein R5 represents a lower alkyl group) or a group of formula (VI) (wherein R5 is the same as defined above and R6 represents a hydroxy-lower alkyl group or a carboxyl group)) and pharmaceutically acceptable salts thereof, processes for their preparation, and antibacterial agents containing them.

公开(公告)号：EP0329785A1

公开(公告)日：1989-08-30

申请号：EP87900286.3

申请日：1986-12-26

申请人： Eisai Co., Ltd.

发明人： MACHIDA, Yoshimasa ,  KAMIYA, Takashi ,  NEGI, Shigeto ,  NAITO, Toshihiko ,  KOMATSU, Yuuki ,  NOMOTO, Seiichiro ,  SUGIYAMA, Isao ,  YAMAUCHI, Hiroshi

IPC分类号： C07D501/24 ,  A61K31/545

CPC分类号： C07D501/24

摘要： Cephalosporin derivatives represented by general formula (I) [wherein R 1 represents a lower alkyl group, A represents (II) (wherein R 2 and R 3 may be the same or different and each represents a lower alkyl group, and R 4 represents a substituted lower alkyl group or an amino group), an optionally substituted group represented by formulae (III), (IV), (V) (wherein Rs represents a lower alkyl group] or a group of formula (VI) (wherein R 5 is the same as defined above and R 6 represents a hydroxy- lower alkyl group or a carboxyl group)] and pharmaceutically acceptable salts thereof, processes for their preparation, and antibacterial agents containing them.

摘要翻译： 头孢菌素衍生物 式（I）是新的; 其中R1是低级烷基; A是N + R2R3R4; R2和R3是低级烷基; R4是氨基或是低级烷基选择。 substd。 氨基甲酰基，羧基，低级烷基氨基，巯基，低级烷酰基，羟基或肼基羰基; 或A可以是杂环gp。 通过季N（12 gps，特别声明包括（II）和（III）和（IV））选择。 substd。 氨基甲酰基，低级烷基二硫代，低级烷基，氨磺酰基，甲脒基或羧基; R5是低级烷基; 并且R 6是羧基或羟基 - 低级烷基。 A是pref。 （Ⅴ）（Ⅵ）（Ⅶ）或32个其他基团。 7β-（2-（5-氨基-1,2,4-噻二唑-3-基）-Z-2-甲氧基亚氨基乙酰亚胺基）-3-（E-3-（氨基甲酰基甲基咪唑基）-1-丙烯-1-酮 吡啶-3-基）-3-头孢烯-4-羧酸酯和其他8个cpds。 氨基和羧基保护的（I，A =卤素）与叔丁基的反应。 胺，然后脱保护。