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1.发明公开Peptide, a process for producing the heptacosapeptide and the use of the heptacosapeptide for producing secretin 失效肽，制备Heptacosapeptiden和它们用于生产分泌的过程。
公开(公告)号：EP0047997A2
公开(公告)日：1982-03-24
申请号：EP81107186.9
申请日：1981-09-11
申请人： Eisai Co., Ltd.
发明人： Uchiyama, Mikio , Sato, Takashi , Yoshino, Hiroshi , Tsuchiya, Yukata , Konishi, Masayuki , Tsujii, Masahiko , Hisatake, Yoshihiko , Koiwa, Atsushi
IPC分类号： C07C103/52
CPC分类号： C07K5/101 , C07K14/645 , Y02P20/55
摘要： A heptacosapeptide is disclosed having the following structural formula:
Boc-His(Boc)-Ser(Bu t )-Asp(OBu t )-Gly-Thr(Bu t )-Phe-Thr(Bu t )-Ser(Bu t )-Glu(OBu t )-Leu-Ser(Bu t )-Arg(X)-Leu-Arg(X)-AsplOBu t )-Ser(Bu 2 1-Ala-Arg(X)-Leu-Gln-Arg(X)-Leu-Leu-Gln-Gly-Leu-Val-NH2, in which X is a group having the formula:
where R is an alkyl or alkoxy and m is an integer of 1 to 3, provided that R's may be the same or different in case m is 2 or 3. Said heptacosapeptide can be produced by condensation of a novel decapeptide with a heptapeptide which are also disclosed. The heptacosapeptide can be used for production of a secretin.-
公开(公告)号：EP0081831A3
公开(公告)日：1984-08-08
申请号：EP82111494
申请日：1982-12-10
申请人： Eisai Co., Ltd.
IPC分类号： C12N09/66
CPC分类号： C12N9/6448 , Y10S435/814
摘要： A process is disclosed for purifying elastase by precipitating elastase from an aqueous, elastasecontaining solution, in which the electroconductivity of said aqueous solution is adjusted to 3 millimhos per centimeter or less and the pH of the solution is adjusted to a value of from 2 to 5. The electroconductivity of said aqueous solution is preferably adjusted to 3 millimhos per centimeter or less by means of ultrafiltration.
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3.发明公开Peptide, a process for producing the heptacosapeptide and the use of the heptacosapeptide for producing secretin 失效肽，一种生产羟基磷酸酯的方法和用于生产分泌物的羟基磷酸酯
公开(公告)号：EP0047997A3
公开(公告)日：1982-05-19
申请号：EP81107186
申请日：1981-09-11
申请人： Eisai Co., Ltd.
发明人： Uchiyama, Mikio , Sato, Takashi , Yoshino, Hiroshi , Tsuchiya, Yukata , Konishi, Masayuki , Tsujii, Masahiko , Hisatake, Yoshihiko , Koiwa, Atsushi
IPC分类号： C07C103/52
CPC分类号： C07K5/101 , C07K14/645 , Y02P20/55
摘要： A heptacosapeptide is disclosed having the following structural formula: Boc-His(Boc)-Ser(Bu t )-Asp(OBu t )-Gly-Thr(Bu t )-Phe-Thr(Bu t )-Ser(Bu t )-Glu(OBu t )-Leu-Ser(Bu t )-Arg(X)-Leu-Arg(X)-AsplOBu t )-Ser(Bu 2 1-Ala-Arg(X)-Leu-Gln-Arg(X)-Leu-Leu-Gln-Gly-Leu-Val-NH2, in which X is a group having the formula:
where R is an alkyl or alkoxy and m is an integer of 1 to 3, provided that R's may be the same or different in case m is 2 or 3. Said heptacosapeptide can be produced by condensation of a novel decapeptide with a heptapeptide which are also disclosed. The heptacosapeptide can be used for production of a secretin.-
公开(公告)号：EP0087066B1
公开(公告)日：1986-05-28
申请号：EP83101231.5
申请日：1983-02-09
申请人： Eisai Co., Ltd.
发明人： Uchiyama, Mikio , Sato, Takashi , Yoshino, Hiroshi , Tsuchiya, Yutaka , Konishi, Masayuki , Tsujii, Masahiko , Hisatake, Yoshihiko , Koiwa, Atsushi
CPC分类号： C07K14/645
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5.发明授权Peptide, a process for producing the heptacosapeptide and the use of the heptacosapeptide for producing secretin 失效肽类，生产乙酰肝素的方法和用于生产分泌物的肝素肽
公开(公告)号：EP0047997B1
公开(公告)日：1984-05-16
申请号：EP81107186.9
申请日：1981-09-11
申请人： Eisai Co., Ltd.
发明人： Uchiyama, Mikio , Sato, Takashi , Yoshino, Hiroshi , Tsuchiya, Yukata , Konishi, Masayuki , Tsujii, Masahiko , Hisatake, Yoshihiko , Koiwa, Atsushi
IPC分类号： C07C103/52
CPC分类号： C07K5/101 , C07K14/645 , Y02P20/55
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6.发明授权Process for the preparation of allyl quinone derivatives, and intermediates 失效一种用于制备Allylchinon衍生物和中间体的方法
公开(公告)号：EP0670300B1
公开(公告)日：1999-06-23
申请号：EP95102898.4
申请日：1995-03-01
申请人： Eisai Co., Ltd.
发明人： Hamamura, Kimio , Seki, Chiaki , Konishi, Masayuki
IPC分类号： C07C205/37 , C07C201/12
CPC分类号： C07C205/37
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公开(公告)号：EP0081831B1
公开(公告)日：1986-03-26
申请号：EP82111494.9
申请日：1982-12-10
申请人： Eisai Co., Ltd.
IPC分类号： C12N9/66
CPC分类号： C12N9/6448 , Y10S435/814
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公开(公告)号：EP0087066A1
公开(公告)日：1983-08-31
申请号：EP83101231.5
申请日：1983-02-09
申请人： Eisai Co., Ltd.
发明人： Uchiyama, Mikio , Sato, Takashi , Yoshino, Hiroshi , Tsuchiya, Yutaka , Konishi, Masayuki , Tsujii, Masahiko , Hisatake, Yoshihiko , Koiwa, Atsushi
CPC分类号： C07K14/645
摘要： Purified secretin is obtained by subjecting crude secretin to reversed-phase high-performance liquid chromatography using, as an eluant, a solvent mixture of an acid or salt thereof and an organic solvent.
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公开(公告)号：EP0081831A2
公开(公告)日：1983-06-22
申请号：EP82111494.9
申请日：1982-12-10
申请人： Eisai Co., Ltd.
IPC分类号： C12N9/66
CPC分类号： C12N9/6448 , Y10S435/814
摘要： A process is disclosed for purifying elastase by precipitating elastase from an aqueous, elastasecontaining solution, in which the electroconductivity of said aqueous solution is adjusted to 3 millimhos per centimeter or less and the pH of the solution is adjusted to a value of from 2 to 5. The electroconductivity of said aqueous solution is preferably adjusted to 3 millimhos per centimeter or less by means of ultrafiltration.
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