公开(公告)号：EP2241567A1

公开(公告)日：2010-10-20

申请号：EP09710649.6

申请日：2009-02-09

申请人： Eisai R&D Management Co., Ltd.

发明人： OZAKI, Fumihiro ,  SOEJIMA, Motohiro ,  ISHIDA, Tasuku ,  NORIMINE, Yoshihiko ,  KURUSU, Nobuyuki ,  DOI, Eriko ,  KANEKO, Toshihiko ,  HASEGAWA, Daiju ,  KOBAYASHI, Kiyoaki ,  YAMAMOTO, Noboru

IPC分类号： C07D451/06 ,  A61K31/439 ,  A61K31/46 ,  A61K31/4985 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/55 ,  A61P3/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/20 ,  A61P29/02 ,  A61P43/00 ,  C07D451/14 ,  C07D519/00

CPC分类号： C07D451/06 ,  C07D451/02 ,  C07D451/04 ,  C07D519/00

摘要： Compounds represented by formula (I) and pharmaceutically acceptable salts thereof have excellent sodium channel inhibitory action and are useful as therapeutic agents and analgesics for various kinds of neuralgia, neuropathy, epilepsy, insomnia, premature ejaculation and the like.

wherein Q represents ethylene, etc., R 1 , R 2 and R 3 represent hydrogen, etc., X 1 represents C 1-6 alkylene, etc., X 2 represents C 1-6 alkylene, etc., A 1 represents a 5- to 6-membered heterocyclic group, etc., and A 2 represents C 6-14 aryl, etc.

摘要翻译： 由式（I）表示的化合物及其药学上可接受的盐具有优异的钠通道抑制作用，可用作各种神经痛，神经病，癫痫，失眠，早泄等的治疗剂和止痛剂。 其中Q表示乙烯等，R 1，R 2和R 3表示氢等，X 1表示C 1-6亚烷基等，X 2表示C 1-6亚烷基等，A 1表示 5-至6-元杂环基等，A 2表示C 6-14芳基等

公开(公告)号：EP1484327B1

公开(公告)日：2007-08-01

申请号：EP03708607.1

申请日：2003-03-14

申请人： Eisai R&D Management Co., Ltd.

发明人： OZAKI, Fumihiro ,  ONO, Mutsuko ,  KAWANO, Koki ,  NORIMINE, Yoshihiko c/o EISAI Co.,Ltd.Tsukuba Lab. ,  ONOGI, Tatsuhiro ,  YOSHINAGA, Takashi c/o EISAI Co.,Ltd.Tsukuba Lab. ,  KOBAYASHI, Kiyoaki ,  SUZUKI, Hiroyuki ,  MINAMI, Hiroe c/o EISAI Co., Ltd. Tsukuba Lab. ,  SAWADA, Kohei

IPC分类号： C07D401/04 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D451/14 ,  C07D498/10 ,  C07D417/06 ,  C07D498/04 ,  A61K31/444 ,  A61K31/4545 ,  A61P25/28

CPC分类号： C07D401/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5365 ,  A61K31/55 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/06

摘要： A compound represented by the general formula (I), a salt thereof, or a hydrate of either: (I) wherein X1, X2, X3, and X4 each independently means a single bond, C1-6 alkylene, etc.; A2 means optionally substituted phenyl, etc.; A1 means an optionally substituted group represented by -C(=Q1)- [wherein Q1 means oxygen, sulfur, or a group represented by =N-R11 (wherein R11 means hydrogen or C1-6 alkyl)], a 5- to 7-membered nitrogenous heterocyclic group, etc.; and Z1 means piperidinediyl, etc.