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公开(公告)号：EP3057948A1
公开(公告)日：2016-08-24
申请号：EP14790936.0
申请日：2014-10-14
发明人： HAWKINS, Lynn , BOIVIN, Roch , HANSEN, Hans , ISHIZAKA, Sally , MACKEY, Matthew , SCHILLER, Shawn , OGAWA, Chikako , NARAYAN, Sridhar , BERTINATO, Peter , BERGER, Gregory , ENDO, Atsushi , YU, Robert T.
IPC分类号： C07D401/04 , A61K31/4545 , A61P37/00
CPC分类号： C07D401/02 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
摘要翻译： 本公开的实施方案涉及用作Toll样受体7和/或8的拮抗剂或抑制剂的选择性取代的喹啉化合物及其在有效治疗系统性红斑狼疮（SLE）和狼疮性肾炎的药物组合物中的用途。
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公开(公告)号：EP2021003A2
公开(公告)日：2009-02-11
申请号：EP07795237.2
申请日：2007-05-24
发明人： SPYVEE, Mark , SELETSKY, Boris , SCHILLER, Shawn , FANG, Francis
CPC分类号： A61K31/435 , A61K31/55
摘要： The invention relates to compounds of formula I: [INSERT FORMULA I] along with pharmaceutical compositions containing the same and methods of use thereof for the treatment of autoimmune disease.
摘要翻译： 本发明涉及式I化合物：[插入式I]以及含有其的药物组合物及其用于治疗自身免疫性疾病的方法。
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公开(公告)号：EP3995495A1
公开(公告)日：2022-05-11
申请号：EP21193428.6
申请日：2014-10-14
发明人： CARLSON, Eric , HANSEN, Hans , MACKEY, Matthew , SCHILLER, Shawn , OGAWA, Chikako , DAVIS, Heather
IPC分类号： C07D413/14 , C07D413/04
摘要： Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：EP2855476A2
公开(公告)日：2015-04-08
申请号：EP13729184.5
申请日：2013-05-31
发明人： BOIVIN, Roch , CARLSON, Eric , ENDO, Atsushi , HANSEN, Hans , ISHIZAKA, Sally , MACKEY, Matthew , NARAYAN, Sridhar , SATOH, Takashi , SCHILLER, Shawn , HAWKINS, Lynn D.
IPC分类号： C07D471/04 , A61K31/519 , A61P37/00
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
摘要翻译： 本公开的实施方案涉及充当Toll样受体7和/或8的拮抗剂或抑制剂的四氢吡唑并嘧啶化合物，以及它们在有效治疗系统性红斑狼疮（SLE）和狼疮肾炎
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公开(公告)号：EP2855476B1
公开(公告)日：2018-09-05
申请号：EP13729184.5
申请日：2013-05-31
发明人： BOIVIN, Roch , CARLSON, Eric , ENDO, Atsushi , HANSEN, Hans , ISHIZAKA, Sally , MACKEY, Matthew , NARAYAN, Sridhar , SATOH, Takashi , SCHILLER, Shawn , HAWKINS, Lynn D.
IPC分类号： C07D471/04 , A61K31/519 , A61P37/00
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：EP2220087A1
公开(公告)日：2010-08-25
申请号：EP07867469.4
申请日：2007-11-15
发明人： SPYVEE, Mark , SHAFFER, Christina J. , SELETSKY, Boris M. , SCHILLER, Shawn , LIU, Jia , LI, Xiang-Yi Li , CHEN, Qian , BOIVIN, Roch
IPC分类号： C07D471/20
CPC分类号： C07D471/20
摘要： The present invention provides an enantiomerically pure compound of Formula (I) along with pharmaceutical formulations containing the same and methods of use thereof.
摘要翻译： 本发明提供了式（I）的对映体纯的化合物以及含有其的药物制剂及其使用方法。
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公开(公告)号：EP3057948B1
公开(公告)日：2018-03-14
申请号：EP14790936.0
申请日：2014-10-14
发明人： HAWKINS, Lynn , BOIVIN, Roch , HANSEN, Hans , ISHIZAKA, Sally , MACKEY, Matthew , SCHILLER, Shawn , OGAWA, Chikako , NARAYAN, Sridhar , BERGER, Gregory , ENDO, Atsushi , YU, Robert T. ,
IPC分类号： C07D401/02 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/4545 , A61P37/00
CPC分类号： C07D401/02 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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8.发明公开
公开(公告)号：EP3057964A1
公开(公告)日：2016-08-24
申请号：EP14790937.8
申请日：2014-10-14
发明人： HAWKINS, Lynn , CARLSON, Eric , HANSEN, Hans , MACKEY, Matthew , SCHILLER, Shawn , OGAWA, Chikako , DAVIS, Heather , ENDO, Atsushi , ISHIZAKA, Sally
IPC分类号： C07D413/14 , C07D403/14 , C07D413/04 , A61K31/535 , A61K31/47 , A61P37/00
CPC分类号： C07D417/14 , C07B2200/07 , C07D215/48 , C07D401/10 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D493/10 , C12Q1/6897 , G01N33/5023 , G01N33/5047
摘要： Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
摘要翻译： 本公开的实施方案涉及用作Toll样受体7和/或8的拮抗剂或抑制剂的选择性取代的喹啉化合物及其在有效治疗系统性红斑狼疮（SLE）和狼疮肾炎的药物组合物中的用途。
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公开(公告)号：EP2211616A1
公开(公告)日：2010-08-04
申请号：EP08855523.0
申请日：2008-11-26
IPC分类号： A01N43/00
CPC分类号： C07D471/20 , C07D513/04
摘要： A method of making a compound of Formula I: is carried out by (a) providing a compound of Formula (II) or (III): wherein ring A is C3-14 aryl or C3-14 heteroaryl such as phenyl or furanyl, and then (b) combining the compound of Formula (II) or (III) with an acid to produce a compound of Formula I.
摘要翻译： 通过（a）提供式（II）或（III）的化合物进行制备式I化合物的方法：其中环A为C 3-14芳基或C 3-14杂芳基，例如苯基或呋喃基，和 然后（b）将式（II）或（III）的化合物与酸结合以产生式I的化合物。
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公开(公告)号：EP3626717A1
公开(公告)日：2020-03-25
申请号：EP19194302.6
申请日：2014-10-14
发明人： HAWKINS, Lynn , CARLSON, Eric , HANSEN, Hans , MACKEY, Matthew , SCHILLER, Shawn , OGAWA, Chikako , DAVIS, Heather
IPC分类号： C07D413/14 , C07D403/14 , C07D413/04 , A61K31/535 , A61K31/47 , A61P37/00 , C07D215/48 , C07D401/10 , C07D401/14 , C07D417/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D493/10
摘要： Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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