公开(公告)号：EP1992622A1

公开(公告)日：2008-11-19

申请号：EP07714569.6

申请日：2007-02-20

申请人： Eisai R&D Management Co., Ltd.

发明人： MIYAZAKI, Kazuki ,  KUSANO, Kazutomi ,  TAKASE, Yasutaka ,  ASANO, Osamu ,  SHIRATO, Manabu ,  WAKITA, Hisashi ,  ISHII, Naoto ,  SAEKI, Takao

IPC分类号： C07D239/84 ,  A61K31/517 ,  A61P17/00 ,  A61P17/04 ,  A61P37/08

CPC分类号： C07D239/84

摘要： A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like:

wherein R represents hydroxyl, C 1-6 alkoxy optionally substituted with C 1-6 alkoxy, or amino optionally substituted with C 1-6 alkyl.

摘要翻译： 由下式（I）表示的化合物或其盐或其水合物可有效缓解由特应性疾病等引起的瘙痒：其中R表示羟基，任选被C 1-6烷氧基取代的C 1-6烷氧基或 任选被C 1-6烷基取代的氨基。

公开(公告)号：EP1992622B1

公开(公告)日：2011-07-27

申请号：EP07714569.6

申请日：2007-02-20

申请人： Eisai R&D Management Co., Ltd.

发明人： MIYAZAKI, Kazuki ,  KUSANO, Kazutomi ,  TAKASE, Yasutaka ,  ASANO, Osamu ,  SHIRATO, Manabu ,  WAKITA, Hisashi ,  ISHII, Naoto ,  SAEKI, Takao

IPC分类号： C07D239/84 ,  A61K31/517 ,  A61P17/00 ,  A61P17/04 ,  A61P37/08

CPC分类号： C07D239/84

摘要： A compound represented by the formula (I) below, a salt thereof or a hydrate of any of them is capable of effectively suppressing itch of atopic diseases and the like. (I) [In the formula, R represents a hydroxyl group, a C1-6 alkoxy group which may be substituted by a C1-6 alkoxy group, or an amino group which may be substituted by a C1-6 alkyl group.]

公开(公告)号：EP3622954A1

公开(公告)日：2020-03-18

申请号：EP18798031.3

申请日：2018-05-07

申请人： Eisai R&D Management Co., Ltd.

发明人： IDO, Katsutoshi ,  WAKITA, Hisashi ,  HATANAKA, Ken

IPC分类号： A61K31/444 ,  A61P25/14 ,  A61P43/00 ,  C07D491/147

摘要： A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has potential use as an agent for treating essential tremor, small fiber neuropathy, dystonia, epilepsy associated with Alzheimer's disease, epilepsy associated with brain tumor, or brain tumor.