公开(公告)号：EP1992622B1

公开(公告)日：2011-07-27

申请号：EP07714569.6

申请日：2007-02-20

申请人： Eisai R&D Management Co., Ltd.

发明人： MIYAZAKI, Kazuki ,  KUSANO, Kazutomi ,  TAKASE, Yasutaka ,  ASANO, Osamu ,  SHIRATO, Manabu ,  WAKITA, Hisashi ,  ISHII, Naoto ,  SAEKI, Takao

IPC分类号： C07D239/84 ,  A61K31/517 ,  A61P17/00 ,  A61P17/04 ,  A61P37/08

CPC分类号： C07D239/84

摘要： A compound represented by the formula (I) below, a salt thereof or a hydrate of any of them is capable of effectively suppressing itch of atopic diseases and the like. (I) [In the formula, R represents a hydroxyl group, a C1-6 alkoxy group which may be substituted by a C1-6 alkoxy group, or an amino group which may be substituted by a C1-6 alkyl group.]

公开(公告)号：EP1052254B1

公开(公告)日：2011-06-15

申请号：EP99900654.7

申请日：1999-01-21

申请人： Eisai R&D Management Co., Ltd.

发明人： MIYAZAKI, Kazuki ,  TAKASE, Yasutaka ,  SAEKI, Takao

IPC分类号： C07D239/84 ,  C07D215/38 ,  C07D401/12 ,  C07D401/10 ,  C07D401/04 ,  C07D405/12 ,  C07D409/04 ,  A61K31/505 ,  A61K31/47

CPC分类号： C07D215/38 ,  C07D239/84 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D471/04

摘要： Nitrogenous heterocyclic derivatives represented by formula (I) or salts or hydrates thereof, which are useful as a phosphodiesterase 4 inhibitor; and a medicine containing any of the compounds. In said formula, X and Y each represents a carbon or nitrogen atom, provided that not both of X and Y are carbon atoms; ring A represents a (hetero)aromatic ring; ring B represents an optionally substituted (un)saturated carbon ring or heterocycle; R1 represents hydrogen, halogeno, or optionally substituted alkyl or alkoxy; R?2 and R3¿ are the same or different and each represents hydrogen, optionally substituted alkyl, cycloalkyl, etc.; R?4, R5, R6, and R7¿ are the same or different and each represents hydrogen or an appropriate substituent, provided that any adjacent two of these may be bonded to form a ring; and L represents a single bond or a connecting member.

公开(公告)号：EP1992622A1

公开(公告)日：2008-11-19

申请号：EP07714569.6

申请日：2007-02-20

申请人： Eisai R&D Management Co., Ltd.

发明人： MIYAZAKI, Kazuki ,  KUSANO, Kazutomi ,  TAKASE, Yasutaka ,  ASANO, Osamu ,  SHIRATO, Manabu ,  WAKITA, Hisashi ,  ISHII, Naoto ,  SAEKI, Takao

IPC分类号： C07D239/84 ,  A61K31/517 ,  A61P17/00 ,  A61P17/04 ,  A61P37/08

CPC分类号： C07D239/84

摘要： A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like:

wherein R represents hydroxyl, C 1-6 alkoxy optionally substituted with C 1-6 alkoxy, or amino optionally substituted with C 1-6 alkyl.

摘要翻译： 由下式（I）表示的化合物或其盐或其水合物可有效缓解由特应性疾病等引起的瘙痒：其中R表示羟基，任选被C 1-6烷氧基取代的C 1-6烷氧基或 任选被C 1-6烷基取代的氨基。

公开(公告)号：EP1375496B1

公开(公告)日：2007-07-04

申请号：EP02707189.3

申请日：2002-03-27

申请人： Eisai R&D Management Co., Ltd.

发明人： OKADA, Toshimi ,  KURUSU, Nobuyuki ,  TANAKA, Keigo ,  YOSHIKAWA, Seiji ,  SHINMYO, Daisuke ,  WATANABE, Nobuhisa ,  IKUTA, Hironori ,  HIYOSHI, Hironobu ,  SAEKI, Takao ,  YANAGIMACHI, Mamoru ,  ITO, Masashi

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D451/14 ,  C07D453/02 ,  C07D491/113 ,  A61K31/435 ,  A61K31/439

CPC分类号： C07D401/04 ,  A61K31/435 ,  A61K31/439 ,  A61K31/4545 ,  C07D401/14 ,  C07D453/04 ,  C07D491/10

摘要： A compound having excellent squalene synthetase inhibitory activity. It is a compound (I) represented by the following general formula, a salt thereof, or a hydrate of either. (I) In the formula, R1 means optionally substituted vinyl or an optionally substituted aromatic ring; n is an integer of 0 to 2; X, Y, and Z are the same or different and each means optionally substituted carbon, nitrogen, etc.; CyA means an optionally substituted 5- to 14-membered nonaromatic cyclic amino group optionally containing oxygen or sulfur; W means -C=C-, etc.; and A means a group of the formula (II) (wherein R8 represents hydrogen, hydroxy, etc.; B2 represents optionally substituted carbon or nitrogen; and c is 0 or 1), etc.