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1.发明公开
公开(公告)号：EP4397317A3
公开(公告)日：2024-10-16
申请号：EP24170976.5
申请日：2018-08-30
IPC分类号： A61K31/4545 , A61P25/06 , A61K39/395 , A61K31/517
摘要： The present invention relates to combinations of lasmiditan and a calcitonin gene-related peptide (CGRP) antagonist such as rimegepant, ubrogepant, olcegepant, and MK-8031 and to methods of using the combinations for treatment of migraine, particularly migraine inadequately controlled by lasmiditan or a CGRP antagonist therapy alone, and more particularly, to treat therapy resistant migraine which is defined herein as migraine refractory to two or more prior monotherapy and/or dual therapy treatment regimens.
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公开(公告)号：EP4279132A2
公开(公告)日：2023-11-22
申请号：EP23195738.2
申请日：2019-09-03
IPC分类号： A61P25/06
摘要： The present invention relates to chronic nightly use of lasmiditan for the prevention of migraine, particularly therapy resistant migraine which is defined herein as migraine refractory to two or more prior monotherapy and/or dual therapy treatment or prevention regimens.
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公开(公告)号：EP3846810A1
公开(公告)日：2021-07-14
申请号：EP19773583.0
申请日：2019-09-03
IPC分类号： A61K31/444 , A61P25/06
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4.发明公开
公开(公告)号：EP4397317A2
公开(公告)日：2024-07-10
申请号：EP24170976.5
申请日：2018-08-30
IPC分类号： A61K39/395
CPC分类号： A61K31/4545 , A61P25/06 , A61K39/3955 , C07K16/18 , C07K2317/2420130101 , C07K2317/7620130101
摘要： The present invention relates to combinations of lasmiditan and a calcitonin gene-related peptide (CGRP) antagonist such as rimegepant, ubrogepant, olcegepant, and MK-8031 and to methods of using the combinations for treatment of migraine, particularly migraine inadequately controlled by lasmiditan or a CGRP antagonist therapy alone, and more particularly, to treat therapy resistant migraine which is defined herein as migraine refractory to two or more prior monotherapy and/or dual therapy treatment regimens.
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公开(公告)号：EP4279132A3
公开(公告)日：2024-03-06
申请号：EP23195738.2
申请日：2019-09-03
IPC分类号： A61K31/444 , A61P25/06
摘要： The present invention relates to chronic nightly use of lasmiditan for the prevention of migraine, particularly therapy resistant migraine which is defined herein as migraine refractory to two or more prior monotherapy and/or dual therapy treatment or prevention regimens.
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6.发明公开
公开(公告)号：EP3678665A1
公开(公告)日：2020-07-15
申请号：EP18766557.5
申请日：2018-08-30
IPC分类号： A61K31/4545 , A61P25/06 , A61K39/395
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