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1.发明授权
公开(公告)号：EP3066099B1
公开(公告)日：2017-09-06
申请号：EP14800188.6
申请日：2014-10-29
发明人： CHEDID, Marcio , EISSA, Hisham Omer , ENGLER, Thomas Albert , FURNESS, Kelly Wayne , RANK, Kenneth B. , WOODS, Timothy Andrew , WROBLESKI, Aaron D.
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04
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公开(公告)号：EP2714679A1
公开(公告)日：2014-04-09
申请号：EP12723323.7
申请日：2012-05-10
IPC分类号： C07D403/04 , C07D403/12 , A61K31/4439 , A61P19/02
CPC分类号： C07D233/88 , C07D401/04 , C07D401/12
摘要： The present invention provides compounds of the formula below: where A, X and R1-R6 are as described herein, a pharmaceutical salt thereof, and a pharmaceutical composition containing this compound; methods of treating pain associated with osteoarthritis using one of the compounds or a pharmaceutically acceptable salt thereof, and processes for preparing the compounds.
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公开(公告)号：EP2970221A1
公开(公告)日：2016-01-20
申请号：EP14712966.2
申请日：2014-03-07
IPC分类号： C07D403/14
CPC分类号： C07D403/14
摘要： The present invention provides isoindolinone compounds, or a pharmaceutically acceptable salt thereof, that inhibit CDC7 and, therefore may be useful in treating cancer.
摘要翻译： 本发明提供了抑制CDC7的异吲哚啉酮化合物或其药学上可接受的盐，因此可用于治疗癌症。
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公开(公告)号：EP3484875A1
公开(公告)日：2019-05-22
申请号：EP17740885.3
申请日：2017-07-10
发明人： BASTIAN, Jolie Anne , CLAYTON, Joshua Ryan , COATES, David Andrew , SALL, Daniel Jon , WOODS, Timothy Andrew
IPC分类号： C07D403/12 , A61K31/4184 , A61P35/00
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公开(公告)号：EP2970221B1
公开(公告)日：2017-06-28
申请号：EP14712966.2
申请日：2014-03-07
IPC分类号： C07D403/14
CPC分类号： C07D403/14
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6.发明公开
公开(公告)号：EP3066099A1
公开(公告)日：2016-09-14
申请号：EP14800188.6
申请日：2014-10-29
发明人： CHEDID, Marcio , EISSA, Hisham Omer , ENGLER, Thomas Albert , FURNESS, Kelly Wayne , RANK, Kenneth B. , WOODS, Timothy Andrew , WROBLESKI, Aaron D.
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04
摘要： Pyrido[2,3-d]pyrimidin-4-one compounds, formulations containing those compounds, and their use as tankyrase 1 and 2 inhibitors Formula (I).
摘要翻译： 吡啶并[2,3-d]嘧啶-4-酮化合物，含有那些化合物的制剂，以及它们作为阻聚酶1和2抑制剂式（I）的用途。
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公开(公告)号：EP3262051B1
公开(公告)日：2019-10-02
申请号：EP16706731.3
申请日：2016-02-17
发明人： HEMBRE, Erik James , LOPEZ, Jose Eduardo , MCMAHON, Jennifer Anne , RICHARDS, Simon James , WINNEROSKI, Leonard Larry, Jr. , WOODS, Timothy Andrew
IPC分类号： C07D513/04 , A61K31/542 , A61P25/28
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公开(公告)号：EP3292128A1
公开(公告)日：2018-03-14
申请号：EP16720676.2
申请日：2016-04-27
发明人： BONDAY, Zahid Quyoom , CORTEZ, Guillermo S. , DAHNKE, Karl Robert , GROGAN, Michael John , HERGUETA, Antonio Rodriguez , JAMISON, James Andrew , WATSON, Brian Morgan , WOODS, Timothy Andrew
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07H19/14 , A61K31/706 , A61K31/7068 , A61K31/7076 , C07D487/04
摘要： The present invention relates to novel 5′-substituted nucleoside compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer, in particular glioblastomas, melanoma, sarcomas, gastric cancer, pancreatic cancer, cholangiocarcinoma, bladder cancer, breast cancer, non-small cell lung cancer, leukemias including acute myeloid leukemia, and lymphomas.
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公开(公告)号：EP3262051A1
公开(公告)日：2018-01-03
申请号：EP16706731.3
申请日：2016-02-17
发明人： HEMBRE, Erik James , LOPEZ, Jose Eduardo , MCMAHON, Jennifer Anne , RICHARDS, Simon James , WINNEROSKI, Leonard Larry, Jr. , WOODS, Timothy Andrew
IPC分类号： C07D513/04 , A61K31/542 , A61P25/28
CPC分类号： C07D513/04 , A61K31/542 , A61P25/28 , C07C55/08 , C07C309/30
摘要： The present invention provides a compound of Formula II: or a pharmaceutically acceptable salt thereof.
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