公开(公告)号：EP3291906A1

公开(公告)日：2018-03-14

申请号：EP16729010.5

申请日：2016-05-03

申请人： Elicityl ,  Research Foundation For Medical Devices

发明人： BASTIDE, Ludovic ,  BONNET, Silvère ,  DARBLADE, Benoît ,  HAVET, Stéphane ,  MANDRAND, Bernard ,  RANDRIANTSOA, Mialy ,  ZERIS, Jean-Philippe

IPC分类号： B01D15/38 ,  A61M1/36

CPC分类号： B01J20/3212 ,  A61K35/16 ,  A61M1/0281 ,  A61M1/3679 ,  B01D15/3804 ,  B01D15/3809 ,  B01J20/286 ,  B01J20/3219 ,  B01J20/3274 ,  B01J20/3278 ,  G01N33/491

摘要： The invention relates to a method for the purification of a body fluid comprising antibodies corresponding to whole human or animal blood or to a product derived from human or animal blood, in which the body fluid is brought into contact with at least one substrate comprising a solid phase to which molecules of at least one oligosaccharide that can bind to one or more antibodies present in the body fluid are covalently grafted, such as to capture at least a portion of the antibodies present in the body fluid by means of bond(s) with at least some of the oligosaccharide molecules grafted to the solid phase. The method is characterised in that the solid phase carries free aldehyde (-CHO) functions.

公开(公告)号：EP3291905A1

公开(公告)日：2018-03-14

申请号：EP16727750.8

申请日：2016-05-03

申请人： Elicityl

发明人： BASTIDE, Ludovic ,  BONNET, Silvère ,  DARBLADE, Benoît ,  HAVET, Stéphane ,  MANDRAND, Bernard ,  RANDRIANTSOA, Mialy

IPC分类号： B01D15/38 ,  B01J20/24 ,  B01J20/286 ,  B01J20/32 ,  A61M1/36 ,  G01N33/49

CPC分类号： B01J20/289 ,  A61M1/3679 ,  A61M2202/0413 ,  B01D15/3804 ,  B01D15/3809 ,  B01J20/223 ,  B01J20/24 ,  B01J20/286 ,  B01J20/288 ,  B01J20/3208 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3244 ,  B01J20/3274 ,  B01J20/3278 ,  G01N33/491

摘要： The invention relates to a substrate for the purification of a body fluid, comprising a solid phase to which molecules of at least one oligosaccharide that can bind to one or more antibodies are covalently grafted, said solid phase carrying free aldehyde (-CHO) functions. The invention also relates to a method for producing such a substrate, the use of such a substrate in stabilising the antibody/oligosaccharide bond, and a method for purifying a body fluid, in which the body fluid is brought into contact with at least one substrate according to the invention, such as to capture antibodies present in the body fluid by means of bond(s) with at least some of the oligosaccharide molecules grafted to the solid phase.