公开(公告)号：EP1242379A1

公开(公告)日：2002-09-25

申请号：EP00982389.9

申请日：2000-12-04

申请人： Emory University

发明人： SNYDER, James, P. ,  DAVIS, Matthew, C. ,  ADAMS, Brian ,  SHOJI, Mamoru ,  LIOTTA, Dennis, C. ,  FERSTL, Eva, M. ,  SUNAY, Ustun, B.

IPC分类号： C07D213/63 ,  A61P35/00 ,  C07C49/235 ,  C07C49/248 ,  C07C317/10 ,  C07C33/48 ,  C07D451/02

CPC分类号： C07D295/205 ,  C07C45/292 ,  C07C45/62 ,  C07C45/74 ,  C07C49/233 ,  C07C49/235 ,  C07C49/248 ,  C07C49/255 ,  C07C49/697 ,  C07C49/747 ,  C07C49/753 ,  C07C225/22 ,  C07C235/34 ,  C07C251/40 ,  C07C275/24 ,  C07C317/10 ,  C07C321/20 ,  C07D209/34 ,  C07D213/63 ,  C07D317/50 ,  C07D451/02

摘要： The present invention is directed to curcumin analogs (I), wherein Y is OH, halogen, or CF3; Z is H, OH, OR1, halogen, or CF3; X1 and X2 are independently C or N; and A is as defined in the application; exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.