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公开(公告)号：EP2567233A1
公开(公告)日：2013-03-13
申请号：EP11777876.1
申请日：2011-04-25
IPC分类号： G01N33/536 , G01N33/533
CPC分类号： G01N21/6486 , G01N33/502 , G01N2800/44
摘要： This invention relates to multi-drug resistance (MDR) in cells, and the use of certain xanthene compounds for determining drug resistance in cells and the effect of test compounds on cell membrane transport by the membrane transporters MDRl, MRP and BCRP. Processes and kits for making these determinations and measuring these effects are described and provided.
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公开(公告)号：EP2499495B1
公开(公告)日：2016-03-30
申请号：EP10760465.4
申请日：2010-09-14
发明人： PATTON, Wayne, Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
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3.发明公开
公开(公告)号：EP2507319A2
公开(公告)日：2012-10-10
申请号：EP10795100.6
申请日：2010-11-30
发明人： PATTON, Wayne, Forrest , DAI, Lijun , LUDLAM, Anthony , YARMOLUK, Sergiy, M. , PANDE, Praveen , KOVALSKA, Vladyslava , VOLKOVA, Kateryna , COLEMAN, Jack , LOSYTSKYY, Mykhaylo , BALANDA, Anatoliy , SHEN, Dee
CPC分类号： C09B23/145 , C07D401/12 , C09B23/0008 , C09B23/0025 , C09B23/0058 , C09B23/0066 , C09B23/04 , C09B23/06 , C09B23/102 , C09B23/141 , G01N33/582 , G01N33/6845 , G01N2458/30 , G01N2800/2821 , G01N2800/2835
摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.
摘要翻译： 提供了可用于许多应用的染料和组合物，例如检测和监测蛋白质聚集，蛋白质聚集的动力学研究，神经原纤维斑块分析，蛋白质制剂稳定性的评估，蛋白质热稳定性转移测定和分子伴侣活性的分析 。 这些染料和组合物也可用作核酸和蛋白质检测中的探针。
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公开(公告)号：EP2499495A1
公开(公告)日：2012-09-19
申请号：EP10760465.4
申请日：2010-09-14
发明人： PATTON, Wayne, Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
摘要翻译： 提供了用于检测和监测自噬和磷脂沉着症，包括溶酶体贮积症发展的分析。 对于溶酶体贮积病的药物和治疗可以监测溶酶体贮积病的有效性。 候选药物和疑似毒性药物也可以筛选对细胞，组织和器官的毒性。 还提供了用于区分磷脂酶活性激活剂和自噬途径摄动剂的方法。
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公开(公告)号：EP2567233B1
公开(公告)日：2015-11-04
申请号：EP11777876.1
申请日：2011-04-25
CPC分类号： G01N21/6486 , G01N33/502 , G01N2800/44
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公开(公告)号：EP2507319B1
公开(公告)日：2019-08-28
申请号：EP10795100.6
申请日：2010-11-30
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