-
公开(公告)号：EP2499495B1
公开(公告)日：2016-03-30
申请号：EP10760465.4
申请日：2010-09-14
发明人： PATTON, Wayne, Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
-
公开(公告)号：EP2993477A1
公开(公告)日：2016-03-09
申请号：EP15187863.4
申请日：2010-09-14
发明人： PATTON, Wayne Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
摘要翻译： 提供用于检测和监测自噬和磷脂病的测定法，包括溶酶体贮积病的进展。 可以监测溶酶体储存疾病的药物和治疗溶酶体贮积病条件的有效性。 药物候选人和疑似毒素也可以筛选对细胞，组织和器官的毒性。 还提供了用于区分磷脂肪激活剂和自噬途径扰动剂的方法。
-
公开(公告)号：EP2499495A1
公开(公告)日：2012-09-19
申请号：EP10760465.4
申请日：2010-09-14
发明人： PATTON, Wayne, Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
摘要翻译： 提供了用于检测和监测自噬和磷脂沉着症，包括溶酶体贮积症发展的分析。 对于溶酶体贮积病的药物和治疗可以监测溶酶体贮积病的有效性。 候选药物和疑似毒性药物也可以筛选对细胞，组织和器官的毒性。 还提供了用于区分磷脂酶活性激活剂和自噬途径摄动剂的方法。
-
公开(公告)号：EP3001199B1
公开(公告)日：2018-03-21
申请号：EP15187858.4
申请日：2010-09-14
发明人： PATTON, Wayne Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
-
公开(公告)号：EP3001199A1
公开(公告)日：2016-03-30
申请号：EP15187858.4
申请日：2010-09-14
发明人： PATTON, Wayne Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
-
公开(公告)号：EP2993476A1
公开(公告)日：2016-03-09
申请号：EP15187852.7
申请日：2010-09-14
发明人： PATTON, Wayne Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
-
公开(公告)号：EP2993476B1
公开(公告)日：2018-12-26
申请号：EP15187852.7
申请日：2010-09-14
发明人： PATTON, Wayne Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.018 秒)
