专利检索 ap:("Epimmune, Inc.") AND inv:"TSAI, Van" 第 1 页

1.

发明授权
METHODS FOR (EX VIVO) THERAPY USING PEPTIDE-LOADED ANTIGEN PRESENTING CELLS FOR THE ACTIVATION OF CTL 失效
标题翻译：对于（离体）治疗的方法通过肽 - 放倒抗原 - CTL呈递细胞活化

公开(公告)号：EP0726941B1

公开(公告)日：2002-04-03

申请号：EP94924539.3

申请日：1994-08-01

申请人： Epimmune Inc.

发明人： CELIS, Esteban , KUBO, Ralph , SERRA, Horacio , TSAI, Van , WENTWORTH, Peggy

IPC分类号： C12N5/08 , A61K35/14 , A61K39/00 , A61P31/00 , A61P35/00

CPC分类号： C12N5/0636 , A61K2039/5158 , C12N2502/11 , Y02A50/412

摘要： Methods for activating cytotoxic T lymphocytes (CTL) in vitro are presented in conjunction with methods for using the activated CTL for therapy in vivo. Additionally, a method for killing specific CTL in vivo is presented using antigen presenting cells which were modified in vitro.

2.

发明公开
PEPTIDES AND PEPTIDE-LOADED ANTIGEN PRESENTING CELLS FOR THE ACTIVATION OF CTL 失效
标题翻译：肽和用肽LOADED，抗原呈递细胞毒性T细胞的活化

公开(公告)号：EP1012238A1

公开(公告)日：2000-06-28

申请号：EP98906086.8

申请日：1998-01-30

申请人： Epimmune, Inc.

发明人： TSAI, Van , SOUTHWOOD, Scott , SIDNEY, John , SETTE, Alessandro , CELIS, Esteban

IPC分类号： C12N5/06 , C12N5/08

CPC分类号： C12N5/0636 , A61K39/0011 , A61K2039/5158 , A61K2039/57 , C12N2501/23 , C12N2502/11 , Y02A50/412

摘要： Methods for generating antigen-specific cytotoxic T lymphocytes (CTLs) in vitro are presented in conjuntion with methods for using these CTLs for therapy in vivo. The antigen presenting cells (APCs) used herein notably include dentritic cells pretreated with GM-CSF and IL-4. Antigen-specific CTLs were obtained by incubating CD8 preparations in the presence of APCs that bound desired peptides. IL-7 was generally added at day 1 of the incubation; IL-10 was generally added one day later and during restimulation. The invention also comprises methods for using peptide pulsed dentritic cells to identify novel MHC Class I-restricted tumor antigens and subdominant epitopes.