公开(公告)号：EP1608672A2

公开(公告)日：2005-12-28

申请号：EP04749728.4

申请日：2004-04-02

申请人： Epimmune Inc.

发明人： TANGRI, Shabnam ,  MOTHE, Bianca ,  SETTE, Alessandro ,  SOUTHWOOD, Scott ,  BRIGGS, Kristen ,  CHESTNUT, Robert, W.

IPC分类号： C07K1/00

CPC分类号： C07K14/505 ,  A61K38/00 ,  C07K14/55

摘要： The subject invention provides peptides, polypeptides, proteins and/or antibodies of reduced immunogenicity. Also provided are methods of reducing the immunogenicity of peptides, polypeptides, proteins and/or antibodies. In certain embodiments, the immunogenicity of therapeutic peptides, polypeptides, proteins, and/or antibodies such as hormones, growth factors, and cytokines is reduced.

公开(公告)号：EP1495322A2

公开(公告)日：2005-01-12

申请号：EP03718231.8

申请日：2003-04-07

申请人： Epimmune Inc.

发明人： ISHIOKA, Glenn ,  FIKES, John ,  TANGRI, Shabnam ,  SETTE, Alessandro

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K38/04 ,  A61K39/00 ,  C07H21/04

CPC分类号： C07K14/70539 ,  C07K14/4748 ,  C07K14/70503

摘要： Heteroclitic analogs of class I epitopes are prepared by providing convervative, semi-conservative, or non-conservative amino acid substitutions at positions 3 and/or 4 and/or 5 and/or 6 and/or 7 and/or 8 and/or 9 and/or 10 of these epitopes. The analogs are useful in eliciting immune responses with respect to the corresponding wild-type epitopes.

公开(公告)号：EP1230268A2

公开(公告)日：2002-08-14

申请号：EP00979208.6

申请日：2000-11-20

申请人： Epimmune, Inc.

发明人： TANGRI, Shabnam ,  SETTE, Alessandro ,  ISHIOKA, Glenn

IPC分类号： C07K14/705 ,  C07K7/06 ,  A61K39/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/555 ,  C07K7/06 ,  C07K7/08 ,  C07K14/70503 ,  C07K14/70539 ,  C07K14/71 ,  C07K2319/00

摘要： Heteroclitic analogs of Class I epitopes are prepared by providing conservative or semi-conservative amino acid substitutions at positions 3 and/or 5 and/or 7 of these epitopes. The analogs are useful in eliciting immune responses with respect to the corresponding wildtype epitopes.