公开(公告)号：EP3838269A1

公开(公告)日：2021-06-23

申请号：EP19216548.8

申请日：2019-12-16

申请人： European Molecular Biology Laboratory

发明人： Typas, Athanasios ,  Maier, Lisa ,  Goemans, Camilie ,  Gontao Brochado, Ana Rita ,  Cacace, Elisabetta

IPC分类号： A61K31/00 ,  A61K31/65 ,  A61K31/7048 ,  A61K31/7052 ,  A61K45/06 ,  A61P1/00 ,  A61P1/14 ,  A61K31/05 ,  A61K31/343 ,  A61K31/37 ,  A61K31/7056 ,  A61K31/196 ,  A61K31/197 ,  A61K31/4152

摘要： The present invention relates to the field of therapeutics and, more in particular, to pharmaceutical compositions for the prevention and/or treatment of bacterial infections and antibacterial-induced dysfunctions. The invention is based on the identification of compounds that prevent antibacterial effects of antibiotics on microbiome-bacterial species, while retaining antibacterial effects of antibiotics on pathogenic bacteria. The invention also pertains to pharmaceutical compositions comprising antibiotics and antibiotic antidotes for the protection of commensal microbiome-bacteria. Thus, this invention relates to compounds and pharmaceutical combinations useful to prevent antibiotic-induced adverse effects on the gut microbiome. Furthermore provided are methods for preventing an adverse effect on a gut microbiome using the compounds and/or pharmaceutical compositions of this invention.