公开(公告)号：EP1461313B1

公开(公告)日：2009-08-05

申请号：EP02784794.6

申请日：2002-12-13

申请人： Exelixis, Inc.

发明人： BROWN, S., David ,  CANNE, Lynne ,  CO, Erick, W. ,  JAMMALAMADAKA, Vasu ,  KHOURY, Richard, G. ,  KIM, Moon Hwan ,  LE, Donna, T. ,  LEW, Amy ,  MAC, Morrison, B. ,  MAMO, Shumeye ,  NUSS, John, M. ,  PRISBYLLA, Michael, P. ,  XU, Wei

IPC分类号： C07C311/19 ,  C07C311/29 ,  C07C259/06 ,  C07C259/08 ,  C07D213/32 ,  C07D213/68 ,  A61K31/16 ,  A61K31/44 ,  A61P19/02 ,  A61P35/00

CPC分类号： C07D409/04 ,  C07C311/29 ,  C07C2601/14 ,  C07D207/09 ,  C07D211/34 ,  C07D213/56 ,  C07D213/65 ,  C07D213/70 ,  C07D233/48 ,  C07D233/64 ,  C07D295/13 ,  C07D295/15 ,  C07D295/185 ,  C07D295/215 ,  C07D311/70

摘要： The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chorides and ADAM-10 modulators therefrom.

摘要翻译： 本发明提供了可用于抑制ADAM-10蛋白质的化合物。 这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含根据本发明的一种或多种ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗癌症，关节炎和与血管生成有关的疾病。 相应地，本发明还包括治疗癌症形式，关节炎和与血管生成相关的疾病的方法，其中ADAM-10起关键作用。 本发明还提供从其制备双芳基醚磺酰氯和ADAM-10调节剂的方法。

公开(公告)号：EP1461313A1

公开(公告)日：2004-09-29

申请号：EP02784794.6

申请日：2002-12-13

申请人： Exelixis, Inc.

发明人： BROWN, S., David ,  CANNE, Lynne ,  CO, Erick, W. ,  JAMMALAMADAKA, Vasu ,  KHOURY, Richard, G. ,  KIM, Moon Hwan ,  LE, Donna, T. ,  LEW, Amy ,  MAC, Morrison, B. ,  MAMO, Shumeye ,  NUSS, John, M. ,  PRISBYLLA, Michael, P. ,  XU, Wei

IPC分类号： C07C311/19 ,  C07C311/29 ,  C07C259/06 ,  C07C259/08 ,  C07D213/32 ,  C07D213/68 ,  A61K31/16 ,  A61K31/44 ,  A61P19/02 ,  A61P35/00

CPC分类号： C07D409/04 ,  C07C311/29 ,  C07C2601/14 ,  C07D207/09 ,  C07D211/34 ,  C07D213/56 ,  C07D213/65 ,  C07D213/70 ,  C07D233/48 ,  C07D233/64 ,  C07D295/13 ,  C07D295/15 ,  C07D295/185 ,  C07D295/215 ,  C07D311/70

摘要： The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chorides and ADAM-10 modulators therefrom.