公开(公告)号：EP2350121A1

公开(公告)日：2011-08-03

申请号：EP09748796.1

申请日：2009-11-10

申请人： Fändrich, Fred

发明人： KUNZENDORF, Ulrich ,  KRAUTWALD, Stefan

IPC分类号： C07K14/065 ,  A61K38/55 ,  C07K14/81

CPC分类号： C07K14/8121 ,  A61K38/00 ,  C07K14/005 ,  C07K14/811 ,  C07K2319/10 ,  C12N2710/24122

摘要： The present invention relates to a fusion protein comprising a protein transduction domain capable of introducing the fusion protein into a mammalian cell and an anti-apoptotic protein comprising the amino acid of the sequence of SEQ ID NO:1 or an anti-apoptotically active variant or fragment thereof. The invention also relates to a pharmaceutical composition comprising such a fusion protein, in particular for blocking apoptosis in a patient in need thereof. The invention also provides a polynucleotide encoding such a fusion protein, an expression vector comprising the polynucleotide and a host cell comprising the expression vector. In a further aspect, the invention relates to the use of any of theses materials for the preparation of a medicament for blocking apoptosis in a patient in need thereof.

公开(公告)号：EP2350121B1

公开(公告)日：2013-02-27

申请号：EP09748796.1

申请日：2009-11-10

申请人： Fändrich, Fred

发明人： KUNZENDORF, Ulrich ,  KRAUTWALD, Stefan

IPC分类号： C07K14/065 ,  A61K38/55 ,  C07K14/81

CPC分类号： C07K14/8121 ,  A61K38/00 ,  C07K14/005 ,  C07K14/811 ,  C07K2319/10 ,  C12N2710/24122

摘要： The present invention relates to a fusion protein comprising a protein transduction domain capable of introducing the fusion protein into a mammalian cell and an anti-apoptotic protein comprising the amino acid of the sequence of SEQ ID NO:1 or an anti-apoptotically active variant or fragment thereof. The invention also relates to a pharmaceutical composition comprising such a fusion protein, in particular for blocking apoptosis in a patient in need thereof. The invention also provides a polynucleotide encoding such a fusion protein, an expression vector comprising the polynucleotide and a host cell comprising the expression vector. In a further aspect, the invention relates to the use of any of theses materials for the preparation of a medicament for blocking apoptosis in a patient in need thereof.

摘要翻译： 本发明涉及包含能够将融合蛋白引入哺乳动物细胞的蛋白转导结构域的融合蛋白和包含SEQ ID NO：1的序列的氨基酸的抗凋亡蛋白或抗凋亡活性变体或 片段。 本发明还涉及包含这种融合蛋白的药物组合物，特别是用于在有需要的患者中阻断细胞凋亡。 本发明还提供编码这种融合蛋白的多核苷酸，包含该多核苷酸的表达载体和包含该表达载体的宿主细胞。 在另一方面，本发明涉及任何这些材料用于制备用于在有需要的患者中阻断细胞凋亡的药物的用途。