公开(公告)号：EP1896614A1

公开(公告)日：2008-03-12

申请号：EP06776042.1

申请日：2006-06-07

申请人： F. HOFFMANN-LA ROCHE AG

发明人： ESSIOUX, Laurent ,  FOERNZLER, Dorothée ,  HASHIMOTO, Lara ,  LINDPAINTNER, Klaus ,  RASHFORD, Michelle ,  SPLEISS, Olivia ,  TRUMAN, Matt ,  VOULGARI, Athina

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

摘要： The present invention concerns a method for the prediction of acute renal transplant rejection by detecting a polymorphism in exon 26 of the MDRl gene, optionally in combination with polymorphisms of the IMPDH2 and IL 10 genes which were found to be associated with this disease.

公开(公告)号：EP1896609A1

公开(公告)日：2008-03-12

申请号：EP06754195.3

申请日：2006-06-07

申请人： F. Hoffmann-La Roche AG

发明人： ESSIOUX, Laurent ,  FOERNZLER, Dorothee ,  HASHIMOTO, Lara ,  LINDPAINTNER, Klaus ,  RASHFORD, Michelle ,  SPLEISS, Olivia ,  TRUMAN, Matt ,  VOULGARI, Athina

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention concerns a method for the prediction of acute renal transplant rejection by detecting a polymorphism in intron 7 of the IMPDH2 gene, optionally in combination with polymorphisms of the MDRl and IL 10 genes which were found to be associated with this disease.

公开(公告)号：EP1896608A1

公开(公告)日：2008-03-12

申请号：EP06754194.6

申请日：2006-06-07

申请人： F. Hoffmann-La Roche AG

发明人： ESSIOUX, Laurent ,  FOERNZLER, Dorothee ,  HASHIMOTO, Lara ,  LINDPAINTNER, Klaus ,  RASHFORD, Michelle ,  SPLEISS, Olivia ,  TRUMAN, Matt ,  VOULGARI, Athina

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

摘要： The present invention concerns a method for the prediction of acute renal transplant rejection by detecting a polymorphism in the promoter region of the IL 10 gene, optionally in combination with polymorphisms of the MDRl and IMPDH2 genes which were found to be associated with this disease.