公开(公告)号：EP2173735B1

公开(公告)日：2012-01-11

申请号：EP08774212.8

申请日：2008-06-23

申请人： F. Hoffmann-La Roche AG

发明人： AEBI, Johannes ,  BINGGELI, Alfred ,  GREEN, Luke ,  HARTMANN, Guido ,  MAERKI, Hans P. ,  MATTEI, Patrizio ,  RICKLIN, Fabienne ,  ROCHE, Olivier

IPC分类号： C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  A61K31/4178 ,  A61K31/4439 ,  A61P9/00

CPC分类号： C07D401/14 ,  C07D401/06 ,  C07D403/06 ,  C07D405/14

摘要： The invention is concerned with novel imidazole derivatives of formula (I), wherein (Ia), m, E, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR- 2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.

公开(公告)号：EP1907388A1

公开(公告)日：2008-04-09

申请号：EP06764077.1

申请日：2006-07-05

申请人： F. Hoffmann-La Roche AG

发明人： BOEHRINGER, Markus ,  GROEBKE ZBINDEN, Katrin ,  HAAP, Wolfgang ,  HILPERT, Hans ,  PANDAY, Narendra ,  RICKLIN, Fabienne

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/4162 ,  A61K31/4355 ,  A61K31/4375 ,  A61P7/02

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The invention is concerned with novel heteroaryl fused cyclic amines of formula (I) wherein A, X1 to X3, Y1 to Y3, Z, R1, R2, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.

摘要翻译： 本发明涉及式（I）的新型杂芳基稠合环胺，其中A，X 1至X 3，Y 1至Y 3，Z，R 1，R 2，m和n如说明书和权利要求书中所定义，以及生理学上 其可接受的盐。 这些化合物抑制凝血因子Xa并可用作药物。

公开(公告)号：EP4263541A1

公开(公告)日：2023-10-25

申请号：EP21836543.5

申请日：2021-12-16

申请人： F. Hoffmann-La Roche AG

发明人： DOLENTE, Cosimo ,  HEWINGS, David Stephen ,  HUNZIKER, Daniel ,  JUNG, Erik ,  PETTAZZONI, Piergiorgio Francesco Tommaso ,  RICKLIN, Fabienne ,  RIEMER, Claus ,  WICHMANN, Juergen

IPC分类号： C07D471/04 ,  A61P35/00 ,  A61K31/519

公开(公告)号：EP3134402B1

公开(公告)日：2020-05-06

申请号：EP15716824.6

申请日：2015-04-20

申请人： F. Hoffmann-La Roche AG

发明人： HOVES, Sabine ,  KUHN, Bernd ,  RICKLIN, Fabienne ,  ROEVER, Stephan

IPC分类号： C07D471/04 ,  A61K31/4188 ,  A61K31/437 ,  A61P35/00 ,  A61P31/00 ,  A61P37/02

公开(公告)号：EP3134402A1

公开(公告)日：2017-03-01

申请号：EP15716824.6

申请日：2015-04-20

申请人： F. Hoffmann-La Roche AG

发明人： HOVES, Sabine ,  KUHN, Bernd ,  RICKLIN, Fabienne ,  ROEVER, Stephan

IPC分类号： C07D471/04 ,  A61K31/4188 ,  A61K31/437 ,  A61P35/00 ,  A61P31/00 ,  A61P37/02

摘要： This invention relates to novel 4-amino-imidazoquinoline compounds of the formula wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer or infectious diseases.

摘要翻译： 本发明涉及下式的新的4-氨基 - 咪唑并喹啉化合物，其中R 1至R 4如说明书和权利要求书中所定义，以及其药学上可接受的盐。 这些化合物是TLR激动剂，因此可用作治疗诸如癌症或感染性疾病的疾病的药物。

公开(公告)号：EP2205583A2

公开(公告)日：2010-07-14

申请号：EP08804525.7

申请日：2008-09-22

申请人： F. Hoffmann-La Roche AG

发明人： AEBI, Johannes ,  BINGGELI, Alfred ,  GREEN, Luke ,  HARTMANN, Guido ,  MAERKI, Hans P. ,  MATTEI, Patrizio ,  RICKLIN, Fabienne ,  ROCHE, Olivier

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D211/58 ,  C07D243/08 ,  A61K31/551 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61P9/00 ,  A61P29/00 ,  C07D413/14 ,  C07D403/06

CPC分类号： C07D211/58 ,  C07D295/192 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/06

摘要： The invention is concerned with novel biaryl derivatives of Formula (I), wherein Formula (A), m, R1, R2, R3, X1, X2 and X3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.

公开(公告)号：EP2029601B1

公开(公告)日：2010-06-02

申请号：EP07729022.9

申请日：2007-05-11

申请人： F. Hoffmann-La Roche AG

发明人： CONTE, Aurelia ,  DEHMLOW, Henrietta ,  GRETHER, Uwe ,  KRATOCHWIL, Nicole A. ,  KUEHNE, Holger ,  NARQUIZIAN, Robert ,  PANOUSIS, Constantinos ,  PETERS, Jens-Uwe ,  RICKLIN, Fabienne ,  ROEVER, Stephan

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P3/06

CPC分类号： C07D471/04

摘要： The invention is concerned with novel pyridopyrimidinone derivatives of formula (I), wherein R1 to R8, X, Y, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.

公开(公告)号：EP2307387B1

公开(公告)日：2013-11-20

申请号：EP09780158.3

申请日：2009-07-06

申请人： F. Hoffmann-La Roche AG

发明人： AEBI, Johannes ,  BINGGELI, Alfred ,  GREEN, Luke ,  HARTMANN, Guido ,  MAERKI, Hans, P. ,  MATTEI, Patrizio ,  RICKLIN, Fabienne ,  ROCHE, Olivier

IPC分类号： C07D241/08 ,  C07D243/08 ,  C07D285/36 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/14 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/551 ,  A61P9/10

CPC分类号： C07D403/06 ,  C07D241/08 ,  C07D243/08 ,  C07D285/36 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14

摘要： The invention is concerned with novel heterocyclyl compounds of formula (I) wherein A, X, Y1, Y2, Y3, R3, R4, R5, R6, R7, R8, R9, R10, m, n and p are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR2 receptor, CCR5 receptor and/or CCR3 receptor and can be used as medicaments.

公开(公告)号：EP2297137A1

公开(公告)日：2011-03-23

申请号：EP09765762.1

申请日：2009-06-08

申请人： F. Hoffmann-La Roche AG

发明人： ADAM, Jean-Michel ,  AEBI, Johannes ,  BINGGELI, Alfred ,  GREEN, Luke ,  HARTMANN, Guido ,  MAERKI, Hans P. ,  MATTEI, Patrizio ,  RICKLIN, Fabienne ,  ROCHE, Olivier

IPC分类号： C07D401/14 ,  C07D471/04 ,  A61K31/437 ,  A61K31/4468 ,  A61P9/00 ,  A61P25/00 ,  A61P19/02 ,  A61P1/00

CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D471/04

摘要： The invention is concerned with novel heteroaryl carboxamide derivatives of Formula (I), wherein (II), m, X, Y, R
1 , R
2 , R
3 and R
4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.

摘要翻译： （II），m，X，Y，R 1，R 2，R 3和R 4如说明书和权利要求中所定义 作为其生理上可接受的盐。 这些化合物是CCR-2受体，CCR-5受体和/或CCR-3受体的拮抗剂，可以用作药物。

公开(公告)号：EP2010506B1

公开(公告)日：2010-08-04

申请号：EP07727958.6

申请日：2007-04-11

申请人： F. Hoffmann-La Roche AG

发明人： AEBI, Johannes ,  GREEN, Luke ,  MATTEI, Patrizio ,  RICKLIN, Fabienne ,  ROCHE, Olivier ,  ZAHM, Peter

IPC分类号： C07D243/14 ,  C07D405/12 ,  C07D401/06 ,  C07D401/14 ,  C07D401/12 ,  C07D403/06 ,  C07D471/10 ,  A61K31/551 ,  C07D403/12 ,  C07D405/06 ,  C07D413/12

CPC分类号： C07D405/06 ,  C07D243/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/10

摘要： The invention is concerned with novel diazepan derivatives of formula (I) wherein A, X, R3, R4, R5, R6, R8, R9, R10, R11, R12, R13, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.