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1.发明授权PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS 有权吡啶并[2,3-d]嘧啶-2,4-二胺化合物作为抑制剂的PTP1B
公开(公告)号：EP1910359B1
公开(公告)日：2009-11-18
申请号：EP06777692.2
申请日：2006-07-11
发明人： BERTHEL, Steven, Joseph , CHEUNG, Adrian, Wai-Hing , KIM, Kyungjin , LI, Shiming , THAKKAR, Kshitij, Chhabilbhai , YUN, Weiya
IPC分类号： C07D471/04 , A61P3/00 , A61K31/519
CPC分类号： C07D471/04
摘要： The present invention is concerned with compounds of formula (I) wherein R1, R2, R3, R4 and X are as described in the description and claims. The compounds are inhibitors of PTP1B. Accordingly, the compounds can be used for treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
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2.发明公开DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS 有权DIAMINOPYRROLOQUINAZOLINE AS酪氨酸磷酸酶抑制剂蛋白质
公开(公告)号：EP1633754A1
公开(公告)日：2006-03-15
申请号：EP04731898.5
申请日：2004-05-10
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： This Invention relates to diaminopyrroloquinazoline compounds of formula (I) wherein R1, R2, R3, Ra, Rb, Rc, Rd, Re, Rf and A are as defined in the description and Claims, which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.
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3.发明公开PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS 有权吡啶并[2,3-d]嘧啶-2,4-二胺化合物作为抑制剂的PTP1B
公开(公告)号：EP1910359A1
公开(公告)日：2008-04-16
申请号：EP06777692.2
申请日：2006-07-11
发明人： BERTHEL, Steven, Joseph , CHEUNG, Adrian, Wai-Hing , KIM, Kyungjin , LI, Shiming , THAKKAR, Kshitij, Chhabilbhai , YUN, Weiya
IPC分类号： C07D471/04 , A61P3/00 , A61K31/519
CPC分类号： C07D471/04
摘要： The present invention is concerned with compounds of formula (I) wherein R1, R2, R3, R4 and X are as described in the description and claims. The compounds are inhibitors of PTP1B. Accordingly, the compounds can be used for treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
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4.发明授权DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS 有权DIAMINOPYRROLOCHINAZOLINE蛋白酪氨酸磷酸酶抑制剂
公开(公告)号：EP1628979B1
公开(公告)日：2008-03-19
申请号：EP04731581.7
申请日：2004-05-07
发明人： BERTHEL, Steven, Joseph , CHEUNG, Adrian Wai-Hing , KIM, Kyungjin , THAKKAR, Kshitij, Chhabilbhai , YUN, Weiya
IPC分类号： C07D487/04 , A61K31/517 , A61P5/50
CPC分类号： C07D487/04
摘要： The invention relates to diaminopyrroloquinazoline compounds of formula (I) wherein R1, Ra, Rb, Rc, Rd, Re, Rf and A are as defined in the specification and claims, which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.
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5.发明授权DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS 有权DIAMINOPYRROLOQUINAZOLINE ALS蛋白酪氨酸磷酸酶抑制剂
公开(公告)号：EP1633754B1
公开(公告)日：2008-06-11
申请号：EP04731898.5
申请日：2004-05-10
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： This Invention relates to diaminopyrroloquinazoline compounds of formula (I) wherein R1, R2, R3, Ra, Rb, Rc, Rd, Re, Rf and A are as defined in the description and Claims, which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.
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公开(公告)号：EP1572670A1
公开(公告)日：2005-09-14
申请号：EP03767788.7
申请日：2003-12-11
发明人： CHEN, Shaoqing , CORBETT, Wendy, Lea , GUERTIN, Kevin, Richard , HAYNES, Nancy-Ellen , KESTER, Robert, Francis , MENNONA, Francis, A. , MISCHKE, Steven, Gregory , QIAN, Yimin , SARABU, Ramakanth , SCOTT, Nathan, Robert , THAKKAR, Kshitij, Chhabilbhai
IPC分类号： C07D241/26 , A61P3/10 , A61K31/50 , C07D213/78 , C07D241/20 , C07D213/76 , C07D213/75 , C07D413/04 , C07D417/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D403/04 , C07D409/04 , A61K31/501 , A61K31/44 , A61K31/4436
CPC分类号： C07D213/75 , C07D213/76 , C07D213/78 , C07D241/20 , C07D241/26 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D417/06
摘要： The present invention provides a compound according to formula (I) where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula (I) are also provided, said compounds being glucokinase activators which are useful in the treatment of type II diabetes.
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公开(公告)号：EP1572670B1
公开(公告)日：2007-08-22
申请号：EP03767788.7
申请日：2003-12-11
发明人： CHEN, Shaoqing , CORBETT, Wendy, Lea , GUERTIN, Kevin, Richard , HAYNES, Nancy-Ellen , KESTER, Robert, Francis , MENNONA, Francis, A. , MISCHKE, Steven, Gregory , QIAN, Yimin , SARABU, Ramakanth , SCOTT, Nathan, Robert , THAKKAR, Kshitij, Chhabilbhai
IPC分类号： C07D241/26 , A61P3/10 , A61K31/50 , C07D213/78 , C07D241/20 , C07D213/76 , C07D213/75 , C07D413/04 , C07D417/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D403/04 , C07D409/04 , A61K31/501 , A61K31/44 , A61K31/4436
CPC分类号： C07D213/75 , C07D213/76 , C07D213/78 , C07D241/20 , C07D241/26 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D417/06
摘要： The present invention provides a compound according to formula (I) where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula (I) are also provided, said compounds being glucokinase activators which are useful in the treatment of type II diabetes.
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8.发明公开DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS 有权DIAMINOPYRROLOCHINAZOLINE蛋白酪氨酸磷酸酶抑制剂
公开(公告)号：EP1628979A1
公开(公告)日：2006-03-01
申请号：EP04731581.7
申请日：2004-05-07
发明人： BERTHEL, Steven, Joseph , CHEUNG, Adrian Wai-Hing , KIM, Kyungjin , THAKKAR, Kshitij, Chhabilbhai , YUN, Weiya
IPC分类号： C07D487/04 , A61K31/517 , A61P5/50
CPC分类号： C07D487/04
摘要： The invention relates to diaminopyrroloquinazoline compounds of formula (I) wherein R1, Ra, Rb, Rc, Rd, Re, Rf and A are as defined in the specification and claims, which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.
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