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公开(公告)号：EP1315727A2
公开(公告)日：2003-06-04
申请号：EP01980258.6
申请日：2001-08-22
发明人： ARZENO, Humberto, Bartolome , CHEN, Jian, Jeffrey , DUNN, James, Patrick , GOLDSTEIN, David, Michael , LIM, Julie, Anne
IPC分类号： C07D471/04 , A61K31/519 , A61P25/00 , C07D239/46
CPC分类号： C07D239/47 , C07D471/04
摘要： The present invention provides compounds of the formula (I) a prodrug or a pharmaceutically acceptable salt thereof, wherein R?1, R2, R3 and Ar1¿ are those defined herein, and processes for their preparation and their use for the treatment of p38 mediated disorders.
摘要翻译： 本发明提供了式（I）化合物，其前药或药学上可接受的盐，其中R 1，R 2，R 3和Ar 1是本文所定义的那些化合物及其制备方法和它们用于治疗p38介导的用途 障碍。
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公开(公告)号：EP2164835A2
公开(公告)日：2010-03-24
申请号：EP08759781.1
申请日：2008-05-20
IPC分类号： C07D249/10
CPC分类号： C07D249/12 , C07C17/18 , C07C45/004 , C07C253/14 , C07C253/30 , C07C25/18 , C07C47/55 , C07C255/54 , C07C255/56
摘要： The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles (2) which are useful intermediates in a new process for the preparation of triazolones (20).
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公开(公告)号：EP2164835B1
公开(公告)日：2012-12-12
申请号：EP08759781.1
申请日：2008-05-20
IPC分类号： C07D249/12 , C07D249/10 , C07C205/11 , C07C253/14 , C07C253/30 , C07C17/18 , C07C45/00
CPC分类号： C07D249/12 , C07C17/18 , C07C45/004 , C07C253/14 , C07C253/30 , C07C25/18 , C07C47/55 , C07C255/54 , C07C255/56
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公开(公告)号：EP1315727B1
公开(公告)日：2005-06-29
申请号：EP01980258.6
申请日：2001-08-22
发明人： ARZENO, Humberto, Bartolome , CHEN, Jian, Jeffrey , DUNN, James, Patrick , GOLDSTEIN, David, Michael , LIM, Julie, Anne
IPC分类号： C07D471/04 , A61K31/519 , A61P25/00 , C07D239/46
CPC分类号： C07D239/47 , C07D471/04
摘要： The present invention provides compounds of the formula (I) a prodrug or a pharmaceutically acceptable salt thereof, wherein R?1, R2, R3 and Ar1¿ are those defined herein, and processes for their preparation and their use for the treatment of p38 mediated disorders.
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