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1.发明公开7-ARYL-6(Z)HEPTATRIENOIC ACID RETINAMIDES AS APOPTOSIS INDUCING COMPOUNDS AND THEIR USE AS ANTI-CANCER AGENTS 有权7-芳基 - 6（Z）HEPTATRIENSÄURE视黄AS凋亡诱导化合物及其作为抗癌药
公开(公告)号：EP1149067A1
公开(公告)日：2001-10-31
申请号：EP99963486.8
申请日：1999-12-10
IPC分类号： C07C233/29 , A61K31/165 , A61P35/00 , C07C235/38
CPC分类号： C07C233/29 , C07C235/38
摘要： Novel trienoic retinoid compounds of formula (I) wherein R1 - R7 are as defined in the specification, possess apoptotic activity and are useful for the prevention and treatment of cancer.
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2.发明公开SULFONAMIDE SUBSTITUTED XANTHINE DERIVATIVES FOR USE AS PEPCK INHIBITORS 有权SULFONAMIDSUBSTITUIERTE克桑西衍生物FOR USE AS PEPCK抑制剂
公开(公告)号：EP1599477A1
公开(公告)日：2005-11-30
申请号：EP04710346.0
申请日：2004-02-12
发明人： FOLEY, Louise, Helen , HUBY, Nicholas, John, Silvester , PIETRANICO-COLE, Sherrie, Lynn , YUN, Weiya , DUNTEN, Pete, William
IPC分类号： C07D473/04 , A61K31/52 , A61P3/10
CPC分类号： C07D473/04 , C07D473/06 , C07D473/08
摘要： The present invention is concerned with sulfonamide substituted xanthine derivatives of formula (I) or a pharmaceutically acceptable salts or prodrugs thereof, wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (I) and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.
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3.发明授权AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY 有权阿米德黄嘌呤糖异生调控作用取代衍生物
公开(公告)号：EP1515972B1
公开(公告)日：2009-05-13
申请号：EP03735559.1
申请日：2003-06-05
发明人： DUNTEN, Pete, William , FOLEY, Louise, Helen , HUBY, Nicholas, John, Silvester , PIETRANICO-COLE, Sherrie, Lynn , YUN, Weiya
IPC分类号： C07D473/02 , A61K31/52 , A61P3/10
CPC分类号： C07D473/04 , C07D473/02 , C07D473/06
摘要： The present invention is a 1,3,8 substituted xanthine derivative of formula (I) or a pharmaceutically acceptable salt thereof, wherein R , R and R are as defined in the specification. Compounds of formula (I) and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.
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公开(公告)号：EP1153015B1
公开(公告)日：2004-09-29
申请号：EP00907524.3
申请日：2000-02-09
IPC分类号： C07D239/62 , A61K31/515 , A61P35/00
CPC分类号： C07D239/62 , A61K31/513
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5.发明授权7-ARYL-6(Z)HEPTATRIENOIC ACID RETINAMIDES AS APOPTOSIS INDUCING COMPOUNDS AND THEIR USE AS ANTI-CANCER AGENTS 有权7-芳基 - 6（Z）HEPTATRIENSÄURE视黄AS凋亡诱导化合物及其作为抗癌药
公开(公告)号：EP1149067B1
公开(公告)日：2004-02-25
申请号：EP99963486.8
申请日：1999-12-10
IPC分类号： C07C233/29 , A61K31/165 , A61P35/00 , C07C235/38
CPC分类号： C07C233/29 , C07C235/38
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6.发明公开
公开(公告)号：EP1153015A1
公开(公告)日：2001-11-14
申请号：EP00907524.3
申请日：2000-02-09
IPC分类号： C07D239/62 , A61K31/515 , A61P35/00
CPC分类号： C07D239/62 , A61K31/513
摘要： The novel compounds of formula (I) wherein R1 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substitued alkynyl, alkoxy, substituted alkoxy, aryloxy or alkylalkoxy, and R2 is aryloxy; pharmaceutically acceptable salts of an acidic compound of formula (I), and prodrugs thereof can be used in the treatment or control of cancer associated with overexpression of gelatinase-A and/or gelatinase-B, particularly skin cancer, breast cancer, prostate cancer, colon cancer, lung cancer, and gastric cancer, and are also useful for other diseases associated with unregulated degradation of extracellular matrix, including rheumatoid arthritis, osteoarthritis, multiple sclerosis, corneal ulceration, periodontal disease and the like.
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7.发明授权
公开(公告)号：EP1599477B1
公开(公告)日：2008-01-30
申请号：EP04710346.0
申请日：2004-02-12
发明人： FOLEY, Louise, Helen , HUBY, Nicholas, John, Silvester , PIETRANICO-COLE, Sherrie, Lynn , YUN, Weiya , DUNTEN, Pete, William
IPC分类号： C07D473/04 , A61K31/52 , A61P3/10
CPC分类号： C07D473/04 , C07D473/06 , C07D473/08
摘要： The present invention is concerned with sulfonamide substituted xanthine derivatives of formula (I) or a pharmaceutically acceptable salts or prodrugs thereof, wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (I) and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.
摘要翻译： 本发明涉及式（I）的磺酰胺取代的黄嘌呤衍生物或其药学上可接受的盐或前药，其中R 1，R 2和R 3如说明书中所定义。 式（I）化合物及其药学上可接受的盐或前药显示出作为糖异生的调节剂的活性。
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8.发明公开AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY 有权阿米德黄嘌呤糖异生调控作用取代衍生物
公开(公告)号：EP1515972A1
公开(公告)日：2005-03-23
申请号：EP03735559.1
申请日：2003-06-05
发明人： DUNTEN, Pete, William , FOLEY, Louise, Helen , HUBY, Nicholas, John, Silvester , PIETRANICO-COLE, Sherrie, Lynn , YUN, Weiya
IPC分类号： C07D473/02 , A61K31/52 , A61P3/10
CPC分类号： C07D473/04 , C07D473/02 , C07D473/06
摘要： The present invention is a 1,3,8 substituted xanthine derivative of formula (I) or a pharmaceutically acceptable salt thereof, wherein R , R and R are as defined in the specification. Compounds of formula (I) and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.
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