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164 条记录 (耗时 0.026 秒)

    MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS
    2.
    发明授权
    MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS 有权
    Meldrum酸，巴比妥酸及吡衍生物与羟胺取代的HNO DONORS

    公开(公告)号：EP2776402B1

    公开(公告)日：2017-07-26

    申请号：EP12781538.9

    申请日：2012-10-16

    申请人： The Johns Hopkins University

    发明人： GUTHRIE, Daryl A. ,  TOSCANO, John, P.

    IPC分类号： C07D231/22 ,  C07D231/46 ,  C07D239/62 ,  C07D319/06 ,  A61K31/4155 ,  A61K31/515 ,  A61K31/357 ,  A61K31/366 ,  A61P9/00 ,  A61P35/00

    CPC分类号： C07D319/06 ,  C07D231/08 ,  C07D231/22 ,  C07D231/46 ,  C07D239/62

    摘要： The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

    摘要翻译： 所公开的主题提供了某些N-取代的羟胺衍生物化合物，包含此类化合物的药物组合物和试剂盒以及使用此类化合物或药物组合物的方法。 特别地，所公开的主题提供了一种使用这样的化合物或用于治疗，预防，或延缓疾病或病症的发作和/或发展的药物组合物的方法。 在一些实施方案中，所述疾病或病症选自心血管疾病，局部缺血，再灌注损伤，癌性疾病，肺动脉高压和响应于硝酰基疗法条件来选择。

    PROCESS FOR THE PREPARATION OF ALOGLIPTIN
    5.
    发明公开
    PROCESS FOR THE PREPARATION OF ALOGLIPTIN 有权
    ALOGLIPTIN制备方法

    公开(公告)号：EP2410855A1

    公开(公告)日：2012-02-01

    申请号：EP10755533.6

    申请日：2010-03-25

    申请人： Mapi Pharma Limited

    发明人： MAROM, Ehud ,  MIZHIRITSKII, Michael ,  RUBNOV, Shai

    IPC分类号： A01N43/54

    CPC分类号： A61K31/513 ,  C07C275/24 ,  C07C275/50 ,  C07D239/545 ,  C07D239/62 ,  C07D403/04

    摘要： The present invention is based on the discovery of a process for preparing pyrimidin- dione compounds, especially alogliptin and its derivatives, which comprises the reaction of a urea derivative of formula (VIII) with a malonic acid or its derivatives to form intermediates of formulae (VII) or (VII-A), which are subsequently converted to a compound of formula (II) upon introduction of a leaving group X. Compound (II) then reacts with an amine to form compound (I), which is optionally converted to its salts of formula (IV).

    摘要翻译： 本发明基于发现嘧啶二酮化合物，特别是阿格列汀及其衍生物的制备方法，该方法包括使式（VIII）的脲衍生物与丙二酸或其衍生物反应，形成式 VII）或（VII-A），随后在引入离去基团X时将其转化成式（II）化合物。然后化合物（II）与胺反应形成化合物（I），其任选转化为 其式（IV）的盐。

    PHENOBARBITAL DERIVATIVES USEFUL IN IMMUNOASSAY
    6.
    发明授权
    PHENOBARBITAL DERIVATIVES USEFUL IN IMMUNOASSAY 有权
    PHENOBARBITALDERIVATE FOR USE IN免疫测试

    公开(公告)号：EP2205571B1

    公开(公告)日：2011-08-31

    申请号：EP08839884.7

    申请日：2008-10-16

    申请人： Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG

    发明人： HUI, Raymond

    IPC分类号： C07D239/62 ,  G01N33/94

    CPC分类号： C07D239/62 ,  Y10T436/13

    摘要： Phenobarbital derivatives synthesized out of the alkyl chain at the 5-position, particularly with hydrophilic properties, and carrying an active ester at the end, allow formation of aminodextran conjugates that give curves in the desired range of the assay in the ONLINE TDM microparticle assay format when matched against the Roche FPIA antibody specific for phenobarbital ('an antibody specific for phenobarbital').