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公开(公告)号：EP2870180A1
公开(公告)日：2015-05-13
申请号：EP13734999.9
申请日：2013-07-04
IPC分类号： C07K16/44
CPC分类号： C07K16/44 , A61K47/6801 , C07K2299/00 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The invention provides anti-biotin antibodies and methods of using the same.
摘要翻译： 本发明提供了抗生物素抗体和使用它们的方法。
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公开(公告)号：EP2170859A1
公开(公告)日：2010-04-07
申请号：EP08759319.0
申请日：2008-06-23
发明人： GEORGES, Guy , HOFFMANN, Eike , KALUZA, Klaus , KOERNER, Matthias , REIFF, Ulrike , WEIGAND, Stefan
IPC分类号： C07D401/04 , C07D401/14 , A61K31/435 , A61P35/00
CPC分类号： C07D401/14 , C07D401/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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公开(公告)号：EP3697441A1
公开(公告)日：2020-08-26
申请号：EP18786786.6
申请日：2018-10-19
发明人： BRINKMANN, Ulrich , DENGL, Stefan , GEORGES, Guy , HOFFMANN, Eike , MAYER, Klaus , BORMANN, Felix
IPC分类号： A61K39/395 , C07K16/46
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公开(公告)号：EP3089759B1
公开(公告)日：2018-12-05
申请号：EP14825155.6
申请日：2014-12-29
发明人： BRINKMANN, Ulrich , HOFFMANN, Eike , DENGL, Stefan , MAYER, Klaus
CPC分类号： C07K16/44 , A61K38/45 , A61K47/557 , A61K47/6817 , A61K47/6829 , A61K47/6835 , A61K47/6879 , A61K47/6893 , C07K16/00 , C07K16/3076 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/94 , C12Y204/02036
摘要： Herein is reported a conjugate of a haptenylated polypeptide toxin and an anti-hapten antibody, wherein a disulfide bond is formed between a cysteine residue either before or after the lysine residue that is used for hapten-conjugation and a cysteine residue in the CDR2 of the antibody, whereby the CDR2 is determined according to Kabat.
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公开(公告)号：EP3138580A1
公开(公告)日：2017-03-08
申请号：EP16189277.3
申请日：2013-07-04
发明人： BRINKMANN, Ulrich , GEORGES, Guy , HOFFMANN, Eike , BENZ, Joerg , HAAS, Alexander , GROTE, Michael , DZIADEK, Sebastian , DENGL, Stefan
IPC分类号： A61K47/68 , C07K16/00 , A61K39/395
CPC分类号： A61K47/48507 , A61K39/385 , A61K47/6835 , A61K47/6879 , A61K47/6897 , A61K2039/6056 , A61K2039/627 , B82Y5/00 , C07K16/00 , C07K16/16 , C07K16/2896 , C07K16/40 , C07K16/44 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/624 , C07K2317/94 , G01N33/6857
摘要： Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.
摘要翻译： 本文报道了包含特异性结合抗原的抗原和抗体的缀合物，其中在抗体的CDR2中的抗原和氨基酸残基之间形成共价键，抗体包含在氨基酸位置53处的半胱氨酸残基（ 根据Kabat）在重链CDR2及其用途。
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公开(公告)号：EP3138578A1
公开(公告)日：2017-03-08
申请号：EP16188547.0
申请日：2013-07-04
发明人： BRINKMANN, Ulrich , GEORGES, Guy , HOFFMANN, Eike
IPC分类号： A61K39/00 , C07K16/44 , A61K31/522
CPC分类号： A61K47/6803 , A61K31/522 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/92
摘要： The invention provides anti-theophylline antibodies and methods of using the same.
摘要翻译： 本发明提供了抗茶碱抗体和使用它们的方法。
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公开(公告)号：EP3959244A1
公开(公告)日：2022-03-02
申请号：EP20722520.2
申请日：2020-04-24
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公开(公告)号：EP3339328A1
公开(公告)日：2018-06-27
申请号：EP18150996.9
申请日：2013-07-04
IPC分类号： C07K16/44
CPC分类号： C07K16/44 , A61K47/48507 , A61K47/6801 , C07K2299/00 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The invention provides anti-biotin antibodies and methods of using the same.
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9.发明公开COVALENTLY LINKED POLYPEPTIDE TOXIN-ANTIBODY CONJUGATES 有权KOVALENTVERKNÜPFTEPOLIPEPTIDTOXIN-ANTIKÖRPERKONGUGATE
公开(公告)号：EP3089759A1
公开(公告)日：2016-11-09
申请号：EP14825155.6
申请日：2014-12-29
发明人： BRINKMANN, Ulrich , HOFFMANN, Eike , DENGL, Stefan , MAYER, Klaus
CPC分类号： C07K16/44 , A61K38/45 , A61K47/557 , A61K47/6817 , A61K47/6829 , A61K47/6835 , A61K47/6879 , A61K47/6893 , C07K16/00 , C07K16/3076 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/94 , C12Y204/02036
摘要： Herein is reported a conjugate of a haptenylated polypeptide toxin and an anti-hapten antibody, wherein a disulfide bond is formed between a cysteine residue either before or after the lysine residue that is used for hapten-conjugation and a cysteine residue in the CDR2 of the antibody, whereby the CDR2 is determined according to Kabat.
摘要翻译： 本文报道了半抗原多肽毒素和抗半抗原抗体的缀合物，其中在用于半抗原缀合的赖氨酸残基之前或之后的半胱氨酸残基之间形成二硫键，并且其中CDR2中的半胱氨酸残基 抗体，由此根据Kabat测定CDR2。
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