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公开(公告)号：EP1519938B1
公开(公告)日：2007-04-11
申请号：EP03740304.5
申请日：2003-06-23
发明人： HAMMARSTROEM, Lars, G., J. , KRAUSS, Nancy, Elisabeth , LABADIE, Sharada, Shenvi , SMITH, David, Bernard , TALAMAS, Francisco, Xavier
IPC分类号： C07D473/00
CPC分类号： C07D473/16 , C07D473/00 , C07D473/34
摘要： The present invention provides a process for producing highly substituted purine compounds from pyrimidine compounds. Furthermore, processes of the present invention allow preparation of a library of purine compounds. Specifically the invention claims a process for the preparation of a substituted purine compound of the formula (I), wherein R1, R2, R3, R4, and R5 are as described herein.
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公开(公告)号：EP1519938A2
公开(公告)日：2005-04-06
申请号：EP03740304.5
申请日：2003-06-23
发明人： HAMMARSTROEM, Lars, G., J. , KRAUSS, Nancy, Elisabeth , LABADIE, Sharada, Shenvi , SMITH, David, Bernard , TALAMAS, Francisco, Xavier
IPC分类号： C07D473/00
CPC分类号： C07D473/16 , C07D473/00 , C07D473/34
摘要： The present invention provides a process for producing highly substituted purine compounds from pyrimidine compounds. Furthermore, processes of the present invention allow preparation of a library of purine compounds. Specifically the invention claims a process for the preparation of a substituted purine compound of the formula (I), wherein R1, R2, R3, R4, and R5 are as described herein.
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公开(公告)号：EP1075467B1
公开(公告)日：2005-03-30
申请号：EP99923484.2
申请日：1999-04-28
发明人： LABADIE, Sharada, Shenvi , ROTSTEIN, David, Mark , SJOGREN, Eric, Brian , TALAMAS, Francisco, Xavier
IPC分类号： C07D231/38 , A61K31/415 , C07D401/10 , C07D403/12 , C07D401/12 , A61K31/44
CPC分类号： C07D231/38 , C07D401/10 , C07D401/12 , C07D403/12
摘要： The present invention relates to certain pyrazole derivatives of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
摘要翻译： 本发明涉及作为p-38MAP激酶抑制剂的式（I）的某些吡唑衍生物，含有它们的药物组合物，它们的使用方法以及制备这些化合物的方法。
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公开(公告)号：EP1075467A1
公开(公告)日：2001-02-14
申请号：EP99923484.2
申请日：1999-04-28
发明人： LABADIE, Sharada, Shenvi , ROTSTEIN, David, Mark , SJOGREN, Eric, Brian , TALAMAS, Francisco, Xavier
IPC分类号： C07D231/38 , A61K31/415 , C07D401/10 , C07D403/12 , C07D401/12 , A61K31/44
CPC分类号： C07D231/38 , C07D401/10 , C07D401/12 , C07D403/12
摘要： The present invention relates to certain pyrazole derivatives of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
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5.发明授权PYRAZOLO[1,5A]PYRIMIDINE AND THIENO[3,2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS 有权作为IRAK4调节剂的吡唑并[1,5A]嘧啶和噻吩并[3,2B]嘧啶衍生物
公开(公告)号：EP2593457B1
公开(公告)日：2017-08-23
申请号：EP11736028.9
申请日：2011-07-08
发明人： ARORA, Nidhi , CHEN, Shaoqing , HERMANN, Johannes, Cornelius , KUGLSTATTER, Andreas , LABADIE, Sharada, Shenvi , LIN, Clara Jeou Jen , LUCAS, Matthew, C. , MOORE, Amy, Geraldine , PAPP, Eva , TALAMAS, Francisco, Xavier , WANNER, Jutta , ZHAI, Yansheng
IPC分类号： C07D487/04 , C07D495/04 , A61K31/4365 , A61K31/519 , A61P11/00 , A61P29/00
CPC分类号： C07D495/04 , C07D487/04
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公开(公告)号：EP1444223A1
公开(公告)日：2004-08-11
申请号：EP02785344.9
申请日：2002-10-31
发明人： HAWLEY, Ronald, Charles , LABADIE, Sharada, Shenvi , SJOGREN, Eric, Brian , TALAMAS, Francisco, Xavier
IPC分类号： C07D403/04 , C07D417/04 , C07D417/14 , C07D409/14 , C07D405/14 , C07D401/14 , C07D403/14 , A61K31/506 , A61P29/00
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to aminopyrimidine and aminopyridine derivatives having the formula (I), wherein V, X, Y, Z, R1, R4, A, B and U have the value given in the specification. The compounds are useful as an inhibitor of IkB kinases and, therefore, may be used for the treatment of inflammatory, metabolic or malignant conditions.
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公开(公告)号：EP1218346A1
公开(公告)日：2002-07-03
申请号：EP00966008.5
申请日：2000-09-14
发明人： GOLDSTEIN, David, Michael , LABADIE, Sharada, Shenvi , ROTSTEIN, David, Mark , SJOGREN, Eric, Brian , TALAMAS, Francisco, Xavier
IPC分类号： C07D231/38 , C07D413/10 , C07D403/10 , C07D401/10 , C07D413/12 , C07D401/12 , C07D409/06 , C07D405/06 , C07D401/06 , C07D405/12 , A61K31/415
CPC分类号： C07D231/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06
摘要： The present invention relates to certain pyrazole derivatives of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
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