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公开(公告)号：EP1218346A1
公开(公告)日：2002-07-03
申请号：EP00966008.5
申请日：2000-09-14
发明人： GOLDSTEIN, David, Michael , LABADIE, Sharada, Shenvi , ROTSTEIN, David, Mark , SJOGREN, Eric, Brian , TALAMAS, Francisco, Xavier
IPC分类号： C07D231/38 , C07D413/10 , C07D403/10 , C07D401/10 , C07D413/12 , C07D401/12 , C07D409/06 , C07D405/06 , C07D401/06 , C07D405/12 , A61K31/415
CPC分类号： C07D231/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06
摘要： The present invention relates to certain pyrazole derivatives of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
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公开(公告)号：EP1423378B1
公开(公告)日：2005-11-09
申请号：EP02767427.4
申请日：2002-08-26
IPC分类号： C07D401/04 , A61K31/4025 , A61P29/00
CPC分类号： C07D401/04
摘要： The present invention provides an aminopyrrole compound of the formula: (I) a prodrug, individual isomer, a mixture of isomers or a pharmaceutically acceptable salt thereof and methods of preparing these compounds and their use in the treatment of diseases, especially inflammatory diseases.
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公开(公告)号：EP1075467B1
公开(公告)日：2005-03-30
申请号：EP99923484.2
申请日：1999-04-28
发明人： LABADIE, Sharada, Shenvi , ROTSTEIN, David, Mark , SJOGREN, Eric, Brian , TALAMAS, Francisco, Xavier
IPC分类号： C07D231/38 , A61K31/415 , C07D401/10 , C07D403/12 , C07D401/12 , A61K31/44
CPC分类号： C07D231/38 , C07D401/10 , C07D401/12 , C07D403/12
摘要： The present invention relates to certain pyrazole derivatives of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
摘要翻译： 本发明涉及作为p-38MAP激酶抑制剂的式（I）的某些吡唑衍生物，含有它们的药物组合物，它们的使用方法以及制备这些化合物的方法。
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公开(公告)号：EP1075467A1
公开(公告)日：2001-02-14
申请号：EP99923484.2
申请日：1999-04-28
发明人： LABADIE, Sharada, Shenvi , ROTSTEIN, David, Mark , SJOGREN, Eric, Brian , TALAMAS, Francisco, Xavier
IPC分类号： C07D231/38 , A61K31/415 , C07D401/10 , C07D403/12 , C07D401/12 , A61K31/44
CPC分类号： C07D231/38 , C07D401/10 , C07D401/12 , C07D403/12
摘要： The present invention relates to certain pyrazole derivatives of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
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公开(公告)号：EP1423378A1
公开(公告)日：2004-06-02
申请号：EP02767427.4
申请日：2002-08-26
IPC分类号： C07D401/04 , A61K31/4025 , A61P29/00
CPC分类号： C07D401/04
摘要： The present invention provides an aminopyrrole compound of the formula: (I) a prodrug, individual isomer, a mixture of isomers or a pharmaceutically acceptable salt thereof and methods of preparing these compounds and their use in the treatment of diseases, especially inflammatory diseases.
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公开(公告)号：EP1324970B1
公开(公告)日：2008-11-05
申请号：EP01969762.2
申请日：2001-09-24
IPC分类号： C07C65/28 , C07C323/56 , C07D231/12 , C07D207/32 , C07D307/38 , C07C65/19 , C07D295/08 , C07D239/38 , C07D249/12 , A61K31/19 , A61K31/33
CPC分类号： C07D207/27 , C07C65/19 , C07C65/28 , C07C229/38 , C07C233/83 , C07C311/13 , C07C317/44 , C07C323/56 , C07C2602/10 , C07D207/327 , C07D211/76 , C07D231/12 , C07D231/14 , C07D233/56 , C07D233/84 , C07D239/26 , C07D239/38 , C07D249/08 , C07D249/12 , C07D257/04 , C07D277/16 , C07D277/30 , C07D277/74 , C07D285/125 , C07D295/155 , C07D307/38 , C07D333/22 , C07D333/24 , C07D333/60
摘要： The current invention provides novel retinoid compounds and methods for their synthesis, the use of such compounds for the preparation of medicaments for treating or preventing emphysema, cancer and dermatological disorders, methods for such deseases and pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders.
摘要翻译： 本发明提供新型类视黄醇化合物及其合成方法，治疗或预防肺气肿，癌症和皮肤疾病的方法以及适用于治疗或预防肺气肿，癌症和皮肤疾病的药物组合物。
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公开(公告)号：EP1324970A2
公开(公告)日：2003-07-09
申请号：EP01969762.2
申请日：2001-09-24
IPC分类号： C07C65/28 , C07C323/56 , C07D231/12 , C07D207/32 , C07D307/38 , C07C65/19 , C07D295/08 , C07D239/38 , C07D249/12 , A61K31/19 , A61K31/33
CPC分类号： C07D207/27 , C07C65/19 , C07C65/28 , C07C229/38 , C07C233/83 , C07C311/13 , C07C317/44 , C07C323/56 , C07C2602/10 , C07D207/327 , C07D211/76 , C07D231/12 , C07D231/14 , C07D233/56 , C07D233/84 , C07D239/26 , C07D239/38 , C07D249/08 , C07D249/12 , C07D257/04 , C07D277/16 , C07D277/30 , C07D277/74 , C07D285/125 , C07D295/155 , C07D307/38 , C07D333/22 , C07D333/24 , C07D333/60
摘要： The current invention provides novel retinoid compounds and methods for their synthesis, the use of such compounds for the preparation of medicaments for treating or preventing emphysema, cancer and dermatological disorders, methods for such deseases and pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders.
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