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1.发明公开AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 有权3- PHENYLDIHYDROPYRIMIDO [4,5-D]的酰胺衍生物的嘧啶酮，生产和使用作为药剂
公开(公告)号：EP1789416A2
公开(公告)日：2007-05-30
申请号：EP05779393.7
申请日：2005-08-30
发明人： ENGH, Richard , HERTENBERGER, Hubert , HONOLD, Konrad , MASJOST, Birgit , RUEGER, Petra , SCHAEFER, Wolfgang , SCHEIBLICH, Stefan , SCHWAIGER, Manfred
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
CPC分类号： C07D487/04
摘要： The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
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2.发明授权AZABENZIMIDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTI-CANCER AGENTS 有权AZABENZIMIDALZOLDERIVATE，制备方法及其用作抗恶性肿瘤药
公开(公告)号：EP1919910B1
公开(公告)日：2011-02-23
申请号：EP06762868.5
申请日：2006-07-28
发明人： ENGH, Richard , HERTENBERGER, Hubert , HONOLD, Konrad , MASJOST, Birgit , RUEGER, Petra , SCHAEFER, Wolfgang , SCHEIBLICH, Stefan , SCHWAIGER, Manfred
IPC分类号： C07D471/04 , A61K31/4353 , A61P35/00
CPC分类号： C07D471/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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公开(公告)号：EP1487819A2
公开(公告)日：2004-12-22
申请号：EP03711955.9
申请日：2003-03-10
IPC分类号： C07D401/12 , A61K31/55 , A61P35/00 , C07D401/14 , C07D405/14 , C07D403/12
CPC分类号： C07D401/12 , C07D223/12 , C07D401/14 , C07D403/12 , C07D405/14
摘要： This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula ( I ) wherein the remaining symbols have the significance given in the specification, as well as processes for their manufacture. The compounds according to this invention possess anti-cell proliferation activity and show an increased plasma-stability.
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4.发明授权AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 有权3- PHENYLDIHYDROPYRIMIDO [4,5-D]的酰胺衍生物的嘧啶酮，生产和使用作为药剂
公开(公告)号：EP1789416B1
公开(公告)日：2009-03-11
申请号：EP05779393.7
申请日：2005-08-30
发明人： ENGH, Richard , HERTENBERGER, Hubert , HONOLD, Konrad , MASJOST, Birgit , RUEGER, Petra , SCHAEFER, Wolfgang , SCHEIBLICH, Stefan , SCHWAIGER, Manfred
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
CPC分类号： C07D487/04
摘要： The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
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5.发明公开AZABENZIMIDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTI-CANCER AGENTS 有权AZABENZIMIDALZOLDERIVATE，制备方法及其用作抗恶性肿瘤药
公开(公告)号：EP1919910A1
公开(公告)日：2008-05-14
申请号：EP06762868.5
申请日：2006-07-28
发明人： ENGH, Richard , HERTENBERGER, Hubert , HONOLD, Konrad , MASJOST, Birgit , RUEGER, Petra , SCHAEFER, Wolfgang , SCHEIBLICH, Stefan , SCHWAIGER, Manfred
IPC分类号： C07D471/04 , A61K31/4353 , A61P35/00
CPC分类号： C07D471/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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