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公开(公告)号：EP2814587B1
公开(公告)日：2018-05-02
申请号：EP13704599.3
申请日：2013-02-14
CPC分类号： C07K1/22 , B01D15/168 , B01D15/3809 , B01J20/289 , B01J20/3204 , B01J20/3206 , B01J20/3219 , B01J20/3274 , B01J39/26 , C07K16/065 , C07K16/2866 , G01N33/6854
摘要： Herein is reported the use of an immobilized non-covalent complex of a neonatal Fc receptor (FcRn) and beta-2-microglobulin (b2m) as affinity chromatography ligand in general and, for example, for the determination of the in vivo half-live of an antibody by determining the ratio of the retention times of the antibody and a reference antibody.
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2.发明公开
公开(公告)号：EP3728327A1
公开(公告)日：2020-10-28
申请号：EP18829371.6
申请日：2018-12-20
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3.发明授权AZABENZIMIDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTI-CANCER AGENTS 有权AZABENZIMIDALZOLDERIVATE，制备方法及其用作抗恶性肿瘤药
公开(公告)号：EP1919910B1
公开(公告)日：2011-02-23
申请号：EP06762868.5
申请日：2006-07-28
发明人： ENGH, Richard , HERTENBERGER, Hubert , HONOLD, Konrad , MASJOST, Birgit , RUEGER, Petra , SCHAEFER, Wolfgang , SCHEIBLICH, Stefan , SCHWAIGER, Manfred
IPC分类号： C07D471/04 , A61K31/4353 , A61P35/00
CPC分类号： C07D471/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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4.发明授权AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 有权3- PHENYLDIHYDROPYRIMIDO [4,5-D]的酰胺衍生物的嘧啶酮，生产和使用作为药剂
公开(公告)号：EP1789416B1
公开(公告)日：2009-03-11
申请号：EP05779393.7
申请日：2005-08-30
发明人： ENGH, Richard , HERTENBERGER, Hubert , HONOLD, Konrad , MASJOST, Birgit , RUEGER, Petra , SCHAEFER, Wolfgang , SCHEIBLICH, Stefan , SCHWAIGER, Manfred
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
CPC分类号： C07D487/04
摘要： The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
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5.发明公开AZABENZIMIDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTI-CANCER AGENTS 有权AZABENZIMIDALZOLDERIVATE，制备方法及其用作抗恶性肿瘤药
公开(公告)号：EP1919910A1
公开(公告)日：2008-05-14
申请号：EP06762868.5
申请日：2006-07-28
发明人： ENGH, Richard , HERTENBERGER, Hubert , HONOLD, Konrad , MASJOST, Birgit , RUEGER, Petra , SCHAEFER, Wolfgang , SCHEIBLICH, Stefan , SCHWAIGER, Manfred
IPC分类号： C07D471/04 , A61K31/4353 , A61P35/00
CPC分类号： C07D471/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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6.发明公开AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 有权3- PHENYLDIHYDROPYRIMIDO [4,5-D]的酰胺衍生物的嘧啶酮，生产和使用作为药剂
公开(公告)号：EP1789416A2
公开(公告)日：2007-05-30
申请号：EP05779393.7
申请日：2005-08-30
发明人： ENGH, Richard , HERTENBERGER, Hubert , HONOLD, Konrad , MASJOST, Birgit , RUEGER, Petra , SCHAEFER, Wolfgang , SCHEIBLICH, Stefan , SCHWAIGER, Manfred
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
CPC分类号： C07D487/04
摘要： The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
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