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    ALKALINE PRETREATMENT OF PARVOVIRUSES FOR IMMUNOASSAYS
    2.
    发明公开
    ALKALINE PRETREATMENT OF PARVOVIRUSES FOR IMMUNOASSAYS 审中-公开
    ALKALISCHE VORBEHANDLUNG VON PARVOVIRENFÜRIMMUNOASSAYS

    公开(公告)号：EP3130922A1

    公开(公告)日：2017-02-15

    申请号：EP15180536.3

    申请日：2015-08-11

    申请人： Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG

    发明人： FAATZ, Elke ,  MÜNCH, Peter ,  RITTER, Mirko ,  TABARES, Gloria

    IPC分类号： G01N33/569

    CPC分类号： G01N33/56983 ,  G01N33/54393 ,  G01N2333/015

    摘要： The present invention relates to a method for detecting a capsid polypeptide of a non-enveloped virus in a sample from a subject comprising (a) contacting said sample with a base, and (b) detecting a capsid polypeptide of said virus in said sample. Moreover, the present invention relates to a method for pre-processing a sample from a subject for detection of a virus, comprising contacting said sample with a base. Moreover, the present invention relates to kits, uses and devices related to said methods.

    摘要翻译： 本发明涉及一种检测来自受试者的样品中非包膜病毒的衣壳多肽的方法，包括（a）使所述样品与碱接触，和（b）在所述样品中检测所述病毒的衣壳多肽。 此外，本发明涉及一种用于预处理来自受试者的用于检测病毒的样品的方法，包括使所述样品与碱接触。 此外，本发明涉及与所述方法相关的试剂盒，用途和装置。

    ANTIBODIES BINDING TO HUMAN AND CYNOMOLGUS CD3 EPSILON
    3.
    发明公开
    ANTIBODIES BINDING TO HUMAN AND CYNOMOLGUS CD3 EPSILON 审中-公开
    抗生素MIT BINDUNG人类 - CYCOMOLGUS-CD3-EPSILON

    公开(公告)号：EP3149041A1

    公开(公告)日：2017-04-05

    申请号：EP15725002.8

    申请日：2015-05-22

    申请人： F. Hoffmann-La Roche AG

    发明人： TIEFENTHALER, Georg ,  MOESSNER, Ekkehard ,  LIFKE, Valeria ,  PLATZER, Josef ,  OFFNER, Sonja ,  JAEGER, Christiane ,  RITTER, Mirko

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2809 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/75 ,  C07K2317/92

    摘要： One aspect as reported herein is using a method comprising the step of immunizing an experimental animal, three times with primary cynomolgus PBLs, whereby the PBLs are optionally enriched for T cells without using primary human PBLs as immunogen and without using a denaturing agent for producing a human cynomolgus cross-reactive antibody specifically binding to human CD3 epsilon of SEQ ID NO: 02 and specifically binding to a polypeptide of SEQ ID NO: 01, wherein the human cynomolgus cross-reactive antibody specifically binds to human and cynomolgus T cells, activates human T cells and does not bind to the same epitope as the antibody OKT3, the antibody UCHT1 and/or antibody the SP34.

    摘要翻译： 本文报道的一个方面是使用包括免疫实验动物的步骤的方法，三次用初级食蟹猴PBL，其中PBL可任选地富含T细胞，而不使用原代人PBL作为免疫原，并且不使用变性剂来生产 与SEQ ID NO：02的人CD3ε特异性结合并特异性结合SEQ ID NO：01的多肽的人食蟹猴交叉反应性抗体，其中所述人食蟹猴交叉反应性抗体特异性结合人和食蟹猴T细胞，激活人 T细胞，并且不结合与抗体OKT3，抗体UCHT1和/或抗体SP34相同的表位。

    ANTIBODIES BINDING TO HUMAN AND CYNOMOLGUS CD3 EPSILON
    5.
    发明公开
    ANTIBODIES BINDING TO HUMAN AND CYNOMOLGUS CD3 EPSILON 审中-公开

    公开(公告)号：EP3763739A1

    公开(公告)日：2021-01-13

    申请号：EP20163877.2

    申请日：2015-05-22

    申请人： F. Hoffmann-La Roche AG

    发明人： NEUMANN, Christiane ,  LIFKE, Valeria ,  MOESSNER, Ekkehard ,  OFFNER, Sonja ,  PLATZER, Josef ,  TIEFENTHALER, Georg ,  RITTER, Mirko

    IPC分类号： C07K16/28

    摘要： One aspect as reported herein is using a method comprising the step of immunizing an experimental animal, three times with primary cynomolgus PBLs, whereby the PBLs are optionally enriched for T cells without using primary human PBLs as immunogen and without using a denaturing agent for producing a human cynomolgus cross-reactive antibody specifically binding to human CD3 epsilon of SEQ ID NO: 02 and specifically binding to a polypeptide of SEQ ID NO: 01, wherein the human cynomolgus cross-reactive antibody specifically binds to human and cynomolgus T cells, activates human T cells and does not bind to the same epitope as the antibody OKT3, the antibody UCHT1 and/or antibody the SP34.