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公开(公告)号：EP4051674A1
公开(公告)日：2022-09-07
申请号：EP20797473.4
申请日：2020-10-28
发明人： DUPLESSIS, Martin , GAUFRETEAU, Delphine , HUTTER, Roman , JOVCHEVA, Eleonora , KUHN, Bernd , LAZARSKI, Kiel , LIANG, Yanke , LUEBBERS, Thomas , MARTIN, Laetitia, Janine , MARTIN, Rainer, E. , MUELLER, Barbara, Johanna , NORCROSS, Roger , SCHMID, Philipp , WACH, Jean-Yves
IPC分类号： C07D401/14 , C07D471/08 , C07D487/08 , C07D487/10 , C07D498/10 , C07D519/00 , A61P35/00 , A61K31/501 , A61K31/537
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公开(公告)号：EP4054724A1
公开(公告)日：2022-09-14
申请号：EP20880820.4
申请日：2020-10-26
发明人： GAUFRETEAU, Delphine , HUTTER, Roman , JOVCHEVA, Eleonora , KUHN, Bernd , LUEBBERS, Thomas , MARTIN, Rainer, E. , MARTIN, Laetitia, Janine , MUELLER, Barbara, Johanna , NORCROSS, Roger , RICKLIN, Fabienne , SCHMID, Philipp , WACH, Jean-yves , WICHMANN, Juergen , DUPLESSIS, Martin , LAZARSKI, Kiel , LIANG, Yanke
IPC分类号： A61P35/00 , C07D487/04
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公开(公告)号：EP4208456A1
公开(公告)日：2023-07-12
申请号：EP21772763.5
申请日：2021-09-01
发明人： BENZ, Joerg , GRETHER, Uwe , HORNSPERGER, Benoit , KROLL, Carsten , KUHN, Bernd , MARTIN, Rainer, E. , O'HARA, Fionn , PUELLMANN, Bernd , RICHTER, Hans , RITTER, Martin
IPC分类号： C07D403/06 , C07D403/14 , C07D413/04 , C07D413/14 , C07D487/04 , A61K31/4192 , A61K31/422 , A61P25/00
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公开(公告)号：EP2225221A2
公开(公告)日：2010-09-08
申请号：EP08865563.4
申请日：2008-12-12
发明人： BENSON, Gregory Martin , BLEICHER, Konrad , GRETHER, Uwe , KUHN, Bernd , MARTIN, Rainer, E. , PLANCHER, Jean-Marc , RICHTER, Hans , TAYLOR, Sven , YANG, Minmin
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D235/12 , C07D401/12 , C07D401/14
摘要： This invention relates to novel carboxyl- or hydroxylsubstituted benzimidazole derivatives of formula (I) wherein R
1 to R
6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.
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