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公开(公告)号：EP4034538A1
公开(公告)日：2022-08-03
申请号：EP20780981.5
申请日：2020-09-22
发明人： GOBBI, Luca , GRETHER, Uwe , GROEBKE ZBINDEN, Katrin , HORNSPERGER, Benoit , KROLL, Carsten , KUHN, Bernd , LUTZ, Marius Daniel Rinaldo , O'HARA, Fionn , RICHTER, Hans , RITTER, Martin
IPC分类号： C07D491/04 , A61P25/00 , A61P35/00 , A61P37/00 , A61K31/5375
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公开(公告)号：EP4028402A1
公开(公告)日：2022-07-20
申请号：EP20774900.3
申请日：2020-09-10
发明人： COLLIN, Ludovic , EDELMANN, Martin , GOBBI, Luca , GRETHER, Uwe , HARTUNG, Thomas , HE, Yingfang , HONER, Michael , HORNSPERGER, Benoit , KROLL, Carsten , MU, Linjing , MURI, Dieter , O'HARA, Fionn , RICHTER, Hans , RITTER, Martin
IPC分类号： C07D498/04 , C07B59/00 , A61P25/16 , A61P25/28 , A61P35/00 , A61K31/5365
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公开(公告)号：EP3694840A1
公开(公告)日：2020-08-19
申请号：EP18780151.9
申请日：2018-10-09
发明人： BENZ, Joerg , GRETHER, Uwe , HORNSPERGER, Benoit , KUHN, Bernd , RICHTER, Hans , KOCER, Buelent , O'HARA, Fionn , RITTER, Martin , TSUCHIYA, Satoshi , COLLIN, Ludovic , JOHNSON, Simon E. , BELL, Charles
IPC分类号： C07D239/95 , C07D403/12 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/04 , A61P25/00 , A61K31/515
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4.发明公开BENZOFURAN- AND BENZO[B]THIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AND USE THEREOF AS HISTAMINE 3 RECEPTOR MODULATORS 审中-公开苯并呋喃和苯并[b]噻吩-2-甲酰胺及其作为组胺-3受体的调节剂
公开(公告)号：EP2183237A1
公开(公告)日：2010-05-12
申请号：EP08775114.5
申请日：2008-07-16
发明人： MOHR, Peter , NETTEKOVEN, Matthias , PLANCHER, Jean-Marc , RICHTER, Hans , ROCHE, Olivier , TAKAHASHI, Tadakatsu , TAYLOR, Sven
IPC分类号： C07D307/85 , C07D333/70 , C07D409/06 , C07D413/06 , C07D417/06 , A61K31/496 , A61P3/04
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formula (I) wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP2118089A1
公开(公告)日：2009-11-18
申请号：EP08708315.0
申请日：2008-01-29
IPC分类号： C07D401/12 , C07D401/14 , C07D451/06 , A61K31/454 , A61P3/04
CPC分类号： C07D401/12 , C07D401/02 , C07D401/14 , C07D451/06
摘要： The present invention relates to compounds of formula (I), wherein A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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6.发明公开5 -AMIDO- (IH- INDOL- 2 -YL) PIPERAZIN-1-YL-METHANONE DERIVATIVES AS HISTAMINE H3 RECEPTOR LIGANDS 审中-公开5-AMID-（1H-吲哚-2-基） - 哌嗪-1-基 - 甲胺衍生物，组氨酸 - H3-REZEPTORLIGANDEN
公开(公告)号：EP2118059A1
公开(公告)日：2009-11-18
申请号：EP08708319.2
申请日：2008-01-29
IPC分类号： C07D209/42 , C07D401/04 , C07D403/06 , A61K31/404 , A61P3/04 , A61P3/10
CPC分类号： C07D209/42 , C07D401/04 , C07D403/06
摘要： The present invention relates to compounds of formula (I): wherein A, G and R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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7.发明公开INDOLE DERIVATIVES AND THEIR USE AS 5-HT2B AND 5-HT2C RECEPTOR LIGANDS 有权吲哚衍生物及其作为5-HT 2B及5-HT 2C受体配体的用途
公开(公告)号：EP1347979A1
公开(公告)日：2003-10-01
申请号：EP01989597.8
申请日：2001-12-14
发明人： BENTLEY, Jonathan Mark, Oakdene Court , BICKERDIKE, Michael John, Oakdene Court , HEBEISEN, Paul , KENNETT, Guy Anthony, Oakdene Court , LIGHTOWLER, Sean, Oakdene Court , MATTEI, Patrizio , MIZRAHI, Jacques , MORLEY, Timothy James, Oakdene Court , PLANCHER, Jean-Marc , RICHTER, Hans , ROEVER, Stephan , TAYLOR, Sven , VICKERS, Steven Paul, Oakdene Court
IPC分类号： C07D487/04 , A61K31/40 , A61P43/00
CPC分类号： C07D487/04
摘要： The present invention refers to chemical compounds of formula (I), as well as pharmaceutically usable salts, solvates and esters thereof, wherein R1 to R4 and n have the significance given in claim (1). They can be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes, obesity and sleep apnoea.
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公开(公告)号：EP1325008A1
公开(公告)日：2003-07-09
申请号：EP01962869.2
申请日：2001-07-24
发明人： BENTLEY, Jonathan, Mark , HEBEISEN, Paul , MULLER, Marc , RICHTER, Hans , ROEVER, Stephan , MATTEI, Patrizio , TAYLOR, Sven
IPC分类号： C07D487/04 , A61K31/4985 , A61P3/10
CPC分类号： C07D487/04
摘要： The present invention refers to chemical compounds of formula (I) as well as pharmaceutically usable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1. They can be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnoea.
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9.发明公开DERIVATIVES OF 3-PYRROLIDYLIDENE-2-ONE-CEPHALOSPORINES 失效3- PYRROLIDYLIDEN-2-ON-CEPHALOSPORINDERIVATEN
公开(公告)号：EP0812323A1
公开(公告)日：1997-12-17
申请号：EP96904802.0
申请日：1996-02-16
CPC分类号： C07D501/00 , Y02P20/55
摘要： Cephalosporin derivatives of general formula (I) wherein R1 is hydrogen, lower alkyl, aralkyl, cycloalkyl, R3CO- or -C(R4R5)CO2R6; where R?4 and R5¿ are each independently hydrogen or lower alkyl, or R?4 and R5¿ taken together form a cycloalkyl group; R3 is hydrogen or lower alkyl and R6 is hydrogen, lower alkyl, lower alkenyl or a carboxylic acid protecting group. R2 is isobutyl, 2,2-dimethyl-propyl or cyclohexyl-methyl; n is 0, 1 or 2; X is CH or N; as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula (I) and of their esters and salts.
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公开(公告)号：EP4326714A1
公开(公告)日：2024-02-28
申请号：EP22724696.4
申请日：2022-04-22
发明人： AMOUSSA, Machoud , BENZ, Joerg , BRIAN, Niels Kevin , FRISTON, Kallie , GIROUD, Maude , GRETHER, Uwe , GROEBKE ZBINDEN, Katrin , HORNSPERGER, Benoit , KROLL, Carsten , KUHN, Bernd , LEAKE, Camiel John , MARTIN, Rainer E. , NIPPA, David Friedrich Erhard , O'HARA, Fionn Susannah , PUELLMANN, Bernd , RICHTER, Hans , RITTER, Martin , ROMBACH, Didier , SCHMID, Philipp Claudio , ZHANG, Shounan
IPC分类号： C07D403/14 , C07D407/14 , C07D413/14 , A61K31/4196 , A61K31/4245 , A61P35/00
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