公开(公告)号：EP4352675A1

公开(公告)日：2024-04-17

申请号：EP22731709.6

申请日：2022-06-08

申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

发明人： HEINEMEYER, Thomas ,  KEMPKEN, Dieter ,  ROETZER, Marian ,  SCHEINPFLUG, Lorenz ,  SCHWEINBERGER, Florian

IPC分类号： G06Q10/08 ,  G16H40/63 ,  G04F8/00 ,  G04G17/00

CPC分类号： G16H40/63 ,  G06Q10/0637 ,  G04F1/005

公开(公告)号：EP3840014A1

公开(公告)日：2021-06-23

申请号：EP19217080.1

申请日：2019-12-17

申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

发明人： QUINT, Stefan ,  ROETZER, Marian ,  SCHWEINBERGER, Florian ,  TIEMANN, Benjamin ,  WAGNER, Marius ,  ZIMMERMAN, Ralf

IPC分类号： H01J49/00 ,  G01N30/72

摘要： An analytical system (100) comprising a mass spectrometer (MS) (40) coupled to liquid chromatography (LC) (20) via an ionization source (IS) (30) and an automated method of maintaining the analytical system (100) in a QC-compliant status are described. The method comprises determining a deviation of the analytical system (100) from a QC-compliant status by determining a deviation of one or more predetermined parameters (1, 2) in an m/z spectrum (11) above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure (12) upon determining a deviation from the QC-compliant status, determining (13) a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure (12) by determining a return or a failed return respectively of the one or more predetermined parameters (1, 2) in an m/z spectrum (14, 16) below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure (15) upon determining a failed return to the QC-compliant status.