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公开(公告)号：EP2534132A1
公开(公告)日：2012-12-19
申请号：EP11702449.7
申请日：2011-02-04
发明人： BARTKOVITZ, David Joseph , CHU, Xin-Jie , DING, Qingjie , JIANG, Nan , LIU, Jin-Jun , ROSS, Tina Morgan , ZHANG, Jing , ZHANG, Zhuming
IPC分类号： C07D207/10 , A61K31/40 , A61P35/00
CPC分类号： C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12
摘要： There are provided compounds of the formula (I) wherein X, Y, R
1 , R
2 , R
3 , R
3 , R
4 , R
5 , R
6 and R
7 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.-
公开(公告)号：EP1996591A1
公开(公告)日：2008-12-03
申请号：EP07726742.5
申请日：2007-03-09
发明人： DING, Qingjie , LIU, Jin-Jun , ZHANG, Zhuming
IPC分类号： C07D471/10 , C07D471/20 , A61P35/04
CPC分类号： C07D471/10 , C07D471/20
摘要： There are provided spiroindolinones of the formula (I), (II) or (III) and enantiomers and pharmaceutically acceptable salts and esters thereof which have utility as antiproliferative agents, especially, as anticancer agents.
摘要翻译： 提供了式（I），（II）或（III）的螺吲哚酮及其对映体和药学上可接受的盐和酯，其可用作抗增殖剂，特别是作为抗癌剂。
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公开(公告)号：EP2536731A1
公开(公告)日：2012-12-26
申请号：EP11703869.5
申请日：2011-02-14
发明人： LIU, Jin-Jun , ZHANG, Jing , ZHANG, Zhuming
IPC分类号： C07D487/10 , A61K31/407 , A61P35/00
CPC分类号： C07D487/10
摘要： There is provided a compound of the Formula (I) wherein X, Y, W, R
1 , R
2 and R
3 are as described herein. The compounds have activity as anticancer agents.摘要翻译： 提供了式（I）的化合物，其中X，Y，W，R 1，R 2和R 3如本文所述。 该化合物具有抗癌剂的活性。
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4.发明公开PYRAZOLOPYRIMIDONE AND PYRAZOLOPYRIDONE INHIBITORS OF TANKYRASE 审中-公开端锚聚合酶PYRAZOLOPYRIMIDON-和pyrazolopyridone抑制剂
公开(公告)号：EP2858994A1
公开(公告)日：2015-04-15
申请号：EP13726537.7
申请日：2013-06-04
发明人： FENG, Jianwen , HAYNES, Nancy-Ellen , HERMANN, Johannes Cornelius , KIM, Kyungjin , LIU, Jin-Jun , SCOTT, Nathan Robert , YI, Lin , ZAK, Mark , ZHAO, Guiling
IPC分类号： C07D487/04 , A61K31/437 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04
摘要： There are provided compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein Q, R
1 and R
2 are as defined herein. The compounds of formula I are useful in the treatment of cancer.-
5.发明公开NOVEL N-SUBSTITUTED-PYRROLIDINES AS INHIBITORS OF MDM2-P-53 INTERACTIONS 审中-公开新的N-取代的吡咯烷AS MDM2 P-53相互作用抑制剂
公开(公告)号：EP2488491A1
公开(公告)日：2012-08-22
申请号：EP10768450.8
申请日：2010-10-11
IPC分类号： C07D207/16 , C07D401/06 , C07D401/12 , C07D403/12 , A61K31/402 , A61K31/4025 , A61P35/00
CPC分类号： C07D207/16 , C07D401/06 , C07D401/12 , C07D403/12
摘要： There are provided compounds of the formula (I) wherein X, Y, R
1 , R
2 , R
3 , R
3 , R
4 , and R
5 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof which are useful as anticancer agents.-
公开(公告)号：EP1996591B1
公开(公告)日：2011-01-12
申请号：EP07726742.5
申请日：2007-03-09
发明人： DING, Qingjie , LIU, Jin-Jun , ZHANG, Zhuming
IPC分类号： C07D471/10 , C07D471/20 , A61P35/04
CPC分类号： C07D471/10 , C07D471/20
摘要： There are provided spiroindolinones of the formula (I), (II) or (III) and enantiomers and pharmaceutically acceptable salts and esters thereof which have utility as antiproliferative agents, especially, as anticancer agents.
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公开(公告)号：EP1615928A1
公开(公告)日：2006-01-18
申请号：EP04725039.4
申请日：2004-04-01
发明人： CHEN, Yi , DERMATAKIS, Apostolos , LIU, Jin-Jun , LUK, Kin-Chun , MICHOUD, Christophe , ROSSMAN, Pamela, Loreen
IPC分类号： C07D487/04 , C07D239/46 , C07D239/42 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： Disclosed are novel pyrimido compounds of the formula (I) that are selective inhibitors of both KDR and FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and the use for treating cancer.
摘要翻译： 公开了式（I）的新型嘧啶化合物，其是KDR和FGFR激酶的选择性抑制剂。 这些化合物及其药学上可接受的盐是用于治疗或控制实体瘤，特别是乳腺癌，结肠癌，肺癌和前列腺肿瘤的抗增殖剂。 还公开了含有这些化合物的药物组合物以及用于治疗癌症的用途。
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公开(公告)号：EP2854800A1
公开(公告)日：2015-04-08
申请号：EP13725648.3
申请日：2013-05-27
发明人： BARTKOVITZ, David Joseph , CHU, Xin-Jie , EHRLICH, George , LIU, Jin-Jun , MICHEL, Hanspeter , VU, Binh Thanh , ZHAO, Chunlin
IPC分类号： A61K31/40 , C07D401/06 , C07D409/04 , C07D207/16
CPC分类号： C07D207/16 , C07D401/12 , C07D405/12 , C07D471/04 , C07F9/5725 , C07H17/02
摘要： There are provided compounds of the formula wherein X, Y, Z, R1, R2 and R3 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
摘要翻译： 提供下式的化合物其中X，Y，Z，R 1，R 2和R 3如本文所述，其对映异构体及其药学上可接受的盐和酯。 该化合物可用作抗癌剂。
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公开(公告)号：EP2501691A1
公开(公告)日：2012-09-26
申请号：EP10779009.9
申请日：2010-11-15
发明人： DING, Qingjie , JIANG, Nan , LIU, Jin-Jun , ZHANG, Jing , ZHANG, Zhuming
IPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , A61K31/4025 , A61K31/4439 , A61P35/00
CPC分类号： C07D403/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/04 , C07D409/14
摘要： The present invention relates to pyrrolidine-2-carboxamide derivatives of formula (I), wherein R
1 , R
2 , R
3 , R
3 , R
4 , R
5 are as described herein and which act as antagonists of mdm2 interactions and hence are useful as potent and selective anticancer agents.摘要翻译： 本发明涉及式（I）的吡咯烷-2-甲酰胺衍生物，其中R 1，R 2，R 3，R 3，R 4，R 5如本文所述并且作为mdm 2相互作用的拮抗剂，因此是 可用作有效和选择性的抗癌剂。
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10.发明公开
公开(公告)号：EP1805174A1
公开(公告)日：2007-07-11
申请号：EP05791894.8
申请日：2005-10-05
发明人： LIU, Jin-Jun
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to 1,5-Naphthyridine azolidinones of the formula (I) to processes for the manufacture of said compounds, as well as medicaments containing them. These compounds are inhibitors of CDK1 and show anti prol if erative activity. They are therefore useful as anti-cancer agents.
摘要翻译： 本发明涉及式（I）的1,5-萘啶吡咯烷酮，用于制备所述化合物的方法以及包含它们的药物。 这些化合物是CDK1的抑制剂并显示出抗增殖活性。 因此它们可用作抗癌剂。
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