公开(公告)号：EP1794172A1

公开(公告)日：2007-06-13

申请号：EP05777388.9

申请日：2005-08-16

申请人： F.HOFFMANN-LA ROCHE AG

发明人： MARTIN, Joseph, Armstrong ,  SARMA, Keshab ,  SMITH, David, Bernard

IPC分类号： C07H19/067 ,  A61P31/14 ,  A61K31/7068

CPC分类号： C07H19/06 ,  C07H19/067 ,  C07H19/12

摘要： 4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-diyhdroxy-5-hydroxymethyl-tetrahydrofuran-2-yl)-1H-pyrimidin-2-one (I:R1=R2=R3=R4=H) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process. (I)

摘要翻译： 4-氨基-1 - （（2R，3S，4S，5R）-5-叠氮基-3,4-二羟基-5-羟甲基 - 四氢呋喃-2-基）-1H-嘧啶-2-酮（I： R2 = R3 = R4 = H）以及它们的前药是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制HCV和治疗HCV介导的疾病的组合物和方法，用于制备在该方法中使用的化合物和合成中间体的方法。 （一世）

公开(公告)号：EP1794172B1

公开(公告)日：2009-07-15

申请号：EP05777388.9

申请日：2005-08-16

申请人： F.HOFFMANN-LA ROCHE AG

发明人： MARTIN, Joseph, Armstrong ,  SARMA, Keshab ,  SMITH, David, Bernard

IPC分类号： C07H19/067 ,  A61P31/14 ,  A61K31/7068

CPC分类号： C07H19/06 ,  C07H19/067 ,  C07H19/12

摘要： 4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-diyhdroxy-5-hydroxymethyl-tetrahydrofuran-2-yl)-1H-pyrimidin-2-one (I:R1=R2=R3=R4=H) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process. (I)