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1.发明公开BISPECIFIC HER2 ANTIBODIES AND METHODS OF USE 有权BISPEZIFISCHE HER2-ANTIKÖRPERUND VERFAHREN ZUR VERWENDUNG
公开(公告)号：EP3083696A1
公开(公告)日：2016-10-26
申请号：EP14821603.9
申请日：2014-12-18
发明人： CROASDALE, Rebecca , DUERNER, Lydia Jasmin , GEORGES, Guy , HOFER, Thomas , HOSSE, Ralf , KLEIN, Christian , MOESSNER, Ekkehard , MOSER, Samuel , SCHAEFER, Wolfgang , SCHANZER, Juergen Michael , SCHEUER, Werner , SUSTMANN, Claudio , UMANA, Pablo
IPC分类号： C07K16/32
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific HER2 antibodies, novel HER2 antibody variants, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及双特异性HER2抗体，新型HER2抗体变体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：EP2451479B1
公开(公告)日：2015-04-01
申请号：EP10727425.0
申请日：2010-06-30
发明人： BRAMLAGE, Birgit , BRINKMANN, Ulrich , CROASDALE, Rebecca , DILL, Simone , DORMEYER, Wilma , GEORGES, Guy , GROTE, Michael , HAAS, Alexander , HOFFMANN, Eike , ICKENSTEIN, Ludger Markus , JAHN-HOFMANN, Kerstin , JOHN, Matthias , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
IPC分类号： A61K31/704 , A61K39/00 , A61K39/395 , A61K47/48 , B82Y5/00 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C07K16/46 , C12N15/11 , C12N15/113
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
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公开(公告)号：EP2435473B1
公开(公告)日：2013-10-02
申请号：EP10721130.2
申请日：2010-05-25
IPC分类号： C07K16/00 , C07K16/46 , C07K16/22 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2863 , C07K16/22 , C07K2317/31 , C07K2317/35 , C07K2317/526 , C07K2317/64 , C07K2317/66 , C07K2317/92
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公开(公告)号：EP2435473A1
公开(公告)日：2012-04-04
申请号：EP10721130.2
申请日：2010-05-25
IPC分类号： C07K16/00 , C07K16/46 , C07K16/22 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2863 , C07K16/22 , C07K2317/31 , C07K2317/35 , C07K2317/526 , C07K2317/64 , C07K2317/66 , C07K2317/92
摘要： The present invention relates to tri- or tetraspecific antibodies, their manufacture and use.
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5.发明授权A COMPLEX OF BI-SPECIFIC ANTIBODY AND DIGOXIGENIN CONJUGATED TO A THERAPEUTIC OR DIAGNOSTIC AGENT 有权TO治疗或诊断COMPLEX由共轭双特异性抗体和地高辛
公开(公告)号：EP2451480B1
公开(公告)日：2015-08-19
申请号：EP10734909.4
申请日：2010-07-05
发明人： BRINKMANN, Ulrich , CROASDALE, Rebecca , LAU, Wilma , GEORGES, Guy , HAAS, Alexander , HOFFMANN, Eike , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
IPC分类号： A61K31/704 , A61K39/00 , A61K39/395 , A61K47/48 , B82Y5/00 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C07K16/46 , C12N15/11 , C12N15/113
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
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6.发明公开A COMPLEX OF BI-SPECIFIC ANTIBODY AND DIGOXIGENIN CONJUGATED TO A THERAPEUTIC OR DIAGNOSTIC AGENT 有权A EIN治疗药物诊断剂KONJUGIERTER KOMPLEX AUS BISPEZIFISCHEM抗生素DIGOXIGENIN
公开(公告)号：EP2451480A1
公开(公告)日：2012-05-16
申请号：EP10734909.4
申请日：2010-07-05
发明人： BRINKMANN, Ulrich , CROASDALE, Rebecca , LAU, Wilma , GEORGES, Guy , HAAS, Alexander , HOFFMANN, Eike , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
IPC分类号： A61K39/395 , A61K47/48 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C07K16/46 , C12N15/113
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及与地高辛特异性结合的抗体，其制备方法，它们作为治疗或诊断剂的递送平台的用途，含有所述抗体的药物组合物及其用途。
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公开(公告)号：EP2451479A1
公开(公告)日：2012-05-16
申请号：EP10727425.0
申请日：2010-06-30
发明人： BRAMLAGE, Birgit , BRINKMANN, Ulrich , CROASDALE, Rebecca , DILL, Simone , DORMEYER, Wilma , GEORGES, Guy , GROTE, Michael , HAAS, Alexander , HOFFMANN, Eike , ICKENSTEIN, Ludger Markus , JAHN-HOFMANN, Kerstin , JOHN, Matthias , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
IPC分类号： A61K39/395 , A61K47/48 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C07K16/46 , C12N15/113
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical 5 compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及与地高辛特异性结合的抗体，其制备方法，它们作为治疗或诊断剂的递送平台的用途，含有所述抗体的药物组合物及其用途。
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