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1.发明公开DETECTION OF A POSTTRANSLATIONALLY MODIFIED POLYPEPTIDE BY A BI-VALENT BINDING AGENT 有权翻译后修饰的多肽的由二价结合分子检测
公开(公告)号：EP2659269A1
公开(公告)日：2013-11-06
申请号：EP11808627.1
申请日：2011-12-21
发明人： GERG, Michael , HEINDL, Dieter , KLEIN, Christian , MERTENS, Alfred , SCHMID, Volker , SCHRAEML, Michael , SOUKUPOVA, Monika , TACKE, Michael
IPC分类号： G01N33/50 , G01N33/531
CPC分类号： C07K16/468 , G01N33/531
摘要： A bi-valent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bi-valent binding agent, and for use of the disclosed bi-valent binding agent in histological staining procedures.
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公开(公告)号：EP2534480A1
公开(公告)日：2012-12-19
申请号：EP11702212.9
申请日：2011-02-04
IPC分类号： G01N33/50
CPC分类号： G01N33/5014 , G01N33/5044 , G01N33/5047
摘要： Herein is reported a cell analytical technology based on a three-dimensional spheroid/aggregate co-culture assay, wherein the spheroid or aggregate is formed of tumor and natural killer cells. This method is useful for the in vitro functional analysis of antibodies in single and high-throughput format.
摘要翻译： 本文报道基于三维球状体/聚集体的共培养测定法，其中，所述球状体或聚集体肿瘤和天然杀伤细胞的形成的细胞分析技术。 该方法对于单一和高通量形式的抗体的体外功能分析是有用的。
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3.发明授权DETECTION OF A POSTTRANSLATIONALLY MODIFIED POLYPEPTIDE BY A BI-VALENT BINDING AGENT 有权翻译后修饰的多肽的由二价结合分子检测
公开(公告)号：EP2659269B1
公开(公告)日：2016-10-26
申请号：EP11808627.1
申请日：2011-12-21
发明人： GERG, Michael , HEINDL, Dieter , KLEIN, Christian , MERTENS, Alfred , SCHMID, Volker , SCHRAEML, Michael , SOUKUPOVA, Monika , TACKE, Michael
IPC分类号： G01N33/50 , G01N33/531
CPC分类号： C07K16/468 , G01N33/531
摘要： A bi-valent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bi-valent binding agent, and for use of the disclosed bi-valent binding agent in histological staining procedures.
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4.发明公开COMBINATION THERAPY OF AN AFUCOSYLATED CD20 ANTIBODY WITH A CD79b ANTIBODY-DRUG CONJUGATE 有权联合治疗从AFUCOSYLIERTEN CD20抗体和CD79b抗体药物偶联物
公开(公告)号：EP2992016A2
公开(公告)日：2016-03-09
申请号：EP14724662.3
申请日：2014-04-30
CPC分类号： A61K39/39558 , A61K31/40 , A61K31/5365 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K2039/507 , C07K16/2803 , C07K16/2887 , C07K2317/41 , C07K2317/76
摘要： The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with a CD79b antibody-drug conjugate for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody and a CD79b antibody-drug conjugate.
摘要翻译： 本发明涉及具有一个CD79b抗体 - 药物偶联物用于治疗癌症的非岩藻糖化抗CD20抗体的组合疗法，特别爱CD20中的非岩藻糖化的人源化B-LY1抗体表达与癌症的组合疗法和CD79b抗体 - 药物共轭。
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公开(公告)号：EP2855531A1
公开(公告)日：2015-04-08
申请号：EP13724269.9
申请日：2013-05-22
发明人： CASTOLDI, Raffaella , HAAS, Alexander , KLEIN, Christian , SCHAEFER, Wolfgang , SUSTMANN, Claudio
IPC分类号： C07K16/46 , C07K16/32 , C07K16/28 , C07K16/22 , A61K39/395
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/2863 , C07K16/468 , C07K2317/31 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/66 , C07K2317/92 , C07K2319/70
摘要： The present invention relates to bivalent, multispecific antibodies, especially bivalent, trispecific antibodies which bind to human HER1, human HER2, and human HER3, their manufacture and use.
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公开(公告)号：EP2443154A1
公开(公告)日：2012-04-25
申请号：EP10725615.8
申请日：2010-06-14
发明人： IMHOF-JUNG, Sabine , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael
CPC分类号： C07K16/22 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present disclosure relates to bispecific antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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7.发明公开BISPECIFIC HER2 ANTIBODIES AND METHODS OF USE 有权BISPEZIFISCHE HER2-ANTIKÖRPERUND VERFAHREN ZUR VERWENDUNG
公开(公告)号：EP3083696A1
公开(公告)日：2016-10-26
申请号：EP14821603.9
申请日：2014-12-18
发明人： CROASDALE, Rebecca , DUERNER, Lydia Jasmin , GEORGES, Guy , HOFER, Thomas , HOSSE, Ralf , KLEIN, Christian , MOESSNER, Ekkehard , MOSER, Samuel , SCHAEFER, Wolfgang , SCHANZER, Juergen Michael , SCHEUER, Werner , SUSTMANN, Claudio , UMANA, Pablo
IPC分类号： C07K16/32
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific HER2 antibodies, novel HER2 antibody variants, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及双特异性HER2抗体，新型HER2抗体变体，其制备方法，含有所述抗体的药物组合物及其用途。
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8.发明公开COMBINATION THERAPY OF A TYPE II ANTI-CD20 ANTIBODY WITH A SELECTIVE BCL-2 INHIBITOR 审中-公开从II型CD20抗体和选择性BCL-2 MHEMMER联合治疗
公开(公告)号：EP2892557A1
公开(公告)日：2015-07-15
申请号：EP13767170.7
申请日：2013-09-06
IPC分类号： A61K39/395 , A61K31/496 , A61P35/02
CPC分类号： A61K31/496 , A61K2300/00
摘要： The present invention is directed to a combination therapy involving a type II anti-CD20 antibody and a selective Bcl-2 inhibitor for the treatment of a patient suffering from cancer, particularly, a CD20-expressing cancer.
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公开(公告)号：EP2443153B1
公开(公告)日：2013-11-06
申请号：EP10724717.3
申请日：2010-06-14
发明人： IMHOF-JUNG, Sabine , KLEIN, Christian , REGULA, Jörg Thomas , SCHAEFER, Wolfgang , SCHANZER, Jürgen Michael
CPC分类号： C07K16/468 , C07K16/22 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2319/00
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公开(公告)号：EP2552960A1
公开(公告)日：2013-02-06
申请号：EP11711071.8
申请日：2011-03-24
发明人： BAEHNER, Monika , IMHOF-JUNG, Sabine , KAVLIE, Anita , KETTENBERGER, Hubert , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael , SCHEUER, Werner , STUBENRAUCH, Kay-Gunnar , THOMAS, Markus
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/3015 , C07K16/3046 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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