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1.发明授权Antibodies binding to human CSF1R extracellular domain 4 and their use 有权结合人4 CSF1R的胞外结构域抗体，以及它们的使用
公开(公告)号：EP2510010B1
公开(公告)日：2015-11-25
申请号：EP10794936.4
申请日：2010-12-07
发明人： DIMOUDIS, Nikolaos , FERTIG, Georg , FIDLER, Alexander , KALUZA, Klaus , THOMAS, Marlene , RIES, Carola , SEEBER, Stefan , LANZENDOERFER, Martin
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及抗人CSF-1R（抗CSF-1R抗体）它们的生产方法，含有所述抗体的药物组合物的抗体及其用途。
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公开(公告)号：EP2678358A1
公开(公告)日：2014-01-01
申请号：EP12704831.2
申请日：2012-02-22
发明人： FERTIG, Georg , GEORGES, Guy , KALUZA, Klaus , LIFKE, Valeria , MOELLEKEN, Joerg , OFFNER, Sonja , PASHINE, Achal , SEEBER, Stefan , FISCHER, Jens
IPC分类号： C07K16/28 , A61K39/395 , A61P37/06 , A61P11/06 , A61P19/02
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/76 , C07K2317/92
摘要： An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO: l, a CDR2 region of SEQ ID NO:2 and a CDRl region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDRl region of SEQ ID NO:6 or a a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.
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3.发明公开ANTIBODIES AGAINST HUMAN CSF-1R AND USES THEREOF 有权ANTIKÖRPERGEGEN MENSCHLICHEN CSF-1R UND DEREN VERWENDUNGEN
公开(公告)号：EP2791174A1
公开(公告)日：2014-10-22
申请号：EP12798775.8
申请日：2012-12-12
发明人： FERTIG, Georg , FIDLER, Alexander , KALUZA, Klaus , RIES, Carola , SEEBER, Stefan , THOMAS, Marlene
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/33 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CSF-1R（CSF-1R抗体）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：EP2542588A1
公开(公告)日：2013-01-09
申请号：EP11723276.9
申请日：2011-03-03
发明人： FERTIG, Georg , FIDLER, Alexander , KALUZA, Klaus , THOMAS, Marlene , RIES, Carola , SEEBER, Stefan
IPC分类号： C07K16/28 , A61P35/00 , A61P35/04 , A61K39/395 , C12N15/13
CPC分类号： C07K16/2866 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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5.发明公开ANTIBODIES BINDING PREFERENTIALLY HUMAN CSF1R EXTRACELLULAR DOMAIN 4 AND THEIR USE 有权结合人4 CSF1R的胞外结构域抗体，以及它们的使用
公开(公告)号：EP2510010A1
公开(公告)日：2012-10-17
申请号：EP10794936.4
申请日：2010-12-07
发明人： DIMOUDIS, Nikolaos , FERTIG, Georg , FIDLER, Alexander , KALUZA, Klaus , PICKL, Marlene , RIES, Carola , SEEBER, Stefan
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：EP1664121B1
公开(公告)日：2009-07-08
申请号：EP04764984.3
申请日：2004-09-09
发明人： BARTKE, Ilse , CARR, Francis , CHIZZONITE, Anthony , EUGUI, Elsie , FERTIG, Georg , HAMILTON, Anita , LANZENDOERFER, Martin , RUEGER, Petra , SCHUMACHER, Ralf , TRUITT, Theresa
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： An antibody binding to human IL-1R and inhibiting the binding of human IL-1 to IL-1R, characterized in that said antibody is obtainable from hybridoma cell line MAK 2D8 (DSM ACC 2601) or is a chimeric, humanized or T cell epitope depleted antibody variant or a fragment of said antibody showing an IC50 value of 35 pM or lower for the inhibition of IL-1 mediated secretion of Il-8 and IL-6 in human fibroblast cells like MRC5 (ATCC CCL 171) has advantageous properties for the treatment of inflammatory diseases.
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7.发明公开
公开(公告)号：EP2470206A1
公开(公告)日：2012-07-04
申请号：EP10749787.7
申请日：2010-08-26
发明人： BOSSENMAIER, Birgit , FERTIG, Georg , KRELL, Hans-Willi , LAMMERS, Reiner , LIFKE, Alexander , NIEDERFELLNER, Gerhard
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present disclosure relates to antibodies against human CDCPl binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
摘要翻译： 本发明涉及抗CDCP1与CUB4（沉积号DSM ACC2551）相同表位的抗体用于治疗癌症的抗体。
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8.发明公开
公开(公告)号：EP1778683A1
公开(公告)日：2007-05-02
申请号：EP05748028.7
申请日：2005-06-13
发明人： FERTIG, Georg , HERTING, Frank , KOERNER, Matthias , KUBBIES, Manfred , LIMBERG, Anja , REIFF, Ulrike , TIBES, Ulrich
IPC分类号： C07D413/12 , C07D333/44 , C07D333/58 , C07D409/12 , C07D413/14 , C07D409/14 , A61K31/422 , A61K31/381 , A61K31/4155 , A61K31/404 , A61K31/4436 , A61K31/4178 , A61P35/00
CPC分类号： C07D409/12 , C07D333/44 , C07D333/58 , C07D409/14 , C07D413/12 , C07D413/14
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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公开(公告)号：EP2678358B1
公开(公告)日：2015-07-22
申请号：EP12704831.2
申请日：2012-02-22
发明人： FERTIG, Georg , GEORGES, Guy , KALUZA, Klaus , LIFKE, Valeria , MOELLEKEN, Joerg , OFFNER, Sonja , PASHINE, Achal , SEEBER, Stefan , FISCHER, Jens
IPC分类号： C07K16/28 , A61K39/395 , A61P37/06 , A61P11/06 , A61P19/02
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/76 , C07K2317/92
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10.发明公开ANTIBODIES AGAINST HUMAN CSF-1R AND USES THEREOF 审中-公开ANTIKÖRPERGEGEN MENSCHLICHEN CSF-1R UND IHRE VERWENDUNG
公开(公告)号：EP2542587A1
公开(公告)日：2013-01-09
申请号：EP11706266.1
申请日：2011-03-03
发明人： FERTIG, Georg , FIDLER, Alexander , KALUZA, Klaus , THOMAS, Marlene , RIES, Carola , SEEBER, Stefan
CPC分类号： C07K16/2866 , A61K47/6849 , C07K16/28 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CSF-1R（CSF-1R抗体）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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