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公开(公告)号：EP1924264B1
公开(公告)日：2013-09-18
申请号：EP06778331.6
申请日：2006-08-23
发明人： BROKA, Chris Allen , CARTER, David Scott , DILLON, Michael Patrick , FORD, Anthony P.D.W. , HAWLEY, Ronald Charles , JAHANGIR, Alam , MOORE, Amy Geraldine , PARISH, Daniel Warren
IPC分类号： A61K31/505 , A61K31/506 , A61K31/513 , A61P11/00 , A61P11/06 , A61P1/00
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
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公开(公告)号：EP1924264A1
公开(公告)日：2008-05-28
申请号：EP06778331.6
申请日：2006-08-23
发明人： BROKA, Chris Allen , CARTER, David Scott , DILLON, Michael Patrick , FORD, Anthony P.D.W. , HAWLEY, Ronald Charles , JAHANGIR, Alam , MOORE, Amy Geraldine , PARISH, Daniel Warren
IPC分类号： A61K31/505 , A61K31/506 , A61P11/00 , A61P11/06 , A61P1/00
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
摘要： Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
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公开(公告)号：EP1924564B1
公开(公告)日：2016-11-09
申请号：EP06778312.6
申请日：2006-08-21
IPC分类号： C07D239/48 , C07D403/12 , C07D407/12 , C07D413/12 , A61K31/506 , A61P11/00 , A61P13/00
CPC分类号： C07D239/48
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公开(公告)号：EP1924264B9
公开(公告)日：2014-02-19
申请号：EP06778331.6
申请日：2006-08-23
发明人： BROKA, Chris Allen , CARTER, David Scott , DILLON, Michael Patrick , FORD, Anthony P.D.W. , HAWLEY, Ronald Charles , JAHANGIR, Alam , MOORE, Amy Geraldine , PARISH, Daniel Warren
IPC分类号： A61K31/505 , A61K31/506 , A61K31/513 , A61P11/00 , A61P11/06 , A61P1/00
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
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公开(公告)号：EP1924565A1
公开(公告)日：2008-05-28
申请号：EP06778313.4
申请日：2006-08-21
IPC分类号： C07D239/48 , C07D401/12 , A61K31/506 , A61P11/00 , A61P13/00
CPC分类号： C07D401/12 , C07D239/48 , C07D471/04
摘要： Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein A, D, E, G, J, X, Y, Z R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
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公开(公告)号：EP1924565B1
公开(公告)日：2016-09-14
申请号：EP06778313.4
申请日：2006-08-21
IPC分类号： C07D239/48 , C07D401/12 , A61K31/506 , A61P11/00 , A61P13/00
CPC分类号： C07D401/12 , C07D239/48 , C07D471/04
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公开(公告)号：EP1924566A1
公开(公告)日：2008-05-28
申请号：EP06778314.2
申请日：2006-08-21
IPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K31/506 , A61P11/00 , A61P13/00
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the compounds being of formula (I) wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 化合物和用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和式（I）化合物，其中D，X，R1，R2，R3，R4，R5，R6，R7和R8为 在此定义。
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公开(公告)号：EP1924564A1
公开(公告)日：2008-05-28
申请号：EP06778312.6
申请日：2006-08-21
IPC分类号： C07D239/48 , C07D403/12 , C07D407/12 , C07D413/12 , A61K31/506 , A61P11/00 , A61P13/00
CPC分类号： C07D239/48
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I), wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
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公开(公告)号：EP1689740A1
公开(公告)日：2006-08-16
申请号：EP04819594.5
申请日：2004-11-16
发明人： JAHANGIR, Alam , O'YANG, Counde
IPC分类号： C07D403/04 , A61K31/506 , A61P25/00
CPC分类号： C07D403/04
摘要： Compounds of the formula (I), and pharmaceutically acceptable salts thereof, wherein X, Y, Z and R1 are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I for preparing medicaments.
摘要翻译： 式（I）化合物及其药学上可接受的盐，其中X，Y，Z和R 1如本文所定义。 本发明还提供了制备用于制备药物的组合物，组合物以及使用式I化合物的方法。
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10.发明公开THIOPHENYLAMINOIMIDAZOLINES AS PROSTAGLANDIN I2 ANTAGONISTS 审中-公开THIOPHENYLAMINOIMIDAZOLINE前列腺素2拮抗剂
公开(公告)号：EP1656350A2
公开(公告)日：2006-05-17
申请号：EP04740722.6
申请日：2004-07-07
IPC分类号： C07D211/72 , C07D405/12 , C07D401/12 , C07D295/08 , C07D243/04 , C07D239/14 , C07D207/22 , A61K31/4168
CPC分类号： C07D295/096 , C07D211/72 , C07D233/50 , C07D239/14 , C07D243/08 , C07D401/12 , C07D405/12 , C07D487/04
摘要： Methods for treatment of IP antagonist mediated diseases or conditions by administration to a subject in need thereof a compound of formula (I) wherein R1, R 2 , A and X are as defined herein. Also disclosed are compounds and related compositions.
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