公开(公告)号：EP2074096A1

公开(公告)日：2009-07-01

申请号：EP07820501.0

申请日：2007-09-24

申请人： F.HOFFMANN-LA ROCHE AG

发明人： ANDJELKOVIC, Mirjana ,  BÉNARDEAU, Agnès ,  CHAPUT, Evelyne ,  HEBEISEN, Paul ,  NETTEKOVEN, Matthias ,  OBST SANDER, Ulrike ,  PANOUSIS, Constantinos G. ,  ROEVER, Stephan

IPC分类号： C07D213/63 ,  C07D213/74 ,  C07D241/24 ,  A61K31/465 ,  A61K31/4965 ,  A61P9/00

CPC分类号： C07D213/82 ,  C07D213/74 ,  C07D241/24

摘要： The present invention relates to the use of compounds of the formula wherein A, G, R1 to R8 and R17 are as defined in the description, for the preparation of medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as peripheral vascular disease, dyslipidemia, hyperbetalipoproteinemia, hypoalphalipoproteinemia, hypercholesterolemia, hypertriglyceridemia, familial hypercholesterolemia, cardiovascular disorders, angina, ischemia, cardiac ischemia, stroke, myocardial infarction, reperfusion injury, angioplastic restenosis, hypertension, and vascular complications of diabetes, obesity or endotoxemia.

公开(公告)号：EP2074096B1

公开(公告)日：2012-06-27

申请号：EP07820501.0

申请日：2007-09-24

申请人： F.Hoffmann-La Roche AG

发明人： ANDJELKOVIC, Mirjana ,  BÉNARDEAU, Agnès ,  CHAPUT, Evelyne ,  HEBEISEN, Paul ,  NETTEKOVEN, Matthias ,  OBST SANDER, Ulrike ,  PANOUSIS, Constantinos G. ,  ROEVER, Stephan

IPC分类号： C07D213/63 ,  C07D213/74 ,  C07D241/24 ,  A61K31/465 ,  A61K31/4965 ,  A61P9/00

CPC分类号： C07D213/82 ,  C07D213/74 ,  C07D241/24

摘要： The present invention relates to the use of compounds of the formula wherein A, G, R1 to R8 and R17 are as defined in the description, for the preparation of medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as peripheral vascular disease, dyslipidemia, hyperbetalipoproteinemia, hypoalphalipoproteinemia, hypercholesterolemia, hypertriglyceridemia, familial hypercholesterolemia, cardiovascular disorders, angina, ischemia, cardiac ischemia, stroke, myocardial infarction, reperfusion injury, angioplastic restenosis, hypertension, and vascular complications of diabetes, obesity or endotoxemia.

摘要翻译： 本发明涉及下式化合物在制备用于治疗和/或预防可用HDL-C治疗的疾病的药物中的用途，其中A，G，R 1至R 8和R 17如说明书中所定义， 例如外周血管疾病，血脂异常，高β脂蛋白血症，低α脂蛋白血症，高胆固醇血症，高甘油三酯血症，家族性高胆固醇血症，心血管病症，心绞痛，局部缺血，心脏缺血，中风，心肌梗塞，再灌注损伤，血管再狭窄，高血压和血管并发症 糖尿病，肥胖或内毒素血症。

公开(公告)号：EP1931651A1

公开(公告)日：2008-06-18

申请号：EP06793734.2

申请日：2006-09-22

申请人： F.HOFFMANN-LA ROCHE AG

发明人： DEHMLOW, Henrietta ,  GRETHER, Uwe ,  KRATOCHWIL, Nicole A. ,  NARQUIZIAN, Robert ,  PANOUSIS, Constantinos G.

IPC分类号： C07D333/38 ,  A61K31/38 ,  A61P3/00 ,  C07D409/12

CPC分类号： C07D409/12 ,  C07D333/38

摘要： The invention is concerned with novel substituted thiophene derivatives of formula (I), wherein R1 to R8, X, m and n are as defined in the description and in the claims, as well as 5 physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.