-
公开(公告)号：EP2773619B1
公开(公告)日：2016-11-16
申请号：EP12780486.2
申请日：2012-10-29
发明人： CECCARELLI, Simona M. , CONTE, Aurelia , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RUDOLPH, Markus
IPC分类号： C07D215/56 , C07D401/04 , C07D401/14 , C07D413/04 , A61K31/47 , A61K31/4709 , A61P3/10 , A61P35/00
CPC分类号： C07D491/048 , C07D215/00 , C07D215/02 , C07D215/227 , C07D215/54 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.
-
公开(公告)号：EP2861574B1
公开(公告)日：2016-04-20
申请号：EP13728748.8
申请日：2013-06-14
发明人： BUETTELMANN, Bernd , CECCARELLI, Simona M. , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D495/04 , C07D495/10 , A61K31/381 , A61P3/10 , A61P35/00
CPC分类号： C07D417/04 , C07D333/50 , C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D495/04 , C07D495/10
-
公开(公告)号：EP2888245A1
公开(公告)日：2015-07-01
申请号：EP13750576.4
申请日：2013-08-19
发明人： BUETTELMANN, Bernd , CONTE, Aurelia , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D401/14 , C07D215/48 , C07D401/04 , C07D401/06 , C07D471/04 , A61K31/4353 , A61K31/47 , A61P3/10
CPC分类号： C07D491/052 , C07D215/54 , C07D221/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D495/04
摘要： The invention provides novel compounds having the general formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , R
9 , R
10 , R
11 , A
1 , A
2 , A
3 , m, n and p are as described herein, compositions including the compounds and methods of using the compounds.-
4.发明公开1-CYCLOALKYL- OR 1-HETEROCYCLYL-HYDROXYIMINO-3-PHENYL-PROPANES 审中-公开1-环烷基-2-甲基-1-环己基 - 羟基亚氨基-3-苯基丙酸
公开(公告)号：EP2771313A1
公开(公告)日：2014-09-03
申请号：EP12775028.9
申请日：2012-10-23
发明人： DEHMLOW, Henrietta , MARTIN, Rainer E. , MATTEI, Patrizio , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07C251/42 , C07C317/32 , C07D211/40 , C07D309/06 , C07D335/02 , A61K31/15 , A61K31/35 , A61K31/382 , A61K31/445 , A61K31/45 , A61P3/10
CPC分类号： C07D401/10 , C07C251/42 , C07C317/32 , C07C2601/04 , C07C2601/14 , C07D211/28 , C07D211/76 , C07D309/04 , C07D335/02
摘要： This invention relates to novel 1-cycloalkyl- or l-heterocyclyl-hydroxyimino-3-phen propanes of the formula wherein R
1 to R
7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may therefore be useful as medicaments for the treatment of diseases such as type II diabetes.摘要翻译： 本发明涉及下式的新的1-环烷基 - 或1-杂环基 - 肟基-3-苯基 - 丙烷，其中R 1至R 7如说明书和权利要求书中所定义，以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂，因此可用作治疗诸如II型糖尿病的疾病的药物。
-
5.发明公开3-PYRIDINECARBOXAMIDE AND 2-PYRAZINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS 有权-3-吡啶甲酰胺和2- PYRAZINCARBOXAMIDDERIVATE ALS HDLCHOLERSTERINERHÖHENDEMEDIUM
公开(公告)号：EP2074096A1
公开(公告)日：2009-07-01
申请号：EP07820501.0
申请日：2007-09-24
发明人： ANDJELKOVIC, Mirjana , BÉNARDEAU, Agnès , CHAPUT, Evelyne , HEBEISEN, Paul , NETTEKOVEN, Matthias , OBST SANDER, Ulrike , PANOUSIS, Constantinos G. , ROEVER, Stephan
IPC分类号： C07D213/63 , C07D213/74 , C07D241/24 , A61K31/465 , A61K31/4965 , A61P9/00
CPC分类号： C07D213/82 , C07D213/74 , C07D241/24
摘要： The present invention relates to the use of compounds of the formula wherein A, G, R1 to R8 and R17 are as defined in the description, for the preparation of medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as peripheral vascular disease, dyslipidemia, hyperbetalipoproteinemia, hypoalphalipoproteinemia, hypercholesterolemia, hypertriglyceridemia, familial hypercholesterolemia, cardiovascular disorders, angina, ischemia, cardiac ischemia, stroke, myocardial infarction, reperfusion injury, angioplastic restenosis, hypertension, and vascular complications of diabetes, obesity or endotoxemia.
-
6.发明授权1-PYRIDAZINYL-HYDROXYIMINO- 3- PHENYL- PROPANES AS GPBAR1 AGONISTS 有权1-吡啶基 - 羟基亚氨基-3-苯基 - 丙酸甲酯GPBAR1-AGONISTEN
公开(公告)号：EP2780330B1
公开(公告)日：2016-01-06
申请号：EP12784005.6
申请日：2012-11-12
发明人： DEHMLOW, Henrietta , MARTIN, Rainer E. , MATTEI, Patrizio , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D237/08 , A61K31/50 , A61P3/10
CPC分类号： C07D237/08 , C07D237/14 , C07D401/10
-
公开(公告)号：EP2948446A1
公开(公告)日：2015-12-02
申请号：EP14700493.1
申请日：2014-01-15
发明人： WOLTERING, Thomas , GUBA, Wolfgang , HILPERT, Hans , KUGLSTATTER, Andreas , LIMBERG, Anja , OBST SANDER, Ulrike , PINARD, Emmanuel , WOSTL, Wolfgang
IPC分类号： C07D413/14 , C07D413/10 , C07D413/12 , A61K31/5355 , A61P25/28
CPC分类号： C07D413/14 , C07D413/04 , C07D413/10 , C07D413/12
摘要： The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
摘要翻译： 本发明提供具有BACE1抑制活性的式I化合物，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默氏病。
-
公开(公告)号：EP2861574A1
公开(公告)日：2015-04-22
申请号：EP13728748.8
申请日：2013-06-14
发明人： BUETTELMANN, Bernd , CECCARELLI, Simona M. , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D495/04 , C07D495/10 , A61K31/381 , A61P3/10 , A61P35/00
CPC分类号： C07D417/04 , C07D333/50 , C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D495/04 , C07D495/10
摘要： The invention provides novel compounds having the general formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , A, E and n are as described herein, compositions including the compounds and use thereof as fatty-acid binding protein (FABP) 4/5 inhibitors in the treatment of e.g. type 2 diabetes, atherosclerosis or cancer.摘要翻译： 本发明提供了具有通式（I）的新化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，A，E和n如本文所述，包括所述化合物和用途的组合物 作为脂肪酸结合蛋白（FABP）4/5抑制剂在治疗例如， 2型糖尿病，动脉粥样硬化或癌症。
-
公开(公告)号：EP2593426B1
公开(公告)日：2014-08-20
申请号：EP11730660.5
申请日：2011-07-08
发明人： BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn, David , KIM, Kyungjin , MARTIN, Rainer, E. , MATTEI, Patrizio , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie, Lynn , RICHTER, Hans , ULLMER, Christoph
IPC分类号： C07C251/48 , C07D213/53 , C07D213/55 , C07D213/64 , C07D213/89 , C07D215/12 , C07D239/26 , C07D241/12
CPC分类号： C07C251/48 , C07C2601/02 , C07C2601/14 , C07D213/53 , C07D213/55 , C07D213/64 , C07D213/89 , C07D215/12 , C07D239/26 , C07D241/12 , C07D401/10 , C07D413/10 , C07D417/10
-
10.发明公开4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS 有权4-苯氧基 - 烟酰胺或4-苯氧基 - 嘧啶-4-甲酰胺
公开(公告)号：EP2526096A1
公开(公告)日：2012-11-28
申请号：EP11700348.3
申请日：2011-01-18
发明人： BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn, David , KIM, Kyungjin , MARTIN, Rainer, E. , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie, Lynn , RICHTER, Hans , ULLMER, Christoph
IPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D417/12 , A61K31/44 , A61K31/4427 , A61K31/506 , A61P3/00
CPC分类号： C07D417/14 , C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D417/12
摘要： This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula (I), wherein A
1 , A
2 , B
1 , B
2 and R
1 to R
11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
-
-
-
-
-
-
-
-
-
搜索结果
27 条记录 (耗时 0.024 秒)
