公开(公告)号：EP2694480B1

公开(公告)日：2015-03-04

申请号：EP12711669.7

申请日：2012-04-04

申请人： F.Hoffmann-La Roche AG

发明人： CHEUNG, Adrian Wai-Hing ,  GUERTIN, Kevin Richard ,  HAYNES, Nancy-Ellen ,  MERTZ, Eric ,  QI, Lida ,  QIAN, Yimin ,  SCOTT, Nathan Robert

IPC分类号： C07D215/48 ,  C07D401/04 ,  C07D413/04 ,  C07D471/04

CPC分类号： C07D215/233 ,  C07D215/48 ,  C07D401/04 ,  C07D401/06 ,  C07D413/04 ,  C07D471/04

公开(公告)号：EP2027132A1

公开(公告)日：2009-02-25

申请号：EP07728869.4

申请日：2007-05-08

申请人： F.HOFFMANN-LA ROCHE AG

发明人： BRINKMAN, John A. ,  CHEUNG, Adrian Wai-Hing ,  FIROOZNIA, Fariborz ,  GUERTIN, Kevin Richard ,  MARCOPULOS, Nicholas ,  QI, Lida ,  RACHA, Jagdish Kumar ,  SARABU, Ramakanth ,  TAN, Jenny ,  TILLEY, Jefferson Wright

IPC分类号： C07D513/04 ,  C07D521/00 ,  A61K31/519 ,  A61K31/437 ,  A61P3/10

CPC分类号： C07D513/04 ,  C07D521/00

摘要： There are presented compounds of the formula (I) wherein R1, R2, R3 and R4 are as defined in the description and claims, or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.

公开(公告)号：EP2731932A1

公开(公告)日：2014-05-21

申请号：EP12734923.1

申请日：2012-07-09

申请人： F.Hoffmann-La Roche AG

发明人： BILOTTA, Joseph Anthony ,  CHEUNG, Adrian Wai-Hing ,  FIROOZNIA, Fariborz ,  GUERTIN, Kevin Richard ,  HAYDEN, Stuart ,  HAYNES, Nancy-Ellen ,  LUKACS-LESBURG, Christine M. ,  MARCOPULOS, Nicholas ,  MERTZ, Eric ,  QI, Lida ,  QIAN, Yimin ,  SO, Sung-Sau ,  TAN, Jenny ,  THAKKAR, Kshitij Chhabilbhai

IPC分类号： C07D215/48 ,  C07D401/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D215/233 ,  A61K31/4709 ,  A61P3/10 ,  A61P19/00 ,  A61P35/00 ,  A61P25/00

CPC分类号： C07D215/48 ,  C07D215/233 ,  C07D401/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula (I): wherein the variables are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.

公开(公告)号：EP2731932B1

公开(公告)日：2015-12-30

申请号：EP12734923.1

申请日：2012-07-09

申请人： F.Hoffmann-La Roche AG

发明人： BILOTTA, Joseph Anthony ,  CHEUNG, Adrian Wai-Hing ,  FIROOZNIA, Fariborz ,  GUERTIN, Kevin Richard ,  HAYDEN, Stuart ,  HAYNES, Nancy-Ellen ,  LUKACS-LESBURG, Christine M. ,  MARCOPULOS, Nicholas ,  MERTZ, Eric ,  QI, Lida ,  QIAN, Yimin ,  SO, Sung-Sau ,  TAN, Jenny ,  THAKKAR, Kshitij Chhabilbhai

IPC分类号： C07D215/48 ,  C07D401/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D215/233 ,  A61K31/4709 ,  A61P3/10 ,  A61P19/00 ,  A61P35/00 ,  A61P25/00

CPC分类号： C07D215/48 ,  C07D215/233 ,  C07D401/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

公开(公告)号：EP2694480A1

公开(公告)日：2014-02-12

申请号：EP12711669.7

申请日：2012-04-04

申请人： F.Hoffmann-La Roche AG

发明人： CHEUNG, Adrian Wai-Hing ,  GUERTIN, Kevin Richard ,  HAYNES, Nancy-Ellen ,  MERTZ, Eric ,  QI, Lida ,  QIAN, Yimin ,  SCOTT, Nathan Robert

IPC分类号： C07D215/48 ,  C07D401/04 ,  C07D413/04 ,  C07D471/04

CPC分类号： C07D215/233 ,  C07D215/48 ,  C07D401/04 ,  C07D401/06 ,  C07D413/04 ,  C07D471/04

摘要： The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula (I): wherein the variables are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.

公开(公告)号：EP2027132B1

公开(公告)日：2010-09-15

申请号：EP07728869.4

申请日：2007-05-08

申请人： F.HOFFMANN-LA ROCHE AG

发明人： BRINKMAN, John A. ,  CHEUNG, Adrian Wai-Hing ,  FIROOZNIA, Fariborz ,  GUERTIN, Kevin Richard ,  MARCOPULOS, Nicholas ,  QI, Lida ,  RACHA, Jagdish Kumar ,  SARABU, Ramakanth ,  TAN, Jenny ,  TILLEY, Jefferson Wright

IPC分类号： C07D513/04 ,  C07D521/00 ,  A61K31/519 ,  A61K31/437 ,  A61P3/10

CPC分类号： C07D513/04 ,  C07D521/00

摘要： There are presented compounds of the formula (I) wherein R1, R2, R3 and R4 are as defined in the description and claims, or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.

摘要翻译： 提供了式（I）化合物，其中R 1，R 2，R 3和R 4如说明书和权利要求书中所定义，或其药学上可接受的盐，它们是活性的腺苷A 2B受体拮抗剂并可用于治疗糖尿病，糖尿病 视网膜病，哮喘和腹泻。

公开(公告)号：EP1791822A1

公开(公告)日：2007-06-06

申请号：EP05774995.4

申请日：2005-07-28

申请人： F.HOFFMANN-LA ROCHE AG

发明人： CAI, Jianping ,  FIROOZNIA, Fariborz ,  GUERTIN, Kevin, Richard ,  QI, Lida

IPC分类号： C07D277/60 ,  C07D277/84

CPC分类号： C07D277/60 ,  C07D277/84 ,  C07D417/12 ,  C07D513/04

摘要： The invention is concerned with novel substituted N-acyl-2-aminothiazoles of the formula (I) wherein R, Ri and X are as defined in the specification and claims, as well as pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.