公开(公告)号：EP2547338A2

公开(公告)日：2013-01-23

申请号：EP11708831.0

申请日：2011-03-15

申请人： F.Hoffmann-La Roche AG

发明人： LAI, Yingjie ,  LIANG, Jun ,  MAGNUSON, Steven R. ,  TSUI, Vickie H. ,  ZHANG, Birong ,  ROBARGE, Kirk

IPC分类号： A61K31/437 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/444 ,  A61K31/501 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/541 ,  C07D471/04 ,  C07D473/34 ,  C07D491/107 ,  A61P1/00 ,  A61P17/06 ,  A61P29/00

CPC分类号： C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D519/00

摘要： The invention provides compounds of Formulas Ia-Ib, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R
1 , R
2 , R
4 , R
5 and R
16 are defined herein, a pharmaceutical composition that includes a compound of Formulas Ia-Ib and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of using the compound or composition in therapy.